Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease

Nora Elisabeth Zois; A. Tidholm; K.M. Nägga; S.G. Moesgaard; Caroline Elisabeth Rasmussen; Bo Torkel Falk; J. Häggström; H.D. Pedersen; B. Åblad; H.Y. Nilsen; Lisbeth Høier Olsen

doi:10.1111/j.1939-1676.2012.01017.x

Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease

Nora Elisabeth Zois, A. Tidholm, K.M. Nägga, S.G. Moesgaard, Caroline Elisabeth Rasmussen, Bo Torkel Falk, J. Häggström, H.D. Pedersen, B. Åblad, H.Y. Nilsen, Lisbeth Høier Olsen

Lifepharm

22 Citations (Scopus)

Abstract

Background: Assessment of left ventricular (LV) function using conventional echocardiographic methods is difficult in mitral regurgitation (MR) owing to altered hemodynamic loading conditions. Newer methods such as speckle-tracking echocardiography (STE) provide assessment of LV strain (St) and strain rates (SR). Hypotheses: Global St and SR are 1) decreased in dogs with clinical signs of congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) compared with clinically healthy dogs, and are 2) associated with conventional echocardiographic indices of MMVD severity. Animals: The study subjects were 93 privately owned dogs with different MMVD severities. Methods: Prospectively recruited dogs were grouped according to MMVD severity based on echocardiographic evaluation of MR and presence of clinical signs. Global radial and longitudinal St, SR, and indices of LV dyssynchrony were assessed. Results: On group-wise comparisons, dogs with CHF had increased global longitudinal St, global longitudinal and radial SR in systole (SRs), and early diastole (SRe) compared with dogs with no or minimal MR (all P < .04). On multiple regression analyses, these global STE variables increased with degree of MR, but associations with left atrial-to-aortic root ratio (LA/Ao) were best described by second-order polynomial equations. Thus, curvilinear relationships were found for LA/Ao and longitudinal St, SRs, and SRe (all P < .002) and radial St and SRe (all P < .001). Conclusions and Clinical Importance: Assessed by STE, LV function appeared to be augmented in moderate-to-severe disease. However, at CHF stages with greatly enlarged atria, a decrease to levels comparable to dogs with no or minimal MR was observed.

Original language	English
Journal	Journal of Veterinary Internal Medicine
Volume	26
Issue number	6
Pages (from-to)	1309-1319
Number of pages	11
ISSN	0891-6640
DOIs	https://doi.org/10.1111/j.1939-1676.2012.01017.x
Publication status	Published - Nov 2012

Keywords

Former LIFE faculty

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Zois, N. E., Tidholm, A., Nägga, K. M., Moesgaard, S. G., Rasmussen, C. E., Falk, B. T., Häggström, J., Pedersen, H. D., Åblad, B., Nilsen, H. Y., & Olsen, L. H. (2012). Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease. Journal of Veterinary Internal Medicine, 26(6), 1309-1319. https://doi.org/10.1111/j.1939-1676.2012.01017.x

Zois, NE, Tidholm, A, Nägga, KM, Moesgaard, SG, Rasmussen, CE, Falk, BT, Häggström, J, Pedersen, HD, Åblad, B, Nilsen, HY & Olsen, LH 2012, 'Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease', Journal of Veterinary Internal Medicine, vol. 26, no. 6, pp. 1309-1319. https://doi.org/10.1111/j.1939-1676.2012.01017.x

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title = "Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease",

abstract = "Background: Assessment of left ventricular (LV) function using conventional echocardiographic methods is difficult in mitral regurgitation (MR) owing to altered hemodynamic loading conditions. Newer methods such as speckle-tracking echocardiography (STE) provide assessment of LV strain (St) and strain rates (SR). Hypotheses: Global St and SR are 1) decreased in dogs with clinical signs of congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) compared with clinically healthy dogs, and are 2) associated with conventional echocardiographic indices of MMVD severity. Animals: The study subjects were 93 privately owned dogs with different MMVD severities. Methods: Prospectively recruited dogs were grouped according to MMVD severity based on echocardiographic evaluation of MR and presence of clinical signs. Global radial and longitudinal St, SR, and indices of LV dyssynchrony were assessed. Results: On group-wise comparisons, dogs with CHF had increased global longitudinal St, global longitudinal and radial SR in systole (SRs), and early diastole (SRe) compared with dogs with no or minimal MR (all P < .04). On multiple regression analyses, these global STE variables increased with degree of MR, but associations with left atrial-to-aortic root ratio (LA/Ao) were best described by second-order polynomial equations. Thus, curvilinear relationships were found for LA/Ao and longitudinal St, SRs, and SRe (all P < .002) and radial St and SRe (all P < .001). Conclusions and Clinical Importance: Assessed by STE, LV function appeared to be augmented in moderate-to-severe disease. However, at CHF stages with greatly enlarged atria, a decrease to levels comparable to dogs with no or minimal MR was observed.",

