Abstract
The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences.
| Original language | English |
|---|---|
| Journal | Scientific Reports |
| Volume | 4 |
| Pages (from-to) | 4020 |
| Number of pages | 1 |
| ISSN | 2045-2322 |
| DOIs | |
| Publication status | Published - 7 Feb 2014 |
Keywords
- Drug Delivery Systems
- Imaging, Three-Dimensional
- Individualized Medicine
- Individualized Medicine: methods
- Interferometry
- Interferometry: methods
- Microfluidic Analytical Techniques
- Microscopy, Interference
- Nanostructures
- Pharmaceutical Preparations
- Pharmaceutical Preparations: chemical synthesis
- Polymers
- Polymers: chemistry
- Printing
- Surface Properties