Rapid decline in glomerular filtration rate during the first weeks following heart transplantation

M Hornum; M Andersen; F Gustafsson; Peter Sandor Oturai; K Sander; S A Mortensen; Bo Friis Feldt-Rasmussen

doi:10.1016/j.transproceed.2011.02.065

Rapid decline in glomerular filtration rate during the first weeks following heart transplantation

M Hornum, M Andersen, F Gustafsson, Peter Sandor Oturai, K Sander, S A Mortensen, Bo Friis Feldt-Rasmussen

4 Citations (Scopus)

Abstract

We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.

Original language	English
Journal	Transplantation Proceedings
Volume	43
Issue number	5
Pages (from-to)	1904-7
Number of pages	4
ISSN	0041-1345
DOIs	https://doi.org/10.1016/j.transproceed.2011.02.065
Publication status	Published - Jun 2011

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title = "Rapid decline in glomerular filtration rate during the first weeks following heart transplantation",

abstract = "We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.",

author = "M Hornum and M Andersen and F Gustafsson and Oturai, {Peter Sandor} and K Sander and Mortensen, {S A} and Feldt-Rasmussen, {Bo Friis}",

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T1 - Rapid decline in glomerular filtration rate during the first weeks following heart transplantation

AU - Hornum, M

AU - Andersen, M

AU - Gustafsson, F

AU - Oturai, Peter Sandor

AU - Sander, K

AU - Mortensen, S A

AU - Feldt-Rasmussen, Bo Friis

PY - 2011/6

Y1 - 2011/6

N2 - We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.

AB - We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.

U2 - 10.1016/j.transproceed.2011.02.065

DO - 10.1016/j.transproceed.2011.02.065

M3 - Journal article

SN - 0041-1345

VL - 43

SP - 1904

EP - 1907

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 5

ER -

Rapid decline in glomerular filtration rate during the first weeks following heart transplantation

Abstract

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