Recognition of Peptides by Cyclodextrin Trimers

Helena Staunstrup Christensen; Bent Sigurdskjold; Tobias  Frihed; Lavinia G Marinescu-Pedersen; Christian Marcus Pedersen; Mikael Bols

Recognition of Peptides by Cyclodextrin Trimers

Helena Staunstrup Christensen, Bent Sigurdskjold, Tobias Frihed, Lavinia G Marinescu-Pedersen, Christian Marcus Pedersen, Mikael Bols

Department of Chemistry

21 Citations (Scopus)

Abstract

The efficient synthesis of a new class of cyclodextrin trimers has been carried out by using a click chemistry strategy. The cyclodextrin trimers were subsequently investigated for molecular recognition of peptides with aromatic side chains. Binding affinities for the self-assembly of different peptides to cyclodextrin trimers were determined by using real-time bimolecular interaction analyses with plasmon surface resonance. Peptides were prepared and immobilized on the sensor surface. The association constants were obtained by titration with different solutions of the cyclodextrin trimers and they were in the range of 10³ M^-1. The selectivity of molecular recognition of nonapeptides favored cyclodextrin trimers over unmodified cyclodextrin.

Original language	English
Journal	European Journal of Organic Chemistry
Volume	27
Pages (from-to)	5279-5290
ISSN	1434-193X
Publication status	Published - Sept 2011

Cite this

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title = "Recognition of Peptides by Cyclodextrin Trimers",

abstract = "The efficient synthesis of a new class of cyclodextrin trimers has been carried out by using a click chemistry strategy. The cyclodextrin trimers were subsequently investigated for molecular recognition of peptides with aromatic side chains. Binding affinities for the self-assembly of different peptides to cyclodextrin trimers were determined by using real-time bimolecular interaction analyses with plasmon surface resonance. Peptides were prepared and immobilized on the sensor surface. The association constants were obtained by titration with different solutions of the cyclodextrin trimers and they were in the range of 103 M-1. The selectivity of molecular recognition of nonapeptides favored cyclodextrin trimers over unmodified cyclodextrin.",

author = "Christensen, {Helena Staunstrup} and Bent Sigurdskjold and Tobias Frihed and Marinescu-Pedersen, {Lavinia G} and Pedersen, {Christian Marcus} and Mikael Bols",

year = "2011",

month = sep,

language = "English",

volume = "27",

pages = "5279--5290",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",

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TY - JOUR

T1 - Recognition of Peptides by Cyclodextrin Trimers

AU - Christensen, Helena Staunstrup

AU - Sigurdskjold, Bent

AU - Frihed, Tobias

AU - Marinescu-Pedersen, Lavinia G

AU - Pedersen, Christian Marcus

AU - Bols, Mikael

PY - 2011/9

Y1 - 2011/9

N2 - The efficient synthesis of a new class of cyclodextrin trimers has been carried out by using a click chemistry strategy. The cyclodextrin trimers were subsequently investigated for molecular recognition of peptides with aromatic side chains. Binding affinities for the self-assembly of different peptides to cyclodextrin trimers were determined by using real-time bimolecular interaction analyses with plasmon surface resonance. Peptides were prepared and immobilized on the sensor surface. The association constants were obtained by titration with different solutions of the cyclodextrin trimers and they were in the range of 103 M-1. The selectivity of molecular recognition of nonapeptides favored cyclodextrin trimers over unmodified cyclodextrin.

AB - The efficient synthesis of a new class of cyclodextrin trimers has been carried out by using a click chemistry strategy. The cyclodextrin trimers were subsequently investigated for molecular recognition of peptides with aromatic side chains. Binding affinities for the self-assembly of different peptides to cyclodextrin trimers were determined by using real-time bimolecular interaction analyses with plasmon surface resonance. Peptides were prepared and immobilized on the sensor surface. The association constants were obtained by titration with different solutions of the cyclodextrin trimers and they were in the range of 103 M-1. The selectivity of molecular recognition of nonapeptides favored cyclodextrin trimers over unmodified cyclodextrin.

M3 - Journal article

SN - 1434-193X

VL - 27

SP - 5279

EP - 5290

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

ER -

Recognition of Peptides by Cyclodextrin Trimers

Abstract

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