Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes

Thomas S Hermann; Weijie Li; Helena Dominguez; Nikolaj Ihlemann; Christian Rask-Madsen; Atheline Major-Pedersen; Dorthe Baunbjerg Nielsen; Kaj Winther Hansen; Meredith Hawkins; Lars Kober; Christian Torp-Pedersen

doi:10.1210/jc.2005-1231

Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes

Thomas S Hermann, Weijie Li, Helena Dominguez, Nikolaj Ihlemann, Christian Rask-Madsen, Atheline Major-Pedersen, Dorthe Baunbjerg Nielsen, Kaj Winther Hansen, Meredith Hawkins, Lars Kober, Christian Torp-Pedersen

Department of Clinical Medicine

54 Citations (Scopus)

Abstract

OBJECTIVE: Angiotensin-converting enzyme inhibitors reduce cardiovascular mortality and improve endothelial function in type 2 diabetic patients. We hypothesized that 2 months of quinapril treatment would improve insulin-stimulated endothelial function and glucose uptake in type 2 diabetic subjects and simultaneously increase the expression of genes that are pertinent for endothelial function and metabolism. METHODS: Twenty-four type 2 diabetic subjects were randomized to receive 2 months of quinapril 20 mg daily or no treatment in an open parallel study. Endothelium-dependent and -independent vasodilation was studied during serotonin or sodium nitroprusside infusion in the diabetic patients and in 15 healthy subjects. Endothelial function, insulin-stimulated endothelial function, and insulin-stimulated glucose uptake were measured before and after quinapril treatment. Blood flow was measured by venous occlusion plethysmography. Gene expression was measured by real-time PCR. RESULTS: Quinapril treatment increased insulin-stimulated endothelial function in the type 2 diabetic subjects (P = 0.005), whereas forearm glucose uptake was unchanged. Endothelial function was also increased by quinapril (P = 0.001). Systolic and diastolic blood pressures were reduced by quinapril (P < 0.001). Quinapril increased adiponectin gene expression in vascular tissue obtained from sc adipose biopsies. CONCLUSIONS: Quinapril treatment increases insulin-stimulated endothelial function in patients with type 2 diabetes. Increased vascular adiponectin gene expression may contribute to this beneficial effect.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	91
Issue number	3
Pages (from-to)	1001-8
Number of pages	7
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2005-1231
Publication status	Published - 2005

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10.1210/jc.2005-1231

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Hermann, T. S., Li, W., Dominguez, H., Ihlemann, N., Rask-Madsen, C., Major-Pedersen, A., Nielsen, D. B., Hansen, K. W., Hawkins, M., Kober, L., & Torp-Pedersen, C. (2005). Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 91(3), 1001-8. https://doi.org/10.1210/jc.2005-1231

Hermann, TS, Li, W, Dominguez, H, Ihlemann, N, Rask-Madsen, C, Major-Pedersen, A, Nielsen, DB, Hansen, KW, Hawkins, M, Kober, L & Torp-Pedersen, C 2005, 'Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes', Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 3, pp. 1001-8. https://doi.org/10.1210/jc.2005-1231

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title = "Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes",

abstract = "OBJECTIVE: Angiotensin-converting enzyme inhibitors reduce cardiovascular mortality and improve endothelial function in type 2 diabetic patients. We hypothesized that 2 months of quinapril treatment would improve insulin-stimulated endothelial function and glucose uptake in type 2 diabetic subjects and simultaneously increase the expression of genes that are pertinent for endothelial function and metabolism. METHODS: Twenty-four type 2 diabetic subjects were randomized to receive 2 months of quinapril 20 mg daily or no treatment in an open parallel study. Endothelium-dependent and -independent vasodilation was studied during serotonin or sodium nitroprusside infusion in the diabetic patients and in 15 healthy subjects. Endothelial function, insulin-stimulated endothelial function, and insulin-stimulated glucose uptake were measured before and after quinapril treatment. Blood flow was measured by venous occlusion plethysmography. Gene expression was measured by real-time PCR. RESULTS: Quinapril treatment increased insulin-stimulated endothelial function in the type 2 diabetic subjects (P = 0.005), whereas forearm glucose uptake was unchanged. Endothelial function was also increased by quinapril (P = 0.001). Systolic and diastolic blood pressures were reduced by quinapril (P < 0.001). Quinapril increased adiponectin gene expression in vascular tissue obtained from sc adipose biopsies. CONCLUSIONS: Quinapril treatment increases insulin-stimulated endothelial function in patients with type 2 diabetes. Increased vascular adiponectin gene expression may contribute to this beneficial effect.",

