Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium

Rikki A. Cannioto; Michael J. LaMonte; Linda E Kelemen; Harvey A Risch; Kevin H Eng; Albina N. Minlikeeva; Chi-chen Hong; J Brian Szender; Lara Sucheston-Campbell; Janine M Joseph; Andrew Berchuck; Jenny Chang-Claude; Daniel W Cramer; Anna de Fazio; Brenda Diergaarde; Thilo Doerk; Jennifer A Doherty; Robert P Edwards; Brooke L Fridley; Grace Friel; Ellen L Goode; Marc T Goodman; Peter Hillemanns; Estrid Hogdall; Satoyo Hosono; Joseph L Kelley; Susanne K. Kjaer; Rüdiger Klapdor; Keitaro Matsuo; Kunle Odunsi; Christina M Nagle; Catherine M Olsen; Lisa E Paddock; Celeste L Pearce; Malcolm C Pike; Mary Anne Rossing; Barbara Schmalfeldt; Brahm H. Segal; Elizabeth A. Szamreta; Pamela J Thompson; Chiu-Chen Tseng; Robert A Vierkant; Joellen M Schildkraut; Nicolas Wentzensen; Kristine G Wicklund; Stacey J Winham; Anna H Wu; Francesmary Modugno; Roberta B Ness; Allan Jensen; Penelope M Webb; Kathryn L Terry; Elisa V Bandera; Kirsten B Moysich

doi:10.1038/bjc.2016.153

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium

Rikki A. Cannioto, Michael J. LaMonte, Linda E Kelemen, Harvey A Risch, Kevin H Eng, Albina N. Minlikeeva, Chi-chen Hong, J Brian Szender, Lara Sucheston-Campbell, Janine M Joseph, Andrew Berchuck, Jenny Chang-Claude, Daniel W Cramer, Anna de Fazio, Brenda Diergaarde, Thilo Doerk, Jennifer A Doherty, Robert P Edwards, Brooke L Fridley, Grace FrielEllen L Goode, Marc T Goodman, Peter Hillemanns, Estrid Hogdall, Satoyo Hosono, Joseph L Kelley, Susanne K. Kjaer, Rüdiger Klapdor, Keitaro Matsuo, Kunle Odunsi, Christina M Nagle, Catherine M Olsen, Lisa E Paddock, Celeste L Pearce, Malcolm C Pike, Mary Anne Rossing, Barbara Schmalfeldt, Brahm H. Segal, Elizabeth A. Szamreta, Pamela J Thompson, Chiu-Chen Tseng, Robert A Vierkant, Joellen M Schildkraut, Nicolas Wentzensen, Kristine G Wicklund, Stacey J Winham, Anna H Wu, Francesmary Modugno, Roberta B Ness, Allan Jensen, Penelope M Webb, Kathryn L Terry, Elisa V Bandera, Kirsten B Moysich

Department of Clinical Medicine

24 Citations (Scopus)

Abstract

Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

Original language	English
Journal	British Journal of Cancer
Volume	115
Issue number	1
Pages (from-to)	95-101
Number of pages	7
ISSN	0007-0920
DOIs	https://doi.org/10.1038/bjc.2016.153
Publication status	Published - 28 Jun 2016

Keywords

epithelial ovarian cancer
inactivity
mortality risk
recreational physical activity
survival

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Cannioto, R. A., LaMonte, M. J., Kelemen, L. E., Risch, H. A., Eng, K. H., Minlikeeva, A. N., Hong, C., Szender, J. B., Sucheston-Campbell, L., Joseph, J. M., Berchuck, A., Chang-Claude, J., Cramer, D. W., de Fazio, A., Diergaarde, B., Doerk, T., Doherty, J. A., Edwards, R. P., Fridley, B. L., ... Moysich, K. B. (2016). Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium. British Journal of Cancer, 115(1), 95-101. https://doi.org/10.1038/bjc.2016.153

Cannioto, RA, LaMonte, MJ, Kelemen, LE, Risch, HA, Eng, KH, Minlikeeva, AN, Hong, C, Szender, JB, Sucheston-Campbell, L, Joseph, JM, Berchuck, A, Chang-Claude, J, Cramer, DW, de Fazio, A, Diergaarde, B, Doerk, T, Doherty, JA, Edwards, RP, Fridley, BL, Friel, G, Goode, EL, Goodman, MT, Hillemanns, P, Hogdall, E, Hosono, S, Kelley, JL, Kjaer, SK, Klapdor, R, Matsuo, K, Odunsi, K, Nagle, CM, Olsen, CM, Paddock, LE, Pearce, CL, Pike, MC, Rossing, MA, Schmalfeldt, B, Segal, BH, Szamreta, EA, Thompson, PJ, Tseng, C-C, Vierkant, RA, Schildkraut, JM, Wentzensen, N, Wicklund, KG, Winham, SJ, Wu, AH, Modugno, F, Ness, RB, Jensen, A, Webb, PM, Terry, KL, Bandera, EV & Moysich, KB 2016, 'Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium', British Journal of Cancer, vol. 115, no. 1, pp. 95-101. https://doi.org/10.1038/bjc.2016.153

