Reduced prevalence of early preterm delivery in women with Type 1 diabetes and microalbuminuria--possible effect of early antihypertensive treatment during pregnancy

TY - JOUR

T1 - Reduced prevalence of early preterm delivery in women with Type 1 diabetes and microalbuminuria--possible effect of early antihypertensive treatment during pregnancy

AU - Nielsen, L R

AU - Kragh-Müller, Claus

AU - Damm, P

AU - Mathiesen, E R

PY - 2006/4/1

Y1 - 2006/4/1

N2 - In normotensive women with Type 1 diabetes and microalbuminuria we previously found preterm delivery (<34 weeks) in 23% of the pregnancies. Antihypertensive treatment was initiated in late pregnancy when preeclampsia was diagnosed and diastolic blood pressure > 90 mmHg. From April 2000 our routine was changed and early antihypertensive treatment with methyldopa was initiated if antihypertensive treatment was given prior to pregnancy, if urinary albumin excretion (UAE) was > 2 g/24 h, or blood pressure > 140/90 mmHg. The present study describes the impact of this more aggressive antiypertensive treatment in the prevalence of preterm delivery.

AB - In normotensive women with Type 1 diabetes and microalbuminuria we previously found preterm delivery (<34 weeks) in 23% of the pregnancies. Antihypertensive treatment was initiated in late pregnancy when preeclampsia was diagnosed and diastolic blood pressure > 90 mmHg. From April 2000 our routine was changed and early antihypertensive treatment with methyldopa was initiated if antihypertensive treatment was given prior to pregnancy, if urinary albumin excretion (UAE) was > 2 g/24 h, or blood pressure > 140/90 mmHg. The present study describes the impact of this more aggressive antiypertensive treatment in the prevalence of preterm delivery.

U2 - http://dx.doi.org/10.1111/j.1464-5491.2006.01831.x

DO - http://dx.doi.org/10.1111/j.1464-5491.2006.01831.x

M3 - Journal article

SN - 0742-3071

VL - 23

SP - 426

EP - 431

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 4

ER -