Reduced volume but increased training intensity elevates muscle Na+-K+ pump alpha1-subunit and NHE1 expression as well as short-term work capacity in humans

F. Marcello Iaia; Martin Thomassen; Helle Kolding; Thomas Gunnar Petursson Gunnarsson; Jesper Wendell; Thomas Rostgaard; Nikolai Nordsborg; Peter Krustrup; Lars Nybo; Ylva Hellsten; Jens Bangsbo

doi:10.1152/ajpregu.00666.2007

Reduced volume but increased training intensity elevates muscle Na⁺-K⁺ pump alpha₁-subunit and NHE1 expression as well as short-term work capacity in humans

F. Marcello Iaia, Martin Thomassen, Helle Kolding, Thomas Gunnar Petursson Gunnarsson, Jesper Wendell, Thomas Rostgaard, Nikolai Nordsborg, Peter Krustrup, Lars Nybo, Ylva Hellsten, Jens Bangsbo

79 Citations (Scopus)

Abstract

The present study examined muscle adaptations and alterations in work capacity in endurance-trained runners after a change from endurance to sprint training. Fifteen runners were assigned to either a sprint training (ST, n = 8) or a control (CON, n = 7) group. ST replaced their normal training by 30-s sprint runs three to four times a week, whereas CON continued the endurance training ( approximately 45 km/wk). After the 4-wk sprint period, the expression of the muscle Na(+)-K(+) pump alpha(1)-subunit and Na(+)/H(+)-exchanger isoform 1 was 29 and 30% higher (P < 0.05), respectively. Furthermore, plasma K(+) concentration was reduced (P < 0.05) during repeated intense running. In ST, performance in a 30-s sprint test, Yo-Yo intermittent recovery test, and two supramaximal exhaustive runs was improved (P < 0.05) by 7, 19, 27, and 19%, respectively, after the sprint training period, whereas pulmonary maximum oxygen uptake and 10-k time were unchanged. No changes in CON were observed. The present data suggest a role of the Na(+)-K(+) pump in the control of K(+) homeostasis and in the development of fatigue during repeated high-intensity exercise. Furthermore, performance during intense exercise can be improved and endurance performance maintained even with a reduction in training volume if the intensity of training is very high.

Original language	English
Journal	American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Volume	294
Issue number	3
Pages (from-to)	R966-R974
Number of pages	9
ISSN	0363-6119
DOIs	https://doi.org/10.1152/ajpregu.00666.2007
Publication status	Published - 2008

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Iaia, F. M., Thomassen, M., Kolding, H., Gunnarsson, T. G. P., Wendell, J., Rostgaard, T., Nordsborg, N., Krustrup, P., Nybo, L., Hellsten, Y., & Bangsbo, J. (2008). Reduced volume but increased training intensity elevates muscle Na⁺-K⁺ pump alpha₁-subunit and NHE1 expression as well as short-term work capacity in humans. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 294(3), R966-R974. https://doi.org/10.1152/ajpregu.00666.2007

Reduced volume but increased training intensity elevates muscle Na⁺-K⁺ pump alpha₁-subunit and NHE1 expression as well as short-term work capacity in humans. / Iaia, F. Marcello; Thomassen, Martin; Kolding, Helle et al.

In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 294, No. 3, 2008, p. R966-R974.

Research output: Contribution to journal › Journal article › Research › peer-review

Iaia, FM, Thomassen, M, Kolding, H, Gunnarsson, TGP, Wendell, J, Rostgaard, T, Nordsborg, N, Krustrup, P, Nybo, L , Hellsten, Y & Bangsbo, J 2008, 'Reduced volume but increased training intensity elevates muscle Na⁺-K⁺ pump alpha₁-subunit and NHE1 expression as well as short-term work capacity in humans', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 294, no. 3, pp. R966-R974. https://doi.org/10.1152/ajpregu.00666.2007

Iaia FM, Thomassen M, Kolding H, Gunnarsson TGP, Wendell J, Rostgaard T et al. Reduced volume but increased training intensity elevates muscle Na⁺-K⁺ pump alpha₁-subunit and NHE1 expression as well as short-term work capacity in humans. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2008;294(3):R966-R974. doi: 10.1152/ajpregu.00666.2007

