Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Linda E Kelemen; Elisa V Bandera; Kathryn L Terry; Mary Anne Rossing; Louise A Brinton; Jennifer A Doherty; Roberta B Ness; Susanne Kr�ger Kjaer; Jenny Chang-Claude; Martin K�bel; Galina Lurie; Pamela J Thompson; Michael E Carney; Kirsten Moysich; Robert Edwards; Clare Bunker; Allan Jensen; Estrid H�gdall; Daniel W Cramer; Allison F Vitonis; Sara H Olson; Melony King; Urmila Chandran; Jolanta Lissowska; Montserrat Garcia-Closas; Hannah Yang; Penelope M Webb; Joellen M Schildkraut; Marc T Goodman; Harvey A Risch; Australian Ovarian Cancer Study Group; Australian Cancer Study (Ovarian Cancer)

doi:10.1186/1471-2407-13-28

Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Linda E Kelemen, Elisa V Bandera, Kathryn L Terry, Mary Anne Rossing, Louise A Brinton, Jennifer A Doherty, Roberta B Ness, Susanne Kr�ger Kjaer, Jenny Chang-Claude, Martin K�bel, Galina Lurie, Pamela J Thompson, Michael E Carney, Kirsten Moysich, Robert Edwards, Clare Bunker, Allan Jensen, Estrid H�gdall, Daniel W Cramer, Allison F VitonisSara H Olson, Melony King, Urmila Chandran, Jolanta Lissowska, Montserrat Garcia-Closas, Hannah Yang, Penelope M Webb, Joellen M Schildkraut, Marc T Goodman, Harvey A Risch, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)

25 Citations (Scopus)

Abstract

Background: Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.Methods: We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.Results: Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.Conclusions: We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.

Original language	English
Article number	28
Journal	B M C Cancer
Volume	13
Number of pages	12
ISSN	1471-2407
DOIs	https://doi.org/10.1186/1471-2407-13-28
Publication status	Published - 22 Jan 2013

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Kelemen, L. E., Bandera, E. V., Terry, K. L., Rossing, M. A., Brinton, L. A., Doherty, J. A., Ness, R. B., Kjaer, S. K., Chang-Claude, J., K�bel, M., Lurie, G., Thompson, P. J., Carney, M. E., Moysich, K., Edwards, R., Bunker, C., Jensen, A., H�gdall, E., Cramer, D. W., ... Cancer), A. C. S. (2013). Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium. B M C Cancer, 13, Article 28. https://doi.org/10.1186/1471-2407-13-28

Kelemen, LE, Bandera, EV, Terry, KL, Rossing, MA, Brinton, LA, Doherty, JA, Ness, RB, Kjaer, SK, Chang-Claude, J, K�bel, M, Lurie, G, Thompson, PJ, Carney, ME, Moysich, K, Edwards, R, Bunker, C, Jensen, A, H�gdall, E, Cramer, DW, Vitonis, AF, Olson, SH, King, M, Chandran, U, Lissowska, J, Garcia-Closas, M, Yang, H, Webb, PM, Schildkraut, JM, Goodman, MT, Risch, HA, Group, AOCS & Cancer), ACS 2013, 'Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium', B M C Cancer, vol. 13, 28. https://doi.org/10.1186/1471-2407-13-28

@article{5f71dd4c8be34092ab391fd2329d1bc0,

title = "Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium",

abstract = "Background: Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.Methods: We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.Results: Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.Conclusions: We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.",

author = "Kelemen, {Linda E} and Bandera, {Elisa V} and Terry, {Kathryn L} and Rossing, {Mary Anne} and Brinton, {Louise A} and Doherty, {Jennifer A} and Ness, {Roberta B} and Kjaer, {Susanne Kr�ger} and Jenny Chang-Claude and Martin K�bel and Galina Lurie and Thompson, {Pamela J} and Carney, {Michael E} and Kirsten Moysich and Robert Edwards and Clare Bunker and Allan Jensen and Estrid H�gdall and Cramer, {Daniel W} and Vitonis, {Allison F} and Olson, {Sara H} and Melony King and Urmila Chandran and Jolanta Lissowska and Montserrat Garcia-Closas and Hannah Yang and Webb, {Penelope M} and Schildkraut, {Joellen M} and Goodman, {Marc T} and Risch, {Harvey A} and Group, {Australian Ovarian Cancer Study} and Cancer), {Australian Cancer Study (Ovarian}",

year = "2013",

month = jan,

day = "22",

doi = "10.1186/1471-2407-13-28",

language = "English",

volume = "13",

journal = "B M C Cancer",

issn = "1471-2407",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - Recent alcohol consumption and risk of incident ovarian carcinoma

T2 - a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

AU - Kelemen, Linda E

AU - Bandera, Elisa V

AU - Terry, Kathryn L

AU - Rossing, Mary Anne

AU - Brinton, Louise A

AU - Doherty, Jennifer A

AU - Ness, Roberta B

AU - Kjaer, Susanne Kr�ger

AU - Chang-Claude, Jenny

AU - K�bel, Martin

AU - Lurie, Galina

AU - Thompson, Pamela J

AU - Carney, Michael E

AU - Moysich, Kirsten

AU - Edwards, Robert

AU - Bunker, Clare

AU - Jensen, Allan

AU - H�gdall, Estrid

AU - Cramer, Daniel W

AU - Vitonis, Allison F

AU - Olson, Sara H

AU - King, Melony

AU - Chandran, Urmila

AU - Lissowska, Jolanta

AU - Garcia-Closas, Montserrat

AU - Yang, Hannah

AU - Webb, Penelope M

AU - Schildkraut, Joellen M

AU - Goodman, Marc T

AU - Risch, Harvey A

AU - Group, Australian Ovarian Cancer Study

AU - Cancer), Australian Cancer Study (Ovarian

PY - 2013/1/22

Y1 - 2013/1/22

N2 - Background: Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.Methods: We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.Results: Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.Conclusions: We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.

AB - Background: Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.Methods: We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.Results: Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.Conclusions: We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.

U2 - 10.1186/1471-2407-13-28

DO - 10.1186/1471-2407-13-28

M3 - Journal article

C2 - 23339562

SN - 1471-2407

VL - 13

JO - B M C Cancer

JF - B M C Cancer

M1 - 28

ER -

Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

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