Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13

D. Joller; Claus Bøttcher Jørgensen; H.U. Bertschinger; P. Python; I. Edfors; Susanna Cirera Salicio; A.L. Archibald; E. Bürgi; Peter Karlskov-Mortensen; L. Andersson; Merete Fredholm; P. Vögeli

doi:10.1111/j.1365-2052.2009.01881.x

Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13

D. Joller, Claus Bøttcher Jørgensen, H.U. Bertschinger, P. Python, I. Edfors, Susanna Cirera Salicio, A.L. Archibald, E. Bürgi, Peter Karlskov-Mortensen, L. Andersson, Merete Fredholm, P. Vögeli

24 Citations (Scopus)

Abstract

Diarrhoea in newborn and weaned pigs caused by enterotoxigenic Escherichia coli (ETEC) expressing F4 fimbriae leads to considerable losses in pig production. In this study, we refined the mapping of the receptor locus for ETEC F4ab/F4ac adhesion (F4bcR) by joint analysis of Nordic and Swiss data. A total of 236 pigs from a Nordic experimental herd, 331 pigs from a Swiss experimental herd and 143 pigs from the Swiss performing station were used for linkage analysis. Genotyping data of six known microsatellite markers, two newly developed markers (MUC4gt and HSA125gt) and an intronic SNP in MUC4 (MUC4-8227) were used to create the linkage map. The region for F4bcR was refined to the interval SW207-S0075 on pig chromosome 13. The most probable position of F4bcR was in the SW207-MUC4 region. The order of six markers was supported by physical mapping on the BAC fingerprint contig from the Wellcome Trust Sanger Institute. Thus, the region for F4bcR could be reduced from 26 to 14 Mb.

Original language	English
Journal	Animal Genetics
Volume	40
Issue number	5
Pages (from-to)	749-752
Number of pages	4
ISSN	0268-9146
DOIs	https://doi.org/10.1111/j.1365-2052.2009.01881.x
Publication status	Published - 2009

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Joller, D., Jørgensen, C. B., Bertschinger, H. U., Python, P., Edfors, I., Cirera Salicio, S., Archibald, A. L., Bürgi, E., Karlskov-Mortensen, P., Andersson, L., Fredholm, M., & Vögeli, P. (2009). Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13. Animal Genetics, 40(5), 749-752. https://doi.org/10.1111/j.1365-2052.2009.01881.x

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title = "Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13",

abstract = "Diarrhoea in newborn and weaned pigs caused by enterotoxigenic Escherichia coli (ETEC) expressing F4 fimbriae leads to considerable losses in pig production. In this study, we refined the mapping of the receptor locus for ETEC F4ab/F4ac adhesion (F4bcR) by joint analysis of Nordic and Swiss data. A total of 236 pigs from a Nordic experimental herd, 331 pigs from a Swiss experimental herd and 143 pigs from the Swiss performing station were used for linkage analysis. Genotyping data of six known microsatellite markers, two newly developed markers (MUC4gt and HSA125gt) and an intronic SNP in MUC4 (MUC4-8227) were used to create the linkage map. The region for F4bcR was refined to the interval SW207-S0075 on pig chromosome 13. The most probable position of F4bcR was in the SW207-MUC4 region. The order of six markers was supported by physical mapping on the BAC fingerprint contig from the Wellcome Trust Sanger Institute. Thus, the region for F4bcR could be reduced from 26 to 14 Mb.",

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T1 - Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13

AU - Joller, D.

AU - Jørgensen, Claus Bøttcher

AU - Bertschinger, H.U.

AU - Python, P.

AU - Edfors, I.

AU - Cirera Salicio, Susanna

AU - Archibald, A.L.

AU - Bürgi, E.

AU - Karlskov-Mortensen, Peter

AU - Andersson, L.

AU - Fredholm, Merete

AU - Vögeli, P.

PY - 2009

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N2 - Diarrhoea in newborn and weaned pigs caused by enterotoxigenic Escherichia coli (ETEC) expressing F4 fimbriae leads to considerable losses in pig production. In this study, we refined the mapping of the receptor locus for ETEC F4ab/F4ac adhesion (F4bcR) by joint analysis of Nordic and Swiss data. A total of 236 pigs from a Nordic experimental herd, 331 pigs from a Swiss experimental herd and 143 pigs from the Swiss performing station were used for linkage analysis. Genotyping data of six known microsatellite markers, two newly developed markers (MUC4gt and HSA125gt) and an intronic SNP in MUC4 (MUC4-8227) were used to create the linkage map. The region for F4bcR was refined to the interval SW207-S0075 on pig chromosome 13. The most probable position of F4bcR was in the SW207-MUC4 region. The order of six markers was supported by physical mapping on the BAC fingerprint contig from the Wellcome Trust Sanger Institute. Thus, the region for F4bcR could be reduced from 26 to 14 Mb.

AB - Diarrhoea in newborn and weaned pigs caused by enterotoxigenic Escherichia coli (ETEC) expressing F4 fimbriae leads to considerable losses in pig production. In this study, we refined the mapping of the receptor locus for ETEC F4ab/F4ac adhesion (F4bcR) by joint analysis of Nordic and Swiss data. A total of 236 pigs from a Nordic experimental herd, 331 pigs from a Swiss experimental herd and 143 pigs from the Swiss performing station were used for linkage analysis. Genotyping data of six known microsatellite markers, two newly developed markers (MUC4gt and HSA125gt) and an intronic SNP in MUC4 (MUC4-8227) were used to create the linkage map. The region for F4bcR was refined to the interval SW207-S0075 on pig chromosome 13. The most probable position of F4bcR was in the SW207-MUC4 region. The order of six markers was supported by physical mapping on the BAC fingerprint contig from the Wellcome Trust Sanger Institute. Thus, the region for F4bcR could be reduced from 26 to 14 Mb.

U2 - 10.1111/j.1365-2052.2009.01881.x

DO - 10.1111/j.1365-2052.2009.01881.x

M3 - Journal article

C2 - 19392815

SN - 0268-9146

VL - 40

SP - 749

EP - 752

JO - Animal Genetics

JF - Animal Genetics

IS - 5

ER -

Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13

Abstract

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