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title = "Reduced volume but increased training intensity elevates muscle Na+-K+ pump alpha1-subunit and NHE1 expression as well as short-term work capacity in humans",

abstract = "The present study examined muscle adaptations and alterations in work capacity in endurance-trained runners after a change from endurance to sprint training. Fifteen runners were assigned to either a sprint training (ST, n = 8) or a control (CON, n = 7) group. ST replaced their normal training by 30-s sprint runs three to four times a week, whereas CON continued the endurance training ( approximately 45 km/wk). After the 4-wk sprint period, the expression of the muscle Na(+)-K(+) pump alpha(1)-subunit and Na(+)/H(+)-exchanger isoform 1 was 29 and 30% higher (P < 0.05), respectively. Furthermore, plasma K(+) concentration was reduced (P < 0.05) during repeated intense running. In ST, performance in a 30-s sprint test, Yo-Yo intermittent recovery test, and two supramaximal exhaustive runs was improved (P < 0.05) by 7, 19, 27, and 19%, respectively, after the sprint training period, whereas pulmonary maximum oxygen uptake and 10-k time were unchanged. No changes in CON were observed. The present data suggest a role of the Na(+)-K(+) pump in the control of K(+) homeostasis and in the development of fatigue during repeated high-intensity exercise. Furthermore, performance during intense exercise can be improved and endurance performance maintained even with a reduction in training volume if the intensity of training is very high.",

author = "Iaia, {F. Marcello} and Martin Thomassen and Helle Kolding and Gunnarsson, {Thomas Gunnar Petursson} and Jesper Wendell and Thomas Rostgaard and Nikolai Nordsborg and Peter Krustrup and Lars Nybo and Ylva Hellsten and Jens Bangsbo",

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T1 - Reduced volume but increased training intensity elevates muscle Na+-K+ pump alpha1-subunit and NHE1 expression as well as short-term work capacity in humans

AU - Iaia, F. Marcello

AU - Thomassen, Martin

AU - Kolding, Helle

AU - Gunnarsson, Thomas Gunnar Petursson

AU - Wendell, Jesper

AU - Rostgaard, Thomas

AU - Nordsborg, Nikolai

AU - Krustrup, Peter

AU - Nybo, Lars

AU - Hellsten, Ylva

AU - Bangsbo, Jens

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N2 - The present study examined muscle adaptations and alterations in work capacity in endurance-trained runners after a change from endurance to sprint training. Fifteen runners were assigned to either a sprint training (ST, n = 8) or a control (CON, n = 7) group. ST replaced their normal training by 30-s sprint runs three to four times a week, whereas CON continued the endurance training ( approximately 45 km/wk). After the 4-wk sprint period, the expression of the muscle Na(+)-K(+) pump alpha(1)-subunit and Na(+)/H(+)-exchanger isoform 1 was 29 and 30% higher (P < 0.05), respectively. Furthermore, plasma K(+) concentration was reduced (P < 0.05) during repeated intense running. In ST, performance in a 30-s sprint test, Yo-Yo intermittent recovery test, and two supramaximal exhaustive runs was improved (P < 0.05) by 7, 19, 27, and 19%, respectively, after the sprint training period, whereas pulmonary maximum oxygen uptake and 10-k time were unchanged. No changes in CON were observed. The present data suggest a role of the Na(+)-K(+) pump in the control of K(+) homeostasis and in the development of fatigue during repeated high-intensity exercise. Furthermore, performance during intense exercise can be improved and endurance performance maintained even with a reduction in training volume if the intensity of training is very high.

AB - The present study examined muscle adaptations and alterations in work capacity in endurance-trained runners after a change from endurance to sprint training. Fifteen runners were assigned to either a sprint training (ST, n = 8) or a control (CON, n = 7) group. ST replaced their normal training by 30-s sprint runs three to four times a week, whereas CON continued the endurance training ( approximately 45 km/wk). After the 4-wk sprint period, the expression of the muscle Na(+)-K(+) pump alpha(1)-subunit and Na(+)/H(+)-exchanger isoform 1 was 29 and 30% higher (P < 0.05), respectively. Furthermore, plasma K(+) concentration was reduced (P < 0.05) during repeated intense running. In ST, performance in a 30-s sprint test, Yo-Yo intermittent recovery test, and two supramaximal exhaustive runs was improved (P < 0.05) by 7, 19, 27, and 19%, respectively, after the sprint training period, whereas pulmonary maximum oxygen uptake and 10-k time were unchanged. No changes in CON were observed. The present data suggest a role of the Na(+)-K(+) pump in the control of K(+) homeostasis and in the development of fatigue during repeated high-intensity exercise. Furthermore, performance during intense exercise can be improved and endurance performance maintained even with a reduction in training volume if the intensity of training is very high.

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