Ramadan model of intermittent fasting for 28 d had no major effect on body composition, glucose metabolism, or cognitive functions in healthy lean men

Nina M. Harder-Lauridsen; Astrid Rosenberg; Fabiana B. Benatti; Julie A. Damm; Carsten Thomsen; Erik L. Mortensen; Bente K. Pedersen; Rikke Krogh-Madsen

doi:10.1016/j.nut.2016.12.015

Ramadan model of intermittent fasting for 28 d had no major effect on body composition, glucose metabolism, or cognitive functions in healthy lean men

Nina M. Harder-Lauridsen^*, Astrid Rosenberg, Fabiana B. Benatti, Julie A. Damm, Carsten Thomsen, Erik L. Mortensen, Bente K. Pedersen, Rikke Krogh-Madsen

^*Corresponding author for this work

32 Citations (Scopus)

3381 Downloads (Pure)

Abstract

Objectives: There has been a parallel increase in the incidence of obesity and diabetes as well as the number of daily meals. However, evidence is lacking regarding the role of intermittent fasting. The aim of this study was to determine the effects of a Ramadan model of intermittent fasting (RIF; 14 h of daytime abstinence from food and drinking) for 28 d on body composition, glucose metabolism, and cognitive function.

Methods: Ten healthy, lean men were included in a nonrandomized, crossover, intervention study. Testing was performed before a control period of 28 d, as well as before and after 28 d of RIF. Whole-body dual-energy x-ray absorptiometry, magnetic resonance imaging of the abdomen, fitness test, oral glucose tolerance test, and cognitive function tests were performed. As secondary outcome, the participants' physical activity and 72-h glycemic responses were monitored 6 d within each of the periods. Dietary intake, appetite, and mood questionnaires also were assessed.

Results: Comparing Δ differences from testing days; body mass index changes from the control period (Δ mean: 0.2 kg/m², 95% confidence interval [CI], −2 to 0.5) and the RIF period (Δ mean: −0.3 kg/m², 95% CI, −0.6 to −0.1) were significantly different (P < 0.05). Secondary outcomes within the RIF period showed an increased area under curve (AUC) for hunger accompanied by a reduced AUC for satiety (both, P < 0.05), less mean steps per day (P < 0.05), and less positive feelings in the afternoon (P < 0.01) compared with the control period. No changes were observed in any of the other evaluated parameters.

Conclusions: Free-living participants were able to comply with 14 h of daily daytime abstinence from food and drinking for 28 d with only a minor effect on body mass index and without any effects on body composition, glucose metabolism, and cognitive function.

Original language	English
Journal	Nutrition
Volume	37
Pages (from-to)	92-103
ISSN	0899-9007
DOIs	https://doi.org/10.1016/j.nut.2016.12.015
Publication status	Published - 2017

Keywords

Body composition
Clinical
Cognitive performance
Energy restriction
Glucose
Glucose tolerance test
Insulin
Intermittent fasting
Lean
Meal frequency
Metabolism
Mood
Ramadan
Satiety

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nut.2016.12.015Licence: CC BY-NC-ND

Ramadan model of intermittent fasting for 28 d had no major effect on body composition, glucose metabolism, or cognitive functions in healthy lean menFinal published version, 1.36 MBLicence: CC BY-NC-ND

Cite this

@article{d982f93335da4d3ba5ff3d8244660464,

title = "Ramadan model of intermittent fasting for 28 d had no major effect on body composition, glucose metabolism, or cognitive functions in healthy lean men",

abstract = "Objectives: There has been a parallel increase in the incidence of obesity and diabetes as well as the number of daily meals. However, evidence is lacking regarding the role of intermittent fasting. The aim of this study was to determine the effects of a Ramadan model of intermittent fasting (RIF; 14 h of daytime abstinence from food and drinking) for 28 d on body composition, glucose metabolism, and cognitive function. Methods: Ten healthy, lean men were included in a nonrandomized, crossover, intervention study. Testing was performed before a control period of 28 d, as well as before and after 28 d of RIF. Whole-body dual-energy x-ray absorptiometry, magnetic resonance imaging of the abdomen, fitness test, oral glucose tolerance test, and cognitive function tests were performed. As secondary outcome, the participants' physical activity and 72-h glycemic responses were monitored 6 d within each of the periods. Dietary intake, appetite, and mood questionnaires also were assessed. Results: Comparing Δ differences from testing days; body mass index changes from the control period (Δ mean: 0.2 kg/m2, 95% confidence interval [CI], −2 to 0.5) and the RIF period (Δ mean: −0.3 kg/m2, 95% CI, −0.6 to −0.1) were significantly different (P < 0.05). Secondary outcomes within the RIF period showed an increased area under curve (AUC) for hunger accompanied by a reduced AUC for satiety (both, P < 0.05), less mean steps per day (P < 0.05), and less positive feelings in the afternoon (P < 0.01) compared with the control period. No changes were observed in any of the other evaluated parameters.Conclusions: Free-living participants were able to comply with 14 h of daily daytime abstinence from food and drinking for 28 d with only a minor effect on body mass index and without any effects on body composition, glucose metabolism, and cognitive function.",

