Abstract
The increasing number of poorly water-soluble drugs in development in the pharmaceutical industry has sparked interest in novel drug delivery options such as lipid-based drug delivery systems (LbDDS). Several LbDDS have been marketed successfully and have shown superior and more reliable bioavailability compared to conventional formulations. However, some reluctance in the broader application of LbDDS still appears, despite the growing commercial interest in lipids as a drug delivery platform. This reluctance might at least in part be related to the complexity associated with the development and characterization of LbDDS. In particular, the lack of standardized test protocols can be identified as the major obstacles for the broader application of LbDDS. This review seeks to summarize recent approaches in the field of lipid-based drug delivery that try to elucidate some critical steps in their development and characterization.
| Original language | English |
|---|---|
| Journal | Journal of Drug Delivery Science and Technology |
| Volume | 23 |
| Issue number | 4 |
| Pages (from-to) | 375-382 |
| Number of pages | 8 |
| ISSN | 1773-2247 |
| Publication status | Published - 1 Jul 2013 |
Keywords
- (Super-)SNEDDS
- Absorption
- In vitro lipolysis
- Lipids