Abstract
A study was performed to evaluate regeneration of defects in rat calvaria either unfilled or filled with a bioerodible polyorthoester only, demineralized bone only, or a composite of both. At 4 weeks, histological and radiographic studies showed that defects filled with a composite of bioerodible polyorthoester and demineralized bone or demineralized bone alone were bridged by bone. Unfilled defects or defects filled with polyorthoester only did not heal. The polyorthoester caused slight inflammation that subsided by 3 weeks, and only traces of the filler could be detected at 4 weeks. The polyorthoester provided local hemostasis when used either alone or in composites with demineralized bone. The composite implant was moldable, easily contoured, and technically easier to use than demineralized bone alone.
| Original language | English |
|---|---|
| Journal | Journal of Neurosurgery |
| Volume | 76 |
| Issue number | 2 |
| Pages (from-to) | 275-9 |
| Number of pages | 5 |
| ISSN | 0022-3085 |
| DOIs | |
| Publication status | Published - 1 Feb 1992 |
Keywords
- Animals
- Biocompatible Materials
- Bone Regeneration
- Bone Transplantation
- Inflammation
- Male
- Rats
- Rats, Inbred Strains
- Skull