Regional activation of the human medial temporal lobe during intentional encoding of objects and positions: NeuroImage

T.Z. Ramsøy; Matthew George Liptrot; A. Skimminge; T.E. Lund; K. Sidaros; M.S. Christensen; W. Baaré; O.B. Paulson; T.L. Jernigan

doi:10.1016/j.neuroimage.2009.03.082

Regional activation of the human medial temporal lobe during intentional encoding of objects and positions: NeuroImage

T.Z. Ramsøy, Matthew George Liptrot, A. Skimminge, T.E. Lund, K. Sidaros, M.S. Christensen, W. Baaré, O.B. Paulson, T.L. Jernigan

12 Citations (Scopus)

Abstract

The medial temporal lobe (MTL) consists of several regions thought to be involved in learning and memory. However, the degree of functional specialization among these regions remains unclear. Previous studies have demonstrated effects of both content and processing stage, but findings have been inconsistent. In particular, studies have suggested that the perirhinal cortex is more involved in object processing than spatial processing, while other regions such as the parahippocampal cortex have been implicated in spatial processing. In this study, functional magnetic resonance imaging (fMRI) optimized for the MTL region was used to probe MTL activation during intentional encoding of object identities or positions. A region of interest analysis showed that object encoding evoked stronger activation than position encoding in bilateral perirhinal cortex, temporopolar cortex, parahippocampal cortex, hippocampus and amygdala. Results also indicate an unexpected significant correlation in activation level between anterior and posterior portions in both the left parahippocampal cortex and left hippocampus. Exploratory analysis did not show any regional content effects during preparation and rehearsal stages. These results provide additional evidence for functional specialization within the MTL, but were less clear regarding the specific nature of content specificity in these regions. © 2009 Elsevier Inc.

Original language	English
Journal	NeuroImage
Volume	47
Issue number	4
Pages (from-to)	1863-1872
Number of pages	10
ISSN	1053-8119
DOIs	https://doi.org/10.1016/j.neuroimage.2009.03.082
Publication status	Published - 2009

Keywords

Episodic memory
Functional MRI
Perirhinal cortex
Region of Interest analysis
Working memory
adult
amygdaloid nucleus
article
brain cortex
brain depth stimulation
brain function
evoked response
female
functional assessment
functional magnetic resonance imaging
hippocampus
human
human experiment
male
normal human
object relation
perceptive discrimination
priority journal
spatial discrimination
temporal cortex
temporal lobe
Adolescent
Adult
Brain Mapping
Evoked Potentials, Visual
Female
Form Perception
Humans
Magnetic Resonance Imaging
Male
Mental Recall
Temporal Lobe
Young Adult

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Cite this

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title = "Regional activation of the human medial temporal lobe during intentional encoding of objects and positions: NeuroImage",

abstract = "The medial temporal lobe (MTL) consists of several regions thought to be involved in learning and memory. However, the degree of functional specialization among these regions remains unclear. Previous studies have demonstrated effects of both content and processing stage, but findings have been inconsistent. In particular, studies have suggested that the perirhinal cortex is more involved in object processing than spatial processing, while other regions such as the parahippocampal cortex have been implicated in spatial processing. In this study, functional magnetic resonance imaging (fMRI) optimized for the MTL region was used to probe MTL activation during intentional encoding of object identities or positions. A region of interest analysis showed that object encoding evoked stronger activation than position encoding in bilateral perirhinal cortex, temporopolar cortex, parahippocampal cortex, hippocampus and amygdala. Results also indicate an unexpected significant correlation in activation level between anterior and posterior portions in both the left parahippocampal cortex and left hippocampus. Exploratory analysis did not show any regional content effects during preparation and rehearsal stages. These results provide additional evidence for functional specialization within the MTL, but were less clear regarding the specific nature of content specificity in these regions. {\textcopyright} 2009 Elsevier Inc.",

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author = "T.Z. Rams{\o}y and Liptrot, {Matthew George} and A. Skimminge and T.E. Lund and K. Sidaros and M.S. Christensen and W. Baar{\'e} and O.B. Paulson and T.L. Jernigan",

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doi = "10.1016/j.neuroimage.2009.03.082",

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T1 - Regional activation of the human medial temporal lobe during intentional encoding of objects and positions

T2 - NeuroImage

AU - Ramsøy, T.Z.

AU - Liptrot, Matthew George

AU - Skimminge, A.

AU - Lund, T.E.

AU - Sidaros, K.

AU - Christensen, M.S.

AU - Baaré, W.

AU - Paulson, O.B.

AU - Jernigan, T.L.

PY - 2009

Y1 - 2009

N2 - The medial temporal lobe (MTL) consists of several regions thought to be involved in learning and memory. However, the degree of functional specialization among these regions remains unclear. Previous studies have demonstrated effects of both content and processing stage, but findings have been inconsistent. In particular, studies have suggested that the perirhinal cortex is more involved in object processing than spatial processing, while other regions such as the parahippocampal cortex have been implicated in spatial processing. In this study, functional magnetic resonance imaging (fMRI) optimized for the MTL region was used to probe MTL activation during intentional encoding of object identities or positions. A region of interest analysis showed that object encoding evoked stronger activation than position encoding in bilateral perirhinal cortex, temporopolar cortex, parahippocampal cortex, hippocampus and amygdala. Results also indicate an unexpected significant correlation in activation level between anterior and posterior portions in both the left parahippocampal cortex and left hippocampus. Exploratory analysis did not show any regional content effects during preparation and rehearsal stages. These results provide additional evidence for functional specialization within the MTL, but were less clear regarding the specific nature of content specificity in these regions. © 2009 Elsevier Inc.

AB - The medial temporal lobe (MTL) consists of several regions thought to be involved in learning and memory. However, the degree of functional specialization among these regions remains unclear. Previous studies have demonstrated effects of both content and processing stage, but findings have been inconsistent. In particular, studies have suggested that the perirhinal cortex is more involved in object processing than spatial processing, while other regions such as the parahippocampal cortex have been implicated in spatial processing. In this study, functional magnetic resonance imaging (fMRI) optimized for the MTL region was used to probe MTL activation during intentional encoding of object identities or positions. A region of interest analysis showed that object encoding evoked stronger activation than position encoding in bilateral perirhinal cortex, temporopolar cortex, parahippocampal cortex, hippocampus and amygdala. Results also indicate an unexpected significant correlation in activation level between anterior and posterior portions in both the left parahippocampal cortex and left hippocampus. Exploratory analysis did not show any regional content effects during preparation and rehearsal stages. These results provide additional evidence for functional specialization within the MTL, but were less clear regarding the specific nature of content specificity in these regions. © 2009 Elsevier Inc.

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KW - brain depth stimulation

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DO - 10.1016/j.neuroimage.2009.03.082

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SP - 1863

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JO - NeuroImage

JF - NeuroImage

IS - 4

ER -

Regional activation of the human medial temporal lobe during intentional encoding of objects and positions: NeuroImage

Abstract

Keywords

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