Recent and ongoing selection in the human genome

Rasmus Nielsen; Ines Hellmann; Melissa Hubisz; Carlos Bustamante; Andrew G Clark

doi:10.1038/nrg2187

Recent and ongoing selection in the human genome

Rasmus Nielsen, Ines Hellmann, Melissa Hubisz, Carlos Bustamante, Andrew G Clark

Microbiology

350 Citations (Scopus)

Abstract

The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.

Original language	English
Journal	Nature Reviews. Genetics
Volume	8
Issue number	11
Pages (from-to)	857-68
Number of pages	11
ISSN	1471-0056
DOIs	https://doi.org/10.1038/nrg2187
Publication status	Published - 2007

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10.1038/nrg2187

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title = "Recent and ongoing selection in the human genome",

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author = "Rasmus Nielsen and Ines Hellmann and Melissa Hubisz and Carlos Bustamante and Clark, {Andrew G}",

note = "Keywords: Evolution, Molecular; Genetics, Population; Genome, Human; Humans; Selection (Genetics)",

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AU - Hellmann, Ines

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AU - Bustamante, Carlos

AU - Clark, Andrew G

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AB - The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.

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JO - Nature Reviews. Genetics

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Recent and ongoing selection in the human genome

Abstract

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