Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke

M O'Donnell; Damien Xavier Serpault; C Diener; R Sacco; L Lisheng; H Zhang; P Pias; T Truelsen; S L Chin; S Rangarajan; L Devilliers; A Damasceno; C Mondo; F Lanas; A Avezum; Ricardo Gredilla Diaz; J Varigos; G Hankey; P Teal; M Kapral; D Ryglewicz; A Czlonkowska; M Skowronska; P Lopez-Jaramillo; T Dans; P Langhorne; Sayed Yusuf Shah; INTERSTROKE investigators

doi:10.1159/000306058

Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke

M O'Donnell, Damien Xavier Serpault, C Diener, R Sacco, L Lisheng, H Zhang, P Pias, T Truelsen, S L Chin, S Rangarajan, L Devilliers, A Damasceno, C Mondo, F Lanas, A Avezum, Ricardo Gredilla Diaz, J Varigos, G Hankey, P Teal, M KapralD Ryglewicz, A Czlonkowska, M Skowronska, P Lopez-Jaramillo, T Dans, P Langhorne, Sayed Yusuf Shah, INTERSTROKE investigators

58 Citations (Scopus)

Abstract

Stroke is a major global health problem. It is the third leading cause of death and the leading cause of adult disability. INTERHEART, a global case-control study of acute myocardial infarction in 52 countries (29,972 participants), identified nine modifiable risk factors that accounted for >90% of population-attributable risk. However, traditional risk factors (e.g. hypertension, cholesterol) appear to exert contrasting risks for stroke compared with coronary heart disease, and the etiology of stroke is far more heterogeneous. In addition, our knowledge of risk factors for stroke in low-income countries is inadequate, where a very large burden of stroke occurs. Accordingly, a similar epidemiological study is required for stroke, to inform effective population-based strategies to reduce the risk of stroke. Methods: INTERSTROKE is an international, multicenter case-control study. Cases are patients with a first stroke within 72 h of hospital presentation in whom CT or MRI is performed. Proxy respondents are used for cases unable to communicate. Etiological and topographical stroke subtype is documented for all cases. Controls are hospital- and community-based, matched for gender, ethnicity and age (+/-5 years). A questionnaire (cases and controls) is used to acquire information on known and proposed risk factors for stroke. Cardiovascular (e.g. blood pressure) and anthropometric (e.g. waist-to-hip ratio) measurements are obtained at the time of interview. Nonfasting blood samples and random urine samples are obtained from cases and controls. Study Significance: An effective global strategy to reduce the risk of stroke mandates systematic measurement of the contribution of the major vascular risk factors within defined ethnic groups and geographical locations.

Original language	English
Journal	Neuroepidemiology
Volume	35
Issue number	1
Pages (from-to)	36-44
Number of pages	9
ISSN	0251-5350
DOIs	https://doi.org/10.1159/000306058
Publication status	Published - 1 Jul 2010

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10.1159/000306058

Cite this

O'Donnell, M., Serpault, D. X., Diener, C., Sacco, R., Lisheng, L., Zhang, H., Pias, P., Truelsen, T., Chin, S. L., Rangarajan, S., Devilliers, L., Damasceno, A., Mondo, C., Lanas, F., Avezum, A., Diaz, R. G., Varigos, J., Hankey, G., Teal, P., ... INTERSTROKE investigators (2010). Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke. Neuroepidemiology, 35(1), 36-44. https://doi.org/10.1159/000306058

O'Donnell, M, Serpault, DX, Diener, C, Sacco, R, Lisheng, L, Zhang, H, Pias, P, Truelsen, T, Chin, SL, Rangarajan, S, Devilliers, L, Damasceno, A, Mondo, C, Lanas, F, Avezum, A, Diaz, RG, Varigos, J, Hankey, G, Teal, P, Kapral, M, Ryglewicz, D, Czlonkowska, A, Skowronska, M, Lopez-Jaramillo, P, Dans, T, Langhorne, P, Shah, SY & INTERSTROKE investigators 2010, 'Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke', Neuroepidemiology, vol. 35, no. 1, pp. 36-44. https://doi.org/10.1159/000306058

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title = "Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke",

abstract = "Stroke is a major global health problem. It is the third leading cause of death and the leading cause of adult disability. INTERHEART, a global case-control study of acute myocardial infarction in 52 countries (29,972 participants), identified nine modifiable risk factors that accounted for >90% of population-attributable risk. However, traditional risk factors (e.g. hypertension, cholesterol) appear to exert contrasting risks for stroke compared with coronary heart disease, and the etiology of stroke is far more heterogeneous. In addition, our knowledge of risk factors for stroke in low-income countries is inadequate, where a very large burden of stroke occurs. Accordingly, a similar epidemiological study is required for stroke, to inform effective population-based strategies to reduce the risk of stroke. Methods: INTERSTROKE is an international, multicenter case-control study. Cases are patients with a first stroke within 72 h of hospital presentation in whom CT or MRI is performed. Proxy respondents are used for cases unable to communicate. Etiological and topographical stroke subtype is documented for all cases. Controls are hospital- and community-based, matched for gender, ethnicity and age (+/-5 years). A questionnaire (cases and controls) is used to acquire information on known and proposed risk factors for stroke. Cardiovascular (e.g. blood pressure) and anthropometric (e.g. waist-to-hip ratio) measurements are obtained at the time of interview. Nonfasting blood samples and random urine samples are obtained from cases and controls. Study Significance: An effective global strategy to reduce the risk of stroke mandates systematic measurement of the contribution of the major vascular risk factors within defined ethnic groups and geographical locations.",