keywords = "Body composition, Clinical, Cognitive performance, Energy restriction, Glucose, Glucose tolerance test, Insulin, Intermittent fasting, Lean, Meal frequency, Metabolism, Mood, Ramadan, Satiety",

author = "Harder-Lauridsen, {Nina M.} and Astrid Rosenberg and Benatti, {Fabiana B.} and Damm, {Julie A.} and Carsten Thomsen and Mortensen, {Erik L.} and Pedersen, {Bente K.} and Rikke Krogh-Madsen",

year = "2017",

doi = "10.1016/j.nut.2016.12.015",

language = "English",

volume = "37",

pages = "92--103",

journal = "Nutrition",

issn = "0899-9007",

publisher = "Elsevier",

}

TY - JOUR

T1 - Ramadan model of intermittent fasting for 28 d had no major effect on body composition, glucose metabolism, or cognitive functions in healthy lean men

AU - Harder-Lauridsen, Nina M.

AU - Rosenberg, Astrid

AU - Benatti, Fabiana B.

AU - Damm, Julie A.

AU - Thomsen, Carsten

AU - Mortensen, Erik L.

AU - Pedersen, Bente K.

AU - Krogh-Madsen, Rikke

PY - 2017

Y1 - 2017

N2 - Objectives: There has been a parallel increase in the incidence of obesity and diabetes as well as the number of daily meals. However, evidence is lacking regarding the role of intermittent fasting. The aim of this study was to determine the effects of a Ramadan model of intermittent fasting (RIF; 14 h of daytime abstinence from food and drinking) for 28 d on body composition, glucose metabolism, and cognitive function. Methods: Ten healthy, lean men were included in a nonrandomized, crossover, intervention study. Testing was performed before a control period of 28 d, as well as before and after 28 d of RIF. Whole-body dual-energy x-ray absorptiometry, magnetic resonance imaging of the abdomen, fitness test, oral glucose tolerance test, and cognitive function tests were performed. As secondary outcome, the participants' physical activity and 72-h glycemic responses were monitored 6 d within each of the periods. Dietary intake, appetite, and mood questionnaires also were assessed. Results: Comparing Δ differences from testing days; body mass index changes from the control period (Δ mean: 0.2 kg/m2, 95% confidence interval [CI], −2 to 0.5) and the RIF period (Δ mean: −0.3 kg/m2, 95% CI, −0.6 to −0.1) were significantly different (P < 0.05). Secondary outcomes within the RIF period showed an increased area under curve (AUC) for hunger accompanied by a reduced AUC for satiety (both, P < 0.05), less mean steps per day (P < 0.05), and less positive feelings in the afternoon (P < 0.01) compared with the control period. No changes were observed in any of the other evaluated parameters.Conclusions: Free-living participants were able to comply with 14 h of daily daytime abstinence from food and drinking for 28 d with only a minor effect on body mass index and without any effects on body composition, glucose metabolism, and cognitive function.

AB - Objectives: There has been a parallel increase in the incidence of obesity and diabetes as well as the number of daily meals. However, evidence is lacking regarding the role of intermittent fasting. The aim of this study was to determine the effects of a Ramadan model of intermittent fasting (RIF; 14 h of daytime abstinence from food and drinking) for 28 d on body composition, glucose metabolism, and cognitive function. Methods: Ten healthy, lean men were included in a nonrandomized, crossover, intervention study. Testing was performed before a control period of 28 d, as well as before and after 28 d of RIF. Whole-body dual-energy x-ray absorptiometry, magnetic resonance imaging of the abdomen, fitness test, oral glucose tolerance test, and cognitive function tests were performed. As secondary outcome, the participants' physical activity and 72-h glycemic responses were monitored 6 d within each of the periods. Dietary intake, appetite, and mood questionnaires also were assessed. Results: Comparing Δ differences from testing days; body mass index changes from the control period (Δ mean: 0.2 kg/m2, 95% confidence interval [CI], −2 to 0.5) and the RIF period (Δ mean: −0.3 kg/m2, 95% CI, −0.6 to −0.1) were significantly different (P < 0.05). Secondary outcomes within the RIF period showed an increased area under curve (AUC) for hunger accompanied by a reduced AUC for satiety (both, P < 0.05), less mean steps per day (P < 0.05), and less positive feelings in the afternoon (P < 0.01) compared with the control period. No changes were observed in any of the other evaluated parameters.Conclusions: Free-living participants were able to comply with 14 h of daily daytime abstinence from food and drinking for 28 d with only a minor effect on body mass index and without any effects on body composition, glucose metabolism, and cognitive function.

KW - Body composition

KW - Clinical

KW - Cognitive performance

KW - Energy restriction

KW - Glucose

KW - Glucose tolerance test

KW - Insulin

KW - Intermittent fasting

KW - Lean

KW - Meal frequency

KW - Metabolism

KW - Mood

KW - Ramadan

KW - Satiety

U2 - 10.1016/j.nut.2016.12.015

DO - 10.1016/j.nut.2016.12.015

M3 - Journal article

C2 - 28359370

AN - SCOPUS:85016227819

SN - 0899-9007

VL - 37

SP - 92

EP - 103

JO - Nutrition

JF - Nutrition

ER -