Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test

Pernille Ravn; Martin E Munk; Ase Bengaard Andersen; Bettina Lundgren; Lars N Nielsen; Troels Lillebaek; Inge J Soerensen; Peter Andersen; Karin Weldingh

Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test

Pernille Ravn, Martin E Munk, Ase Bengaard Andersen, Bettina Lundgren, Lars N Nielsen, Troels Lillebaek, Inge J Soerensen, Peter Andersen, Karin Weldingh

47 Citations (Scopus)

Abstract

A patient with polymyositis developed tuberculosis during immunosuppressive treatment. Tuberculin Skin Test and chest X-ray failed to demonstrate latent tuberculosis, whereas a blood sample that was tested with a modified QuantiFERON-TB-assay, using the recombinant ESAT-6 and CFP-10, was positive indicating that this patient was latently infected before immunosuppressive therapy. This case indicates the risk of progressing from latent to active tuberculosis given that the subject is RD1 responsive, and we believe that preventive anti-tuberculous treatment could have prevented this case of tuberculosis. We suggest that RD1 based tests are evaluated further in immunocompromised patients.

Translated title of the contribution	Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test.
Original language	English
Journal	Scandinavian Journal of Infectious Diseases
Volume	36
Issue number	6-7
Pages (from-to)	499-501
Number of pages	3
ISSN	0036-5548
Publication status	Published - 2004

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15307581&query_hl=62

Cite this

Ravn, P., Munk, M. E., Andersen, A. B., Lundgren, B., Nielsen, L. N., Lillebaek, T., Soerensen, I. J., Andersen, P., & Weldingh, K. (2004). Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test. Scandinavian Journal of Infectious Diseases, 36(6-7), 499-501. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15307581&query_hl=62

Ravn, P, Munk, ME, Andersen, AB, Lundgren, B, Nielsen, LN, Lillebaek, T, Soerensen, IJ, Andersen, P & Weldingh, K 2004, 'Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test', Scandinavian Journal of Infectious Diseases, vol. 36, no. 6-7, pp. 499-501. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15307581&query_hl=62>

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abstract = "A patient with polymyositis developed tuberculosis during immunosuppressive treatment. Tuberculin Skin Test and chest X-ray failed to demonstrate latent tuberculosis, whereas a blood sample that was tested with a modified QuantiFERON-TB-assay, using the recombinant ESAT-6 and CFP-10, was positive indicating that this patient was latently infected before immunosuppressive therapy. This case indicates the risk of progressing from latent to active tuberculosis given that the subject is RD1 responsive, and we believe that preventive anti-tuberculous treatment could have prevented this case of tuberculosis. We suggest that RD1 based tests are evaluated further in immunocompromised patients.",

author = "Pernille Ravn and Munk, {Martin E} and Andersen, {Ase Bengaard} and Bettina Lundgren and Nielsen, {Lars N} and Troels Lillebaek and Soerensen, {Inge J} and Peter Andersen and Karin Weldingh",

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AU - Ravn, Pernille

AU - Munk, Martin E

AU - Andersen, Ase Bengaard

AU - Lundgren, Bettina

AU - Nielsen, Lars N

AU - Lillebaek, Troels

AU - Soerensen, Inge J

AU - Andersen, Peter

AU - Weldingh, Karin

PY - 2004

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N2 - A patient with polymyositis developed tuberculosis during immunosuppressive treatment. Tuberculin Skin Test and chest X-ray failed to demonstrate latent tuberculosis, whereas a blood sample that was tested with a modified QuantiFERON-TB-assay, using the recombinant ESAT-6 and CFP-10, was positive indicating that this patient was latently infected before immunosuppressive therapy. This case indicates the risk of progressing from latent to active tuberculosis given that the subject is RD1 responsive, and we believe that preventive anti-tuberculous treatment could have prevented this case of tuberculosis. We suggest that RD1 based tests are evaluated further in immunocompromised patients.

AB - A patient with polymyositis developed tuberculosis during immunosuppressive treatment. Tuberculin Skin Test and chest X-ray failed to demonstrate latent tuberculosis, whereas a blood sample that was tested with a modified QuantiFERON-TB-assay, using the recombinant ESAT-6 and CFP-10, was positive indicating that this patient was latently infected before immunosuppressive therapy. This case indicates the risk of progressing from latent to active tuberculosis given that the subject is RD1 responsive, and we believe that preventive anti-tuberculous treatment could have prevented this case of tuberculosis. We suggest that RD1 based tests are evaluated further in immunocompromised patients.

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