Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life

I Melle; U Haahr; Svein Friis; K Hustoft; J O Johannessen; Tor Ketil Larsen; S Opjordsmoen; B R Rund; E Simonsen; P Vaglum; T McGlashan

doi:10.1111/j.1600-0447.2005.00638.x

Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life

I Melle, U Haahr, Svein Friis, K Hustoft, J O Johannessen, Tor Ketil Larsen, S Opjordsmoen, B R Rund, E Simonsen, P Vaglum, T McGlashan

Department of Clinical Medicine

45 Citations (Scopus)

Abstract

OBJECTIVE: Long duration of untreated psychosis (DUP) is associated with poorer outcome. The TIPS study demonstrated that DUP can be reduced through early detection (ED). As quality of life (QoL) is associated with DUP it is expected that reduction of DUP leads to better QoL.

METHOD: Consecutive first-episode patients with a DSM-IV diagnosis of non-organic, non-affective psychosis were included, 281 patients gave informed consent and 263 completed a full evaluation of QoL.

RESULTS: There were no differences in subjective QoL between ED and No-ED groups attributable to reduction in DUP. There were significant bivariate differences in frequency of family and social contacts in favor of the ED group, but multivariate analyses indicated that these differences were based on differences in sample characteristics.

CONCLUSION: Deterioration in QoL may precede overt symptom formation. Focus on functional loss in ED educational campaigns may identify risk subjects earlier in the course of the disorder.

Original language	English
Book series	Acta Psychiatrica Scandinavica. Supplementum
Volume	112
Issue number	6
Pages (from-to)	469-73
Number of pages	5
ISSN	0001-690X
DOIs	https://doi.org/10.1111/j.1600-0447.2005.00638.x
Publication status	Published - Dec 2005

Keywords

Adult
Antipsychotic Agents
Female
Follow-Up Studies
Humans
Male
Prognosis
Psychotic Disorders
Quality of Life
Risk Factors
Social Behavior
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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Melle, I., Haahr, U., Friis, S., Hustoft, K., Johannessen, J. O., Larsen, T. K., Opjordsmoen, S., Rund, B. R., Simonsen, E., Vaglum, P., & McGlashan, T. (2005). Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life. Acta Psychiatrica Scandinavica. Supplementum, 112(6), 469-73. https://doi.org/10.1111/j.1600-0447.2005.00638.x

Melle, I, Haahr, U, Friis, S, Hustoft, K, Johannessen, JO, Larsen, TK, Opjordsmoen, S, Rund, BR, Simonsen, E, Vaglum, P & McGlashan, T 2005, 'Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life', Acta Psychiatrica Scandinavica. Supplementum, vol. 112, no. 6, pp. 469-73. https://doi.org/10.1111/j.1600-0447.2005.00638.x

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abstract = "OBJECTIVE: Long duration of untreated psychosis (DUP) is associated with poorer outcome. The TIPS study demonstrated that DUP can be reduced through early detection (ED). As quality of life (QoL) is associated with DUP it is expected that reduction of DUP leads to better QoL.METHOD: Consecutive first-episode patients with a DSM-IV diagnosis of non-organic, non-affective psychosis were included, 281 patients gave informed consent and 263 completed a full evaluation of QoL.RESULTS: There were no differences in subjective QoL between ED and No-ED groups attributable to reduction in DUP. There were significant bivariate differences in frequency of family and social contacts in favor of the ED group, but multivariate analyses indicated that these differences were based on differences in sample characteristics.CONCLUSION: Deterioration in QoL may precede overt symptom formation. Focus on functional loss in ED educational campaigns may identify risk subjects earlier in the course of the disorder.",

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AU - Haahr, U

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AU - Johannessen, J O

AU - Larsen, Tor Ketil

AU - Opjordsmoen, S

AU - Rund, B R

AU - Simonsen, E

AU - Vaglum, P

AU - McGlashan, T

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N2 - OBJECTIVE: Long duration of untreated psychosis (DUP) is associated with poorer outcome. The TIPS study demonstrated that DUP can be reduced through early detection (ED). As quality of life (QoL) is associated with DUP it is expected that reduction of DUP leads to better QoL.METHOD: Consecutive first-episode patients with a DSM-IV diagnosis of non-organic, non-affective psychosis were included, 281 patients gave informed consent and 263 completed a full evaluation of QoL.RESULTS: There were no differences in subjective QoL between ED and No-ED groups attributable to reduction in DUP. There were significant bivariate differences in frequency of family and social contacts in favor of the ED group, but multivariate analyses indicated that these differences were based on differences in sample characteristics.CONCLUSION: Deterioration in QoL may precede overt symptom formation. Focus on functional loss in ED educational campaigns may identify risk subjects earlier in the course of the disorder.

AB - OBJECTIVE: Long duration of untreated psychosis (DUP) is associated with poorer outcome. The TIPS study demonstrated that DUP can be reduced through early detection (ED). As quality of life (QoL) is associated with DUP it is expected that reduction of DUP leads to better QoL.METHOD: Consecutive first-episode patients with a DSM-IV diagnosis of non-organic, non-affective psychosis were included, 281 patients gave informed consent and 263 completed a full evaluation of QoL.RESULTS: There were no differences in subjective QoL between ED and No-ED groups attributable to reduction in DUP. There were significant bivariate differences in frequency of family and social contacts in favor of the ED group, but multivariate analyses indicated that these differences were based on differences in sample characteristics.CONCLUSION: Deterioration in QoL may precede overt symptom formation. Focus on functional loss in ED educational campaigns may identify risk subjects earlier in the course of the disorder.

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Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life

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Keywords

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