keywords = "Former LIFE faculty, Deformation, Deformation Rate, Mitral regurgitation, Ventricular function",

author = "Zois, {Nora Elisabeth} and A. Tidholm and K.M. N{\"a}gga and S.G. Moesgaard and Rasmussen, {Caroline Elisabeth} and Falk, {Bo Torkel} and J. H{\"a}ggstr{\"o}m and H.D. Pedersen and B. {\AA}blad and H.Y. Nilsen and Olsen, {Lisbeth H{\o}ier}",

note = "Copyright {\textcopyright} 2012 by the American College of Veterinary Internal Medicine.",

year = "2012",

month = nov,

doi = "10.1111/j.1939-1676.2012.01017.x",

language = "English",

volume = "26",

pages = "1309--1319",

journal = "Journal of Veterinary Internal Medicine",

issn = "0891-6640",

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TY - JOUR

T1 - Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease

AU - Zois, Nora Elisabeth

AU - Tidholm, A.

AU - Nägga, K.M.

AU - Moesgaard, S.G.

AU - Rasmussen, Caroline Elisabeth

AU - Falk, Bo Torkel

AU - Häggström, J.

AU - Pedersen, H.D.

AU - Åblad, B.

AU - Nilsen, H.Y.

AU - Olsen, Lisbeth Høier

PY - 2012/11

Y1 - 2012/11

N2 - Background: Assessment of left ventricular (LV) function using conventional echocardiographic methods is difficult in mitral regurgitation (MR) owing to altered hemodynamic loading conditions. Newer methods such as speckle-tracking echocardiography (STE) provide assessment of LV strain (St) and strain rates (SR). Hypotheses: Global St and SR are 1) decreased in dogs with clinical signs of congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) compared with clinically healthy dogs, and are 2) associated with conventional echocardiographic indices of MMVD severity. Animals: The study subjects were 93 privately owned dogs with different MMVD severities. Methods: Prospectively recruited dogs were grouped according to MMVD severity based on echocardiographic evaluation of MR and presence of clinical signs. Global radial and longitudinal St, SR, and indices of LV dyssynchrony were assessed. Results: On group-wise comparisons, dogs with CHF had increased global longitudinal St, global longitudinal and radial SR in systole (SRs), and early diastole (SRe) compared with dogs with no or minimal MR (all P < .04). On multiple regression analyses, these global STE variables increased with degree of MR, but associations with left atrial-to-aortic root ratio (LA/Ao) were best described by second-order polynomial equations. Thus, curvilinear relationships were found for LA/Ao and longitudinal St, SRs, and SRe (all P < .002) and radial St and SRe (all P < .001). Conclusions and Clinical Importance: Assessed by STE, LV function appeared to be augmented in moderate-to-severe disease. However, at CHF stages with greatly enlarged atria, a decrease to levels comparable to dogs with no or minimal MR was observed.

AB - Background: Assessment of left ventricular (LV) function using conventional echocardiographic methods is difficult in mitral regurgitation (MR) owing to altered hemodynamic loading conditions. Newer methods such as speckle-tracking echocardiography (STE) provide assessment of LV strain (St) and strain rates (SR). Hypotheses: Global St and SR are 1) decreased in dogs with clinical signs of congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) compared with clinically healthy dogs, and are 2) associated with conventional echocardiographic indices of MMVD severity. Animals: The study subjects were 93 privately owned dogs with different MMVD severities. Methods: Prospectively recruited dogs were grouped according to MMVD severity based on echocardiographic evaluation of MR and presence of clinical signs. Global radial and longitudinal St, SR, and indices of LV dyssynchrony were assessed. Results: On group-wise comparisons, dogs with CHF had increased global longitudinal St, global longitudinal and radial SR in systole (SRs), and early diastole (SRe) compared with dogs with no or minimal MR (all P < .04). On multiple regression analyses, these global STE variables increased with degree of MR, but associations with left atrial-to-aortic root ratio (LA/Ao) were best described by second-order polynomial equations. Thus, curvilinear relationships were found for LA/Ao and longitudinal St, SRs, and SRe (all P < .002) and radial St and SRe (all P < .001). Conclusions and Clinical Importance: Assessed by STE, LV function appeared to be augmented in moderate-to-severe disease. However, at CHF stages with greatly enlarged atria, a decrease to levels comparable to dogs with no or minimal MR was observed.

KW - Former LIFE faculty

KW - Deformation

KW - Deformation Rate

KW - Mitral regurgitation

KW - Ventricular function

U2 - 10.1111/j.1939-1676.2012.01017.x

DO - 10.1111/j.1939-1676.2012.01017.x

M3 - Journal article

C2 - 23113772

SN - 0891-6640

VL - 26

SP - 1309

EP - 1319

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

IS - 6

ER -

Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease

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