author = "Hermann, {Thomas S} and Weijie Li and Helena Dominguez and Nikolaj Ihlemann and Christian Rask-Madsen and Atheline Major-Pedersen and Nielsen, {Dorthe Baunbjerg} and Hansen, {Kaj Winther} and Meredith Hawkins and Lars Kober and Christian Torp-Pedersen",

note = "Keywords: Adiponectin; Angiotensin-Converting Enzyme Inhibitors; Base Sequence; Blood Pressure; DNA Primers; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Gene Expression Regulation; Heart Rate; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Polymerase Chain Reaction; Tetrahydroisoquinolines",

year = "2005",

doi = "10.1210/jc.2005-1231",

language = "English",

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pages = "1001--8",

journal = "Journal of Clinical Endocrinology and Metabolism",

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T1 - Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes

AU - Hermann, Thomas S

AU - Li, Weijie

AU - Dominguez, Helena

AU - Ihlemann, Nikolaj

AU - Rask-Madsen, Christian

AU - Major-Pedersen, Atheline

AU - Nielsen, Dorthe Baunbjerg

AU - Hansen, Kaj Winther

AU - Hawkins, Meredith

AU - Kober, Lars

AU - Torp-Pedersen, Christian

N1 - Keywords: Adiponectin; Angiotensin-Converting Enzyme Inhibitors; Base Sequence; Blood Pressure; DNA Primers; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Gene Expression Regulation; Heart Rate; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Polymerase Chain Reaction; Tetrahydroisoquinolines

PY - 2005

Y1 - 2005

N2 - OBJECTIVE: Angiotensin-converting enzyme inhibitors reduce cardiovascular mortality and improve endothelial function in type 2 diabetic patients. We hypothesized that 2 months of quinapril treatment would improve insulin-stimulated endothelial function and glucose uptake in type 2 diabetic subjects and simultaneously increase the expression of genes that are pertinent for endothelial function and metabolism. METHODS: Twenty-four type 2 diabetic subjects were randomized to receive 2 months of quinapril 20 mg daily or no treatment in an open parallel study. Endothelium-dependent and -independent vasodilation was studied during serotonin or sodium nitroprusside infusion in the diabetic patients and in 15 healthy subjects. Endothelial function, insulin-stimulated endothelial function, and insulin-stimulated glucose uptake were measured before and after quinapril treatment. Blood flow was measured by venous occlusion plethysmography. Gene expression was measured by real-time PCR. RESULTS: Quinapril treatment increased insulin-stimulated endothelial function in the type 2 diabetic subjects (P = 0.005), whereas forearm glucose uptake was unchanged. Endothelial function was also increased by quinapril (P = 0.001). Systolic and diastolic blood pressures were reduced by quinapril (P < 0.001). Quinapril increased adiponectin gene expression in vascular tissue obtained from sc adipose biopsies. CONCLUSIONS: Quinapril treatment increases insulin-stimulated endothelial function in patients with type 2 diabetes. Increased vascular adiponectin gene expression may contribute to this beneficial effect.

AB - OBJECTIVE: Angiotensin-converting enzyme inhibitors reduce cardiovascular mortality and improve endothelial function in type 2 diabetic patients. We hypothesized that 2 months of quinapril treatment would improve insulin-stimulated endothelial function and glucose uptake in type 2 diabetic subjects and simultaneously increase the expression of genes that are pertinent for endothelial function and metabolism. METHODS: Twenty-four type 2 diabetic subjects were randomized to receive 2 months of quinapril 20 mg daily or no treatment in an open parallel study. Endothelium-dependent and -independent vasodilation was studied during serotonin or sodium nitroprusside infusion in the diabetic patients and in 15 healthy subjects. Endothelial function, insulin-stimulated endothelial function, and insulin-stimulated glucose uptake were measured before and after quinapril treatment. Blood flow was measured by venous occlusion plethysmography. Gene expression was measured by real-time PCR. RESULTS: Quinapril treatment increased insulin-stimulated endothelial function in the type 2 diabetic subjects (P = 0.005), whereas forearm glucose uptake was unchanged. Endothelial function was also increased by quinapril (P = 0.001). Systolic and diastolic blood pressures were reduced by quinapril (P < 0.001). Quinapril increased adiponectin gene expression in vascular tissue obtained from sc adipose biopsies. CONCLUSIONS: Quinapril treatment increases insulin-stimulated endothelial function in patients with type 2 diabetes. Increased vascular adiponectin gene expression may contribute to this beneficial effect.

U2 - 10.1210/jc.2005-1231

DO - 10.1210/jc.2005-1231

M3 - Journal article

C2 - 16352688

SN - 0021-972X

VL - 91

SP - 1001

EP - 1008

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 3

ER -

Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes

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