Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content

M Petersen; M A Taylor; W H M Saris; C Verdich; Søren Toubro; I Macdonald; S Rössner; V Stich; B Guy-Grand; D Langin; J A Martinez; O Pedersen; C Holst; Thorkild I.A. Sørensen; Arne Astrup

doi:10.1038/sj.ijo.0803186

Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content

M Petersen, M A Taylor, W H M Saris, C Verdich, Søren Toubro, I Macdonald, S Rössner, V Stich, B Guy-Grand, D Langin, J A Martinez, O Pedersen, C Holst, Thorkild I.A. Sørensen, Arne Astrup

72 Citations (Scopus)

Abstract

OBJECTIVE: To investigate whether a hypo-energetic low-fat diet is superior to a hypo-energetic high-fat diet for the treatment of obesity. DESIGN: Open-label, 10-week dietary intervention comparing two hypo-energetic (-600 kcal/day) diets with a fat energy percent of 20-25 or 40-45.Subjects:Obese (BMI >or=30 kg/m(2)) adult subjects (n = 771), from eight European centers. MEASUREMENTS: Body weight loss, dropout rates, proportion of subjects who lost more than 10% of initial body weight, blood lipid profile, insulin and glucose. RESULTS: The dietary fat energy percent was 25% in the low-fat group and 40% in the high-fat group (mean difference: 16 (95% confidence interval (CI) 15-17)%). Average weight loss was 6.9 kg in the low-fat group and 6.6 kg in the high-fat group (mean difference: 0.3 (95% CI -0.2 to 0.8) kg). Dropout was 13.6% (n = 53) in the low-fat group and 18.3% (n = 70) in the high-fat group (P=0.001). Among completers, more subjects lost >10% in the low-fat group than in the high-fat group ((20.8%, n = 70) versus (14.7%, n = 46), P = 0.02). Fasting plasma total, low-density lipoprotein- and high-density lipoprotein-cholesterol decreased in both groups, but more so in the low-fat group than in the high-fat group. Fasting plasma insulin and glucose were lowered equally by both diets. CONCLUSIONS: The low-fat diet produced similar mean weight loss as the high-fat diet, but resulted in more subjects losing >10% of initial body weight and fewer dropouts. Both diets produced favorable changes in fasting blood lipids, insulin and glucose.

Original language	English
Journal	International Journal of Obesity
Volume	30
Issue number	3
Pages (from-to)	552-560
Number of pages	9
ISSN	0307-0565
DOIs	https://doi.org/10.1038/sj.ijo.0803186
Publication status	Published - 2006

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10.1038/sj.ijo.0803186

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Petersen, M., Taylor, M. A., Saris, W. H. M., Verdich, C., Toubro, S., Macdonald, I., Rössner, S., Stich, V., Guy-Grand, B., Langin, D., Martinez, J. A., Pedersen, O., Holst, C., Sørensen, T. I. A., & Astrup, A. (2006). Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content. International Journal of Obesity, 30(3), 552-560. https://doi.org/10.1038/sj.ijo.0803186

Petersen, M, Taylor, MA, Saris, WHM, Verdich, C, Toubro, S, Macdonald, I, Rössner, S, Stich, V, Guy-Grand, B, Langin, D, Martinez, JA, Pedersen, O, Holst, C, Sørensen, TIA & Astrup, A 2006, 'Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content', International Journal of Obesity, vol. 30, no. 3, pp. 552-560. https://doi.org/10.1038/sj.ijo.0803186

@article{95dc08c04a0911de87b8000ea68e967b,

title = "Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content",

abstract = "OBJECTIVE: To investigate whether a hypo-energetic low-fat diet is superior to a hypo-energetic high-fat diet for the treatment of obesity. DESIGN: Open-label, 10-week dietary intervention comparing two hypo-energetic (-600 kcal/day) diets with a fat energy percent of 20-25 or 40-45.Subjects:Obese (BMI >or=30 kg/m(2)) adult subjects (n = 771), from eight European centers. MEASUREMENTS: Body weight loss, dropout rates, proportion of subjects who lost more than 10% of initial body weight, blood lipid profile, insulin and glucose. RESULTS: The dietary fat energy percent was 25% in the low-fat group and 40% in the high-fat group (mean difference: 16 (95% confidence interval (CI) 15-17)%). Average weight loss was 6.9 kg in the low-fat group and 6.6 kg in the high-fat group (mean difference: 0.3 (95% CI -0.2 to 0.8) kg). Dropout was 13.6% (n = 53) in the low-fat group and 18.3% (n = 70) in the high-fat group (P=0.001). Among completers, more subjects lost >10% in the low-fat group than in the high-fat group ((20.8%, n = 70) versus (14.7%, n = 46), P = 0.02). Fasting plasma total, low-density lipoprotein- and high-density lipoprotein-cholesterol decreased in both groups, but more so in the low-fat group than in the high-fat group. Fasting plasma insulin and glucose were lowered equally by both diets. CONCLUSIONS: The low-fat diet produced similar mean weight loss as the high-fat diet, but resulted in more subjects losing >10% of initial body weight and fewer dropouts. Both diets produced favorable changes in fasting blood lipids, insulin and glucose.",