author = "M O'Donnell and Serpault, {Damien Xavier} and C Diener and R Sacco and L Lisheng and H Zhang and P Pias and T Truelsen and Chin, {S L} and S Rangarajan and L Devilliers and A Damasceno and C Mondo and F Lanas and A Avezum and Diaz, {Ricardo Gredilla} and J Varigos and G Hankey and P Teal and M Kapral and D Ryglewicz and A Czlonkowska and M Skowronska and P Lopez-Jaramillo and T Dans and P Langhorne and Shah, {Sayed Yusuf} and Truelsen, {Thomas Clement}",

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T1 - Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke

AU - O'Donnell, M

AU - Serpault, Damien Xavier

AU - Diener, C

AU - Sacco, R

AU - Lisheng, L

AU - Zhang, H

AU - Pias, P

AU - Truelsen, T

AU - Chin, S L

AU - Rangarajan, S

AU - Devilliers, L

AU - Damasceno, A

AU - Mondo, C

AU - Lanas, F

AU - Avezum, A

AU - Diaz, Ricardo Gredilla

AU - Varigos, J

AU - Hankey, G

AU - Teal, P

AU - Kapral, M

AU - Ryglewicz, D

AU - Czlonkowska, A

AU - Skowronska, M

AU - Lopez-Jaramillo, P

AU - Dans, T

AU - Langhorne, P

AU - Shah, Sayed Yusuf

AU - INTERSTROKE investigators

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Stroke is a major global health problem. It is the third leading cause of death and the leading cause of adult disability. INTERHEART, a global case-control study of acute myocardial infarction in 52 countries (29,972 participants), identified nine modifiable risk factors that accounted for >90% of population-attributable risk. However, traditional risk factors (e.g. hypertension, cholesterol) appear to exert contrasting risks for stroke compared with coronary heart disease, and the etiology of stroke is far more heterogeneous. In addition, our knowledge of risk factors for stroke in low-income countries is inadequate, where a very large burden of stroke occurs. Accordingly, a similar epidemiological study is required for stroke, to inform effective population-based strategies to reduce the risk of stroke. Methods: INTERSTROKE is an international, multicenter case-control study. Cases are patients with a first stroke within 72 h of hospital presentation in whom CT or MRI is performed. Proxy respondents are used for cases unable to communicate. Etiological and topographical stroke subtype is documented for all cases. Controls are hospital- and community-based, matched for gender, ethnicity and age (+/-5 years). A questionnaire (cases and controls) is used to acquire information on known and proposed risk factors for stroke. Cardiovascular (e.g. blood pressure) and anthropometric (e.g. waist-to-hip ratio) measurements are obtained at the time of interview. Nonfasting blood samples and random urine samples are obtained from cases and controls. Study Significance: An effective global strategy to reduce the risk of stroke mandates systematic measurement of the contribution of the major vascular risk factors within defined ethnic groups and geographical locations.

AB - Stroke is a major global health problem. It is the third leading cause of death and the leading cause of adult disability. INTERHEART, a global case-control study of acute myocardial infarction in 52 countries (29,972 participants), identified nine modifiable risk factors that accounted for >90% of population-attributable risk. However, traditional risk factors (e.g. hypertension, cholesterol) appear to exert contrasting risks for stroke compared with coronary heart disease, and the etiology of stroke is far more heterogeneous. In addition, our knowledge of risk factors for stroke in low-income countries is inadequate, where a very large burden of stroke occurs. Accordingly, a similar epidemiological study is required for stroke, to inform effective population-based strategies to reduce the risk of stroke. Methods: INTERSTROKE is an international, multicenter case-control study. Cases are patients with a first stroke within 72 h of hospital presentation in whom CT or MRI is performed. Proxy respondents are used for cases unable to communicate. Etiological and topographical stroke subtype is documented for all cases. Controls are hospital- and community-based, matched for gender, ethnicity and age (+/-5 years). A questionnaire (cases and controls) is used to acquire information on known and proposed risk factors for stroke. Cardiovascular (e.g. blood pressure) and anthropometric (e.g. waist-to-hip ratio) measurements are obtained at the time of interview. Nonfasting blood samples and random urine samples are obtained from cases and controls. Study Significance: An effective global strategy to reduce the risk of stroke mandates systematic measurement of the contribution of the major vascular risk factors within defined ethnic groups and geographical locations.

U2 - 10.1159/000306058

DO - 10.1159/000306058

M3 - Journal article

SN - 0251-5350

VL - 35

SP - 36

EP - 44

JO - Neuroepidemiology

JF - Neuroepidemiology

IS - 1

ER -