Regional activation of the human medial temporal lobe during intentional encoding of objects and positions

TY - JOUR

T1 - Regional activation of the human medial temporal lobe during intentional encoding of objects and positions

AU - Ramsøy, Thomas Z.

AU - Liptrot, Matthew G.

AU - Skimminge, Arnold

AU - Lund, Torben E.

AU - Sidaros, Karam

AU - Christensen, Mark Schram

AU - Baaré, William

AU - Paulson, Olaf B.

AU - Jernigan, Terry L.

AU - Ramsøy, Thomas

AU - Liptrot, Matthew G

AU - Skimminge, Arnold

AU - Lund, Torben E

AU - Sidaros, Karam

AU - Christensen, Mark Schram

AU - Baaré, William

AU - Paulson, Olaf B

AU - Jernigan, Terry L

N1 - CURIS 2009 5200 043

PY - 2009

Y1 - 2009

N2 - The medial temporal lobe (MTL) consists of several regions thought to be involved in learning and memory. However, the degree of functional specialization among these regions remains unclear. Previous studies have demonstrated effects of both content and processing stage, but findings have been inconsistent. In particular, studies have suggested that the perirhinal cortex is more involved in object processing than spatial processing, while other regions such as the parahippocampal cortex have been implicated in spatial processing. In this study, functional magnetic resonance imaging (fMRI) optimized for the MTL region was used to probe MTL activation during intentional encoding of object identities or positions. A region of interest analysis showed that object encoding evoked stronger activation than position encoding in bilateral perirhinal cortex, temporopolar cortex, parahippocampal cortex, hippocampus and amygdala. Results also indicate an unexpected significant correlation in activation level between anterior and posterior portions in both the left parahippocampal cortex and left hippocampus. Exploratory analysis did not show any regional content effects during preparation and rehearsal stages. These results provide additional evidence for functional specialization within the MTL, but were less clear regarding the specific nature of content specificity in these regions.

AB - The medial temporal lobe (MTL) consists of several regions thought to be involved in learning and memory. However, the degree of functional specialization among these regions remains unclear. Previous studies have demonstrated effects of both content and processing stage, but findings have been inconsistent. In particular, studies have suggested that the perirhinal cortex is more involved in object processing than spatial processing, while other regions such as the parahippocampal cortex have been implicated in spatial processing. In this study, functional magnetic resonance imaging (fMRI) optimized for the MTL region was used to probe MTL activation during intentional encoding of object identities or positions. A region of interest analysis showed that object encoding evoked stronger activation than position encoding in bilateral perirhinal cortex, temporopolar cortex, parahippocampal cortex, hippocampus and amygdala. Results also indicate an unexpected significant correlation in activation level between anterior and posterior portions in both the left parahippocampal cortex and left hippocampus. Exploratory analysis did not show any regional content effects during preparation and rehearsal stages. These results provide additional evidence for functional specialization within the MTL, but were less clear regarding the specific nature of content specificity in these regions.

U2 - 10.1016/j.neuroimage.2009.03.082

DO - 10.1016/j.neuroimage.2009.03.082

M3 - Journal article

C2 - 19362156

SN - 1053-8119

VL - 47

SP - 1863

EP - 1872

JO - NeuroImage

JF - NeuroImage

IS - 4

ER -