Reduced CSF CART in dementia with Lewy bodies

Kristofer Schultz; Sara Wiehager; Karin Nilsson; Jørgen E Nielsen; Suzanne G Lindquist; Lena E Hjermind; Birgitte B Andersen; Anders Wallin; Christer Nilsson; Asa Petersén

doi:10.1016/j.neulet.2009.02.008

Reduced CSF CART in dementia with Lewy bodies

Kristofer Schultz, Sara Wiehager, Karin Nilsson, Jørgen E Nielsen, Suzanne G Lindquist, Lena E Hjermind, Birgitte B Andersen, Anders Wallin, Christer Nilsson, Asa Petersén

Department of Clinical Medicine

18 Citations (Scopus)

Abstract

Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

Original language	English
Journal	Neuroscience Letters
Volume	453
Issue number	2
Pages (from-to)	104-6
Number of pages	2
ISSN	0304-3940
DOIs	https://doi.org/10.1016/j.neulet.2009.02.008
Publication status	Published - 2009

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10.1016/j.neulet.2009.02.008

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title = "Reduced CSF CART in dementia with Lewy bodies",

abstract = "Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.",

author = "Kristofer Schultz and Sara Wiehager and Karin Nilsson and Nielsen, {J{\o}rgen E} and Lindquist, {Suzanne G} and Hjermind, {Lena E} and Andersen, {Birgitte B} and Anders Wallin and Christer Nilsson and Asa Peters{\'e}n",

note = "Keywords: Aged; Alzheimer Disease; Amyloid beta-Protein; Analysis of Variance; Female; Humans; Lewy Body Disease; Male; Nerve Tissue Proteins; Peptide Fragments; Radioimmunoassay; tau Proteins",

year = "2009",

doi = "10.1016/j.neulet.2009.02.008",

language = "English",

volume = "453",

pages = "104--6",

journal = "Neuroscience Letters",

issn = "0304-3940",

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T1 - Reduced CSF CART in dementia with Lewy bodies

AU - Schultz, Kristofer

AU - Wiehager, Sara

AU - Nilsson, Karin

AU - Nielsen, Jørgen E

AU - Lindquist, Suzanne G

AU - Hjermind, Lena E

AU - Andersen, Birgitte B

AU - Wallin, Anders

AU - Nilsson, Christer

AU - Petersén, Asa

N1 - Keywords: Aged; Alzheimer Disease; Amyloid beta-Protein; Analysis of Variance; Female; Humans; Lewy Body Disease; Male; Nerve Tissue Proteins; Peptide Fragments; Radioimmunoassay; tau Proteins

PY - 2009

Y1 - 2009

N2 - Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

AB - Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

U2 - 10.1016/j.neulet.2009.02.008

DO - 10.1016/j.neulet.2009.02.008

M3 - Journal article

C2 - 19356602

SN - 0304-3940

VL - 453

SP - 104

EP - 106

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Reduced CSF CART in dementia with Lewy bodies

Abstract

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