Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Niloufar Farzan; Susanne J Vijverberg; Anand K Andiappan; Lambang Arianto; Vojko Berce; Natalia Blanca-López; Hans Bisgaard; Klaus Bønnelykke; Esteban G Burchard; Paloma Campo; Glorisa Canino; Bruce Carleton; Juan C Celedón; Fook Tim Chew; Wen Chin Chiang; Michelle M Cloutier; Denis Daley; Herman T Den Dekker; F Nicole Dijk; Liesbeth Duijts; Carlos Flores; Erick Forno; Daniel B Hawcutt; Natalia Hernandez-Pacheco; Johan C de Jongste; Michael Kabesch; Gerard H Koppelman; Vangelis G Manolopoulos; Erik Melén; Somnath Mukhopadhyay; Sara Nilsson; Colin N Palmer; Maria Pino-Yanes; Munir Pirmohamed; Uros Potočnik; Jan A Raaijmakers; Katja Repnik; Maximilian Schieck; Yang Yie Sio; Rosalind L Smyth; Csaba Szalai; Kelan G Tantisira; Steve Turner; Marc P van der Schee; Katia M Verhamme; Anke H Maitland-van der Zee

doi:10.2217/pgs-2017-0035

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Niloufar Farzan, Susanne J Vijverberg, Anand K Andiappan, Lambang Arianto, Vojko Berce, Natalia Blanca-López, Hans Bisgaard, Klaus Bønnelykke, Esteban G Burchard, Paloma Campo, Glorisa Canino, Bruce Carleton, Juan C Celedón, Fook Tim Chew, Wen Chin Chiang, Michelle M Cloutier, Denis Daley, Herman T Den Dekker, F Nicole Dijk, Liesbeth DuijtsCarlos Flores, Erick Forno, Daniel B Hawcutt, Natalia Hernandez-Pacheco, Johan C de Jongste, Michael Kabesch, Gerard H Koppelman, Vangelis G Manolopoulos, Erik Melén, Somnath Mukhopadhyay, Sara Nilsson, Colin N Palmer, Maria Pino-Yanes, Munir Pirmohamed, Uros Potočnik, Jan A Raaijmakers, Katja Repnik, Maximilian Schieck, Yang Yie Sio, Rosalind L Smyth, Csaba Szalai, Kelan G Tantisira, Steve Turner, Marc P van der Schee, Katia M Verhamme, Anke H Maitland-van der Zee

Department of Clinical Medicine

16 Citations (Scopus)

Abstract

AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.

MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.

RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.

CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.

Original language	English
Journal	Pharmacogenomics
Volume	18
Issue number	10
Pages (from-to)	931-943
Number of pages	13
ISSN	1462-2416
DOIs	https://doi.org/10.2217/pgs-2017-0035
Publication status	Published - Jul 2017

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Farzan, N., Vijverberg, S. J., Andiappan, A. K., Arianto, L., Berce, V., Blanca-López, N., Bisgaard, H., Bønnelykke, K., Burchard, E. G., Campo, P., Canino, G., Carleton, B., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Daley, D., Den Dekker, H. T., Dijk, F. N., ... Maitland-van der Zee, A. H. (2017). Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. Pharmacogenomics, 18(10), 931-943. https://doi.org/10.2217/pgs-2017-0035

Farzan, N, Vijverberg, SJ, Andiappan, AK, Arianto, L, Berce, V, Blanca-López, N, Bisgaard, H, Bønnelykke, K, Burchard, EG, Campo, P, Canino, G, Carleton, B, Celedón, JC, Chew, FT, Chiang, WC, Cloutier, MM, Daley, D, Den Dekker, HT, Dijk, FN, Duijts, L, Flores, C, Forno, E, Hawcutt, DB, Hernandez-Pacheco, N, de Jongste, JC, Kabesch, M, Koppelman, GH, Manolopoulos, VG, Melén, E, Mukhopadhyay, S, Nilsson, S, Palmer, CN, Pino-Yanes, M, Pirmohamed, M, Potočnik, U, Raaijmakers, JA, Repnik, K, Schieck, M, Sio, YY, Smyth, RL, Szalai, C, Tantisira, KG, Turner, S, van der Schee, MP, Verhamme, KM & Maitland-van der Zee, AH 2017, 'Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium', Pharmacogenomics, vol. 18, no. 10, pp. 931-943. https://doi.org/10.2217/pgs-2017-0035