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title = "Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium",

abstract = "Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.",

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author = "Cannioto, {Rikki A.} and LaMonte, {Michael J.} and Kelemen, {Linda E} and Risch, {Harvey A} and Eng, {Kevin H} and Minlikeeva, {Albina N.} and Chi-chen Hong and Szender, {J Brian} and Lara Sucheston-Campbell and Joseph, {Janine M} and Andrew Berchuck and Jenny Chang-Claude and Cramer, {Daniel W} and {de Fazio}, Anna and Brenda Diergaarde and Thilo Doerk and Doherty, {Jennifer A} and Edwards, {Robert P} and Fridley, {Brooke L} and Grace Friel and Goode, {Ellen L} and Goodman, {Marc T} and Peter Hillemanns and Estrid Hogdall and Satoyo Hosono and Kelley, {Joseph L} and Kjaer, {Susanne K.} and R{\"u}diger Klapdor and Keitaro Matsuo and Kunle Odunsi and Nagle, {Christina M} and Olsen, {Catherine M} and Paddock, {Lisa E} and Pearce, {Celeste L} and Pike, {Malcolm C} and Rossing, {Mary Anne} and Barbara Schmalfeldt and Segal, {Brahm H.} and Szamreta, {Elizabeth A.} and Thompson, {Pamela J} and Chiu-Chen Tseng and Vierkant, {Robert A} and Schildkraut, {Joellen M} and Nicolas Wentzensen and Wicklund, {Kristine G} and Winham, {Stacey J} and Wu, {Anna H} and Francesmary Modugno and Ness, {Roberta B} and Allan Jensen and Webb, {Penelope M} and Terry, {Kathryn L} and Bandera, {Elisa V} and Moysich, {Kirsten B}",

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T2 - Evidence from the Ovarian Cancer Association Consortium

AU - Cannioto, Rikki A.

AU - LaMonte, Michael J.

AU - Kelemen, Linda E

AU - Risch, Harvey A

AU - Eng, Kevin H

AU - Minlikeeva, Albina N.

AU - Hong, Chi-chen

AU - Szender, J Brian

AU - Sucheston-Campbell, Lara

AU - Joseph, Janine M

AU - Berchuck, Andrew

AU - Chang-Claude, Jenny

AU - Cramer, Daniel W

AU - de Fazio, Anna

AU - Diergaarde, Brenda

AU - Doerk, Thilo

AU - Doherty, Jennifer A

AU - Edwards, Robert P

AU - Fridley, Brooke L

AU - Friel, Grace

AU - Goode, Ellen L

AU - Goodman, Marc T

AU - Hillemanns, Peter

AU - Hogdall, Estrid

AU - Hosono, Satoyo

AU - Kelley, Joseph L

AU - Kjaer, Susanne K.

AU - Klapdor, Rüdiger

AU - Matsuo, Keitaro

AU - Odunsi, Kunle

AU - Nagle, Christina M

AU - Olsen, Catherine M

AU - Paddock, Lisa E

AU - Pearce, Celeste L

AU - Pike, Malcolm C

AU - Rossing, Mary Anne

AU - Schmalfeldt, Barbara

AU - Segal, Brahm H.

AU - Szamreta, Elizabeth A.

AU - Thompson, Pamela J

AU - Tseng, Chiu-Chen

AU - Vierkant, Robert A

AU - Schildkraut, Joellen M

AU - Wentzensen, Nicolas

AU - Wicklund, Kristine G

AU - Winham, Stacey J

AU - Wu, Anna H

AU - Modugno, Francesmary

AU - Ness, Roberta B

AU - Jensen, Allan

AU - Webb, Penelope M

AU - Terry, Kathryn L

AU - Bandera, Elisa V

AU - Moysich, Kirsten B

PY - 2016/6/28

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N2 - Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

AB - Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

KW - epithelial ovarian cancer

KW - inactivity

KW - mortality risk

KW - recreational physical activity

KW - survival

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DO - 10.1038/bjc.2016.153

M3 - Letter

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SN - 0007-0920

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JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

IS - 1

ER -

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium

Abstract

Keywords

UN SDGs

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