TY - JOUR
T1 - Randomised controlled trial of genetic amniocentesis in 4606 low-risk women.
AU - Tabor, A
AU - Philip, J
AU - Madsen, Mette
AU - Bang, J
AU - Obel, E B
AU - Nørgaard-Pedersen, B
N1 - Keywords: Abortion, Spontaneous; Adult; Amniocentesis; Clinical Trials as Topic; Female; Gestational Age; Humans; Infant, Newborn; Male; Pilot Projects; Pneumonia; Pregnancy; Pregnancy Complications; Random Allocation; Respiratory Distress Syndrome, Newborn; Time Factors; Ultrasonography; alpha-Fetoproteins
PY - 1986
Y1 - 1986
N2 - Outcome of pregnancy after amniocentesis was studied in a randomised controlled trial of 4606 women, age-range 25-34 years, without known risk of genetic disease. Spontaneous abortion rate was 1.7% in the study group after amniocentesis and 0.7% in the control group after ultrasound (relative risk 2.3). In the study group, increased levels of maternal serum alpha-fetoprotein before amniocentesis, perforation of the placenta during amniocentesis, and withdrawal of discoloured amniotic fluid were associated with an increased risk of spontaneous abortion. In the first six weeks after amniocentesis/ultrasound scan, amniotic fluid leakage occurred more often in the study group but there was no difference in the rate of vaginal bleeding. Frequency of postural malformations in the infants in the two groups was the same. In the study group, respiratory distress syndrome was diagnosed more often (relative risk 2.1) and more babies were treated for pneumonia (relative risk 2.5).
AB - Outcome of pregnancy after amniocentesis was studied in a randomised controlled trial of 4606 women, age-range 25-34 years, without known risk of genetic disease. Spontaneous abortion rate was 1.7% in the study group after amniocentesis and 0.7% in the control group after ultrasound (relative risk 2.3). In the study group, increased levels of maternal serum alpha-fetoprotein before amniocentesis, perforation of the placenta during amniocentesis, and withdrawal of discoloured amniotic fluid were associated with an increased risk of spontaneous abortion. In the first six weeks after amniocentesis/ultrasound scan, amniotic fluid leakage occurred more often in the study group but there was no difference in the rate of vaginal bleeding. Frequency of postural malformations in the infants in the two groups was the same. In the study group, respiratory distress syndrome was diagnosed more often (relative risk 2.1) and more babies were treated for pneumonia (relative risk 2.5).
M3 - Journal article
C2 - 2423826
SN - 0140-6736
VL - 1
SP - 1287
EP - 1293
JO - Lancet
JF - Lancet
IS - 8493
ER -