Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

Katja M Heinemeier; Peter Schjerling; Jan Heinemeier; Mathias B Møller; Michael R Krogsgaard; Tomas Grum-Schwensen; Michael M Petersen; Michael Kjaer

doi:10.1126/scitranslmed.aad8335

Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

Katja M Heinemeier, Peter Schjerling, Jan Heinemeier, Mathias B Møller, Michael R Krogsgaard, Tomas Grum-Schwensen, Michael M Petersen, Michael Kjaer

64 Citations (Scopus)

Abstract

The poor regenerative capacity of articular cartilage presents a major clinical challenge and may relate to a limited turnover of the cartilage collagen matrix. However, the collagen turnover rate during life is not clear, and it is debated whether osteoarthritis (OA) can influence it. Using the carbon-14 ((14)C) bomb-pulse method, life-long replacement rates of collagen were measured in tibial plateau cartilage from 23 persons born between 1935 and1997 (15 and 8 persons with OA and healthy cartilage, respectively). The (14)C levels observed in cartilage collagen showed that, virtually, no replacement of the collagen matrix happened after skeletal maturity and that neither OA nor tissue damage, per se, influenced collagen turnover. Regional differences in (14)C content across the joint surface showed that cartilage collagen located centrally on the joint surface is formed several years earlier than collagen located peripherally. The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease.

Original language	English
Article number	346ra90
Journal	Science Translational Medicine
Volume	8
Issue number	346
ISSN	1946-6234
DOIs	https://doi.org/10.1126/scitranslmed.aad8335
Publication status	Published - 6 Jul 2016

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1126/scitranslmed.aad8335

Cite this

@article{bd6be3d07a6a4dd890591411d1f8487f,

title = "Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage",

abstract = "The poor regenerative capacity of articular cartilage presents a major clinical challenge and may relate to a limited turnover of the cartilage collagen matrix. However, the collagen turnover rate during life is not clear, and it is debated whether osteoarthritis (OA) can influence it. Using the carbon-14 ((14)C) bomb-pulse method, life-long replacement rates of collagen were measured in tibial plateau cartilage from 23 persons born between 1935 and1997 (15 and 8 persons with OA and healthy cartilage, respectively). The (14)C levels observed in cartilage collagen showed that, virtually, no replacement of the collagen matrix happened after skeletal maturity and that neither OA nor tissue damage, per se, influenced collagen turnover. Regional differences in (14)C content across the joint surface showed that cartilage collagen located centrally on the joint surface is formed several years earlier than collagen located peripherally. The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease.",

keywords = "Journal Article",

author = "Heinemeier, {Katja M} and Peter Schjerling and Jan Heinemeier and M{\o}ller, {Mathias B} and Krogsgaard, {Michael R} and Tomas Grum-Schwensen and Petersen, {Michael M} and Michael Kjaer",

note = "Copyright {\textcopyright} 2016, American Association for the Advancement of Science.",

year = "2016",

month = jul,

day = "6",

doi = "10.1126/scitranslmed.aad8335",

language = "English",

volume = "8",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "american association for the advancement of science",

number = "346",

}

TY - JOUR

T1 - Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

AU - Heinemeier, Katja M

AU - Schjerling, Peter

AU - Heinemeier, Jan

AU - Møller, Mathias B

AU - Krogsgaard, Michael R

AU - Grum-Schwensen, Tomas

AU - Petersen, Michael M

AU - Kjaer, Michael

PY - 2016/7/6

Y1 - 2016/7/6

N2 - The poor regenerative capacity of articular cartilage presents a major clinical challenge and may relate to a limited turnover of the cartilage collagen matrix. However, the collagen turnover rate during life is not clear, and it is debated whether osteoarthritis (OA) can influence it. Using the carbon-14 ((14)C) bomb-pulse method, life-long replacement rates of collagen were measured in tibial plateau cartilage from 23 persons born between 1935 and1997 (15 and 8 persons with OA and healthy cartilage, respectively). The (14)C levels observed in cartilage collagen showed that, virtually, no replacement of the collagen matrix happened after skeletal maturity and that neither OA nor tissue damage, per se, influenced collagen turnover. Regional differences in (14)C content across the joint surface showed that cartilage collagen located centrally on the joint surface is formed several years earlier than collagen located peripherally. The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease.

AB - The poor regenerative capacity of articular cartilage presents a major clinical challenge and may relate to a limited turnover of the cartilage collagen matrix. However, the collagen turnover rate during life is not clear, and it is debated whether osteoarthritis (OA) can influence it. Using the carbon-14 ((14)C) bomb-pulse method, life-long replacement rates of collagen were measured in tibial plateau cartilage from 23 persons born between 1935 and1997 (15 and 8 persons with OA and healthy cartilage, respectively). The (14)C levels observed in cartilage collagen showed that, virtually, no replacement of the collagen matrix happened after skeletal maturity and that neither OA nor tissue damage, per se, influenced collagen turnover. Regional differences in (14)C content across the joint surface showed that cartilage collagen located centrally on the joint surface is formed several years earlier than collagen located peripherally. The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease.

KW - Journal Article

U2 - 10.1126/scitranslmed.aad8335

DO - 10.1126/scitranslmed.aad8335

M3 - Journal article

C2 - 27384346

SN - 1946-6234

VL - 8

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 346

M1 - 346ra90

ER -

Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this