Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology

Thomas Dirschka; Girish Gupta; Giuseppe Micali; Eggert Stockfleth; Nicole Basset-Séguin; Véronique Del Marmol; Reinhard Dummer; Gregor B E Jemec; Josep Malvehy; Ketty Peris; Susana Puig; Alexander J Stratigos; Iris Zalaudek; Giovanni Pellacani

doi:10.1080/09546634.2016.1254328

Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology

Thomas Dirschka, Girish Gupta, Giuseppe Micali, Eggert Stockfleth, Nicole Basset-Séguin, Véronique Del Marmol, Reinhard Dummer, Gregor B E Jemec, Josep Malvehy, Ketty Peris, Susana Puig, Alexander J Stratigos, Iris Zalaudek, Giovanni Pellacani

Department of Clinical Medicine

39 Citations (Scopus)

Abstract

Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology.

Original language	English
Journal	Journal of Dermatological Treatment
Volume	28
Issue number	5
Pages (from-to)	431-442
ISSN	0954-6634
DOIs	https://doi.org/10.1080/09546634.2016.1254328
Publication status	Published - 4 Jul 2017

Keywords

Algorithms
Aminoquinolines/therapeutic use
Antineoplastic Agents/therapeutic use
Combined Modality Therapy
Cryotherapy
Disease Progression
Humans
Keratosis, Actinic/diagnosis
Laser Therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/09546634.2016.1254328

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Dirschka, T., Gupta, G., Micali, G., Stockfleth, E., Basset-Séguin, N., Del Marmol, V., Dummer, R., Jemec, G. B. E., Malvehy, J., Peris, K., Puig, S., Stratigos, A. J., Zalaudek, I., & Pellacani, G. (2017). Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology. Journal of Dermatological Treatment, 28(5), 431-442. https://doi.org/10.1080/09546634.2016.1254328

Dirschka, T, Gupta, G, Micali, G, Stockfleth, E, Basset-Séguin, N, Del Marmol, V, Dummer, R, Jemec, GBE, Malvehy, J, Peris, K, Puig, S, Stratigos, AJ, Zalaudek, I & Pellacani, G 2017, 'Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology', Journal of Dermatological Treatment, vol. 28, no. 5, pp. 431-442. https://doi.org/10.1080/09546634.2016.1254328

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title = "Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology",

abstract = "Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology.",

keywords = "Algorithms, Aminoquinolines/therapeutic use, Antineoplastic Agents/therapeutic use, Combined Modality Therapy, Cryotherapy, Disease Progression, Humans, Keratosis, Actinic/diagnosis, Laser Therapy",

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T2 - practical treatment algorithm for office-based dermatology

AU - Dirschka, Thomas

AU - Gupta, Girish

AU - Micali, Giuseppe

AU - Stockfleth, Eggert

AU - Basset-Séguin, Nicole

AU - Del Marmol, Véronique

AU - Dummer, Reinhard

AU - Jemec, Gregor B E

AU - Malvehy, Josep

AU - Peris, Ketty

AU - Puig, Susana

AU - Stratigos, Alexander J

AU - Zalaudek, Iris

AU - Pellacani, Giovanni

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N2 - Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology.

AB - Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology.

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KW - Aminoquinolines/therapeutic use

KW - Antineoplastic Agents/therapeutic use

KW - Combined Modality Therapy

KW - Cryotherapy

KW - Disease Progression

KW - Humans

KW - Keratosis, Actinic/diagnosis

KW - Laser Therapy

U2 - 10.1080/09546634.2016.1254328

DO - 10.1080/09546634.2016.1254328

M3 - Review

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SN - 0954-6634

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JO - Journal of Dermatological Treatment

JF - Journal of Dermatological Treatment

IS - 5

ER -

Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology

Abstract

Keywords

UN SDGs

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