Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia

Shoaib Afzal; Stig E Bojesen; Børge G Nordestgaard

doi:10.1016/j.jalz.2013.05.1765

Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia

Shoaib Afzal, Stig E Bojesen, Børge G Nordestgaard

Department of Clinical Medicine

104 Citations (Scopus)

Abstract

BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.

METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.

RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.

CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.

Original language	English
Journal	Alzheimer's & Dementia
Volume	10
Issue number	3
Pages (from-to)	296-302
Number of pages	7
ISSN	1552-5260
DOIs	https://doi.org/10.1016/j.jalz.2013.05.1765
Publication status	Published - May 2014

Keywords

Aged
Alzheimer Disease
Blood Chemical Analysis
Dementia, Vascular
Denmark
Female
Follow-Up Studies
Humans
Male
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
Risk
Risk Factors
Vitamin D
Vitamin D Deficiency

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10.1016/j.jalz.2013.05.1765

Cite this

@article{6ff357e26437416e91ce2e2864e7f898,

title = "Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia",

abstract = "BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.",

keywords = "Aged, Alzheimer Disease, Blood Chemical Analysis, Dementia, Vascular, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Prospective Studies, Risk, Risk Factors, Vitamin D, Vitamin D Deficiency",

author = "Shoaib Afzal and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G}",

year = "2014",

month = may,

doi = "10.1016/j.jalz.2013.05.1765",

language = "English",

volume = "10",

pages = "296--302",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia

AU - Afzal, Shoaib

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G

PY - 2014/5

Y1 - 2014/5

N2 - BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.

AB - BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.

KW - Aged

KW - Alzheimer Disease

KW - Blood Chemical Analysis

KW - Dementia, Vascular

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk

KW - Risk Factors

KW - Vitamin D

KW - Vitamin D Deficiency

U2 - 10.1016/j.jalz.2013.05.1765

DO - 10.1016/j.jalz.2013.05.1765

M3 - Journal article

C2 - 23871764

SN - 1552-5260

VL - 10

SP - 296

EP - 302

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 3

ER -

Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia

Abstract

Keywords

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