TY - JOUR
T1 - Reference values for leptin/adiponectin ratio in healthy children and adolescents
AU - Lausten-Thomsen, Ulrik
AU - Lund, Morten Asp Vonsild
AU - Frithioff-Bojsoe, Christine
AU - Hedley, Paula Louise
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Christiansen, Michael
AU - Holm, Jens-Christian
PY - 2019/6
Y1 - 2019/6
N2 - Background: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios.
Methods: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits.
Results: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p <.001).
Conclusion: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents
AB - Background: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios.
Methods: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits.
Results: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p <.001).
Conclusion: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents
KW - Adipokines
KW - Adiponectin
KW - Biomarkers
KW - Children
KW - Leptin
KW - Reference values
U2 - 10.1016/j.cca.2019.03.004
DO - 10.1016/j.cca.2019.03.004
M3 - Journal article
C2 - 30849308
SN - 0009-8981
VL - 493
SP - 123
EP - 128
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -