Reduceret cerebralt stofskifte korrelerer med MRI-forandringer og kognitiv dysfunktion hos patienter med dissemineret sklerose

M Blinkenberg; K Rune; C V Jensen; M H Ravnborg; Søren Kyllingsbæk; S Holm; O B Paulson; P S Sørensen

Reduceret cerebralt stofskifte korrelerer med MRI-forandringer og kognitiv dysfunktion hos patienter med dissemineret sklerose

Translated title of the contribution: [Reduced metabolism in cerebral cortex correlates with MRI changes and cognitive dysfunction in patients with disseminated sclerosis]

M Blinkenberg, K Rune, C V Jensen, M H Ravnborg, Søren Kyllingsbæk, S Holm, O B Paulson, P S Sørensen

8 Citations (Scopus)

Abstract

Magnetic resonance imaging (MRI) lesion load is widely used in the clinical evaluation of patients with multiple sclerosis (MS), but little is known about the associated changes in cortical activation. For this purpose, we studied the association between the corticocerebral metabolic rate of glucose (CMRglc) and the MRI T2-weighted total lesion area (TLA). In addition, we investigated the correlation between cognitive and neurological disability and CMRglc.

Translated title of the contribution	[Reduced metabolism in cerebral cortex correlates with MRI changes and cognitive dysfunction in patients with disseminated sclerosis]
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	163
Issue number	27
Pages (from-to)	3788-92
Number of pages	5
ISSN	0041-5782
Publication status	Published - 2 Jul 2001

Cite this

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title = "Reduceret cerebralt stofskifte korrelerer med MRI-forandringer og kognitiv dysfunktion hos patienter med dissemineret sklerose",

abstract = "Magnetic resonance imaging (MRI) lesion load is widely used in the clinical evaluation of patients with multiple sclerosis (MS), but little is known about the associated changes in cortical activation. For this purpose, we studied the association between the corticocerebral metabolic rate of glucose (CMRglc) and the MRI T2-weighted total lesion area (TLA). In addition, we investigated the correlation between cognitive and neurological disability and CMRglc.",

keywords = "Adult, Aged, Cerebral Cortex, Cognition Disorders, Deoxyglucose, Evoked Potentials, Motor, Female, Glucose, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Neuropsychological Tests, Tomography, Emission-Computed",

author = "M Blinkenberg and K Rune and Jensen, {C V} and Ravnborg, {M H} and S{\o}ren Kyllingsb{\ae}k and S Holm and Paulson, {O B} and S{\o}rensen, {P S}",

note = "Reduced metabolism in cerebral cortex correlates with MRI changes and cognitive dysfunction in patients with disseminated sclerosis",

year = "2001",

month = jul,

day = "2",

language = "Dansk",

volume = "163",

pages = "3788--92",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "27",

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TY - JOUR

T1 - Reduceret cerebralt stofskifte korrelerer med MRI-forandringer og kognitiv dysfunktion hos patienter med dissemineret sklerose

AU - Blinkenberg, M

AU - Rune, K

AU - Jensen, C V

AU - Ravnborg, M H

AU - Kyllingsbæk, Søren

AU - Holm, S

AU - Paulson, O B

AU - Sørensen, P S

N1 - Reduced metabolism in cerebral cortex correlates with MRI changes and cognitive dysfunction in patients with disseminated sclerosis

PY - 2001/7/2

Y1 - 2001/7/2

N2 - Magnetic resonance imaging (MRI) lesion load is widely used in the clinical evaluation of patients with multiple sclerosis (MS), but little is known about the associated changes in cortical activation. For this purpose, we studied the association between the corticocerebral metabolic rate of glucose (CMRglc) and the MRI T2-weighted total lesion area (TLA). In addition, we investigated the correlation between cognitive and neurological disability and CMRglc.

AB - Magnetic resonance imaging (MRI) lesion load is widely used in the clinical evaluation of patients with multiple sclerosis (MS), but little is known about the associated changes in cortical activation. For this purpose, we studied the association between the corticocerebral metabolic rate of glucose (CMRglc) and the MRI T2-weighted total lesion area (TLA). In addition, we investigated the correlation between cognitive and neurological disability and CMRglc.

KW - Adult

KW - Aged

KW - Cerebral Cortex

KW - Cognition Disorders

KW - Deoxyglucose

KW - Evoked Potentials, Motor

KW - Female

KW - Glucose

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Neuropsychological Tests

KW - Tomography, Emission-Computed

M3 - Tidsskriftartikel

C2 - 11466987

SN - 0041-5782

VL - 163

SP - 3788

EP - 3792

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 27

ER -

Reduceret cerebralt stofskifte korrelerer med MRI-forandringer og kognitiv dysfunktion hos patienter med dissemineret sklerose

Abstract

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