Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country

TY - JOUR

T1 - Regional gastrointestinal contractility parameters using the wireless motility capsule

T2 - inter-observer reproducibility and influence of age, gender and study country

AU - Farmer, A D

AU - Wegeberg, A-M L

AU - Brock, B

AU - Hobson, A R

AU - Mohammed, S D

AU - Scott, S M

AU - Bruckner-Holt, C E

AU - Semler, J R

AU - Hasler, W L

AU - Hellström, P M

AU - Drewes, A M

AU - Brock, C

N1 - © 2017 John Wiley & Sons Ltd.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres. Methods: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators. Results: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r =.24, P =.01; r =.22, P =.02; and r =.2, P =.04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P =.04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log e motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P <.0003) but not with transit times. Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.

AB - Background: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres. Methods: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators. Results: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r =.24, P =.01; r =.22, P =.02; and r =.2, P =.04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P =.04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log e motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P <.0003) but not with transit times. Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.

KW - Journal Article

U2 - 10.1111/apt.14438

DO - 10.1111/apt.14438

M3 - Journal article

C2 - 29210098

SN - 0269-2813

VL - 47

SP - 391

EP - 400

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

IS - 3

ER -