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title = "Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium",

abstract = "AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.",

author = "Niloufar Farzan and Vijverberg, {Susanne J} and Andiappan, {Anand K} and Lambang Arianto and Vojko Berce and Natalia Blanca-L{\'o}pez and Hans Bisgaard and Klaus B{\o}nnelykke and Burchard, {Esteban G} and Paloma Campo and Glorisa Canino and Bruce Carleton and Celed{\'o}n, {Juan C} and Chew, {Fook Tim} and Chiang, {Wen Chin} and Cloutier, {Michelle M} and Denis Daley and {Den Dekker}, {Herman T} and Dijk, {F Nicole} and Liesbeth Duijts and Carlos Flores and Erick Forno and Hawcutt, {Daniel B} and Natalia Hernandez-Pacheco and {de Jongste}, {Johan C} and Michael Kabesch and Koppelman, {Gerard H} and Manolopoulos, {Vangelis G} and Erik Mel{\'e}n and Somnath Mukhopadhyay and Sara Nilsson and Palmer, {Colin N} and Maria Pino-Yanes and Munir Pirmohamed and Uros Poto{\v c}nik and Raaijmakers, {Jan A} and Katja Repnik and Maximilian Schieck and Sio, {Yang Yie} and Smyth, {Rosalind L} and Csaba Szalai and Tantisira, {Kelan G} and Steve Turner and {van der Schee}, {Marc P} and Verhamme, {Katia M} and {Maitland-van der Zee}, {Anke H}",

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doi = "10.2217/pgs-2017-0035",

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T1 - Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

AU - Farzan, Niloufar

AU - Vijverberg, Susanne J

AU - Andiappan, Anand K

AU - Arianto, Lambang

AU - Berce, Vojko

AU - Blanca-López, Natalia

AU - Bisgaard, Hans

AU - Bønnelykke, Klaus

AU - Burchard, Esteban G

AU - Campo, Paloma

AU - Canino, Glorisa

AU - Carleton, Bruce

AU - Celedón, Juan C

AU - Chew, Fook Tim

AU - Chiang, Wen Chin

AU - Cloutier, Michelle M

AU - Daley, Denis

AU - Den Dekker, Herman T

AU - Dijk, F Nicole

AU - Duijts, Liesbeth

AU - Flores, Carlos

AU - Forno, Erick

AU - Hawcutt, Daniel B

AU - Hernandez-Pacheco, Natalia

AU - de Jongste, Johan C

AU - Kabesch, Michael

AU - Koppelman, Gerard H

AU - Manolopoulos, Vangelis G

AU - Melén, Erik

AU - Mukhopadhyay, Somnath

AU - Nilsson, Sara

AU - Palmer, Colin N

AU - Pino-Yanes, Maria

AU - Pirmohamed, Munir

AU - Potočnik, Uros

AU - Raaijmakers, Jan A

AU - Repnik, Katja

AU - Schieck, Maximilian

AU - Sio, Yang Yie

AU - Smyth, Rosalind L

AU - Szalai, Csaba

AU - Tantisira, Kelan G

AU - Turner, Steve

AU - van der Schee, Marc P

AU - Verhamme, Katia M

AU - Maitland-van der Zee, Anke H

PY - 2017/7

Y1 - 2017/7

N2 - AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.

AB - AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.

U2 - 10.2217/pgs-2017-0035

DO - 10.2217/pgs-2017-0035

M3 - Journal article

C2 - 28639505

SN - 1462-2416

VL - 18

SP - 931

EP - 943

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 10

ER -

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Abstract

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