author = "M Petersen and Taylor, {M A} and Saris, {W H M} and C Verdich and S{\o}ren Toubro and I Macdonald and S R{\"o}ssner and V Stich and B Guy-Grand and D Langin and Martinez, {J A} and O Pedersen and C Holst and S{\o}rensen, {Thorkild I.A.} and Arne Astrup",

note = "Keywords: Adult; Anthropometry; Blood Glucose; Body Composition; Body Weight; Diet, Fat-Restricted; Diet, Reducing; Dietary Fats; Female; Humans; Insulin; Lipids; Male; Middle Aged; Obesity; Patient Dropouts; Treatment Outcome; Weight Loss",

year = "2006",

doi = "10.1038/sj.ijo.0803186",

language = "English",

volume = "30",

pages = "552--560",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "nature publishing group",

number = "3",

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TY - JOUR

T1 - Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content

AU - Petersen, M

AU - Taylor, M A

AU - Saris, W H M

AU - Verdich, C

AU - Toubro, Søren

AU - Macdonald, I

AU - Rössner, S

AU - Stich, V

AU - Guy-Grand, B

AU - Langin, D

AU - Martinez, J A

AU - Pedersen, O

AU - Holst, C

AU - Sørensen, Thorkild I.A.

AU - Astrup, Arne

N1 - Keywords: Adult; Anthropometry; Blood Glucose; Body Composition; Body Weight; Diet, Fat-Restricted; Diet, Reducing; Dietary Fats; Female; Humans; Insulin; Lipids; Male; Middle Aged; Obesity; Patient Dropouts; Treatment Outcome; Weight Loss

PY - 2006

Y1 - 2006

N2 - OBJECTIVE: To investigate whether a hypo-energetic low-fat diet is superior to a hypo-energetic high-fat diet for the treatment of obesity. DESIGN: Open-label, 10-week dietary intervention comparing two hypo-energetic (-600 kcal/day) diets with a fat energy percent of 20-25 or 40-45.Subjects:Obese (BMI >or=30 kg/m(2)) adult subjects (n = 771), from eight European centers. MEASUREMENTS: Body weight loss, dropout rates, proportion of subjects who lost more than 10% of initial body weight, blood lipid profile, insulin and glucose. RESULTS: The dietary fat energy percent was 25% in the low-fat group and 40% in the high-fat group (mean difference: 16 (95% confidence interval (CI) 15-17)%). Average weight loss was 6.9 kg in the low-fat group and 6.6 kg in the high-fat group (mean difference: 0.3 (95% CI -0.2 to 0.8) kg). Dropout was 13.6% (n = 53) in the low-fat group and 18.3% (n = 70) in the high-fat group (P=0.001). Among completers, more subjects lost >10% in the low-fat group than in the high-fat group ((20.8%, n = 70) versus (14.7%, n = 46), P = 0.02). Fasting plasma total, low-density lipoprotein- and high-density lipoprotein-cholesterol decreased in both groups, but more so in the low-fat group than in the high-fat group. Fasting plasma insulin and glucose were lowered equally by both diets. CONCLUSIONS: The low-fat diet produced similar mean weight loss as the high-fat diet, but resulted in more subjects losing >10% of initial body weight and fewer dropouts. Both diets produced favorable changes in fasting blood lipids, insulin and glucose.

AB - OBJECTIVE: To investigate whether a hypo-energetic low-fat diet is superior to a hypo-energetic high-fat diet for the treatment of obesity. DESIGN: Open-label, 10-week dietary intervention comparing two hypo-energetic (-600 kcal/day) diets with a fat energy percent of 20-25 or 40-45.Subjects:Obese (BMI >or=30 kg/m(2)) adult subjects (n = 771), from eight European centers. MEASUREMENTS: Body weight loss, dropout rates, proportion of subjects who lost more than 10% of initial body weight, blood lipid profile, insulin and glucose. RESULTS: The dietary fat energy percent was 25% in the low-fat group and 40% in the high-fat group (mean difference: 16 (95% confidence interval (CI) 15-17)%). Average weight loss was 6.9 kg in the low-fat group and 6.6 kg in the high-fat group (mean difference: 0.3 (95% CI -0.2 to 0.8) kg). Dropout was 13.6% (n = 53) in the low-fat group and 18.3% (n = 70) in the high-fat group (P=0.001). Among completers, more subjects lost >10% in the low-fat group than in the high-fat group ((20.8%, n = 70) versus (14.7%, n = 46), P = 0.02). Fasting plasma total, low-density lipoprotein- and high-density lipoprotein-cholesterol decreased in both groups, but more so in the low-fat group than in the high-fat group. Fasting plasma insulin and glucose were lowered equally by both diets. CONCLUSIONS: The low-fat diet produced similar mean weight loss as the high-fat diet, but resulted in more subjects losing >10% of initial body weight and fewer dropouts. Both diets produced favorable changes in fasting blood lipids, insulin and glucose.

U2 - 10.1038/sj.ijo.0803186

DO - 10.1038/sj.ijo.0803186

M3 - Journal article

C2 - 16331300

SN - 0307-0565

VL - 30

SP - 552

EP - 560

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 3

ER -

Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content

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