QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.

Tuulikki Sokka; Hannu Kautiainen; Sergio Toloza; Heidi Mäkinen; Suzan M M Verstappen; Merete Lund Hetland; Antonio Naranjo; Eva Baecklund; Gertraud Herborn; Rolf Rau; Massimiliano Cazzato; Laure Gossec; Vlado Skakic; Feride Gogus; Stanislaw Sierakowski; Barry Bresnihan; Peter Taylor; Catherine McClinton; Theodore Pincus; NN NN

doi:http://dx.doi.org/10.1136/ard.2006.069252

QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.

Tuulikki Sokka, Hannu Kautiainen, Sergio Toloza, Heidi Mäkinen, Suzan M M Verstappen, Merete Lund Hetland, Antonio Naranjo, Eva Baecklund, Gertraud Herborn, Rolf Rau, Massimiliano Cazzato, Laure Gossec, Vlado Skakic, Feride Gogus, Stanislaw Sierakowski, Barry Bresnihan, Peter Taylor, Catherine McClinton, Theodore Pincus, NN NN

Department of Clinical Medicine

179 Citations (Scopus)

Abstract

OBJECTIVE: To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment-related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 (disease activity score on 28-joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. RESULTS: Between January 2005 and October 2006, the QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female, >90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries (p<0.001). Among 42 sites with >50 patients included, low disease activity of DAS28 50% of patients had high disease activity of DAS28 >5.1. CONCLUSIONS: This international multicentre cross-sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005-6 including countries that are infrequently involved in clinical research projects.

Original language	English
Journal	Annals of the Rheumatic Diseases
Volume	66
Issue number	11
Pages (from-to)	1491-6
Number of pages	5
ISSN	0003-4967
DOIs	https://doi.org/10.1136/ard.2006.069252
Publication status	Published - 2007

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Sokka, T., Kautiainen, H., Toloza, S., Mäkinen, H., Verstappen, S. M. M., Hetland, M. L., Naranjo, A., Baecklund, E., Herborn, G., Rau, R., Cazzato, M., Gossec, L., Skakic, V., Gogus, F., Sierakowski, S., Bresnihan, B., Taylor, P., McClinton, C., Pincus, T., & NN, NN. (2007). QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. Annals of the Rheumatic Diseases, 66(11), 1491-6. https://doi.org/10.1136/ard.2006.069252

Sokka, T, Kautiainen, H, Toloza, S, Mäkinen, H, Verstappen, SMM, Hetland, ML, Naranjo, A, Baecklund, E, Herborn, G, Rau, R, Cazzato, M, Gossec, L, Skakic, V, Gogus, F, Sierakowski, S, Bresnihan, B, Taylor, P, McClinton, C, Pincus, T & NN, NN 2007, 'QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.', Annals of the Rheumatic Diseases, vol. 66, no. 11, pp. 1491-6. https://doi.org/10.1136/ard.2006.069252

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title = "QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.",

abstract = "OBJECTIVE: To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment-related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 (disease activity score on 28-joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. RESULTS: Between January 2005 and October 2006, the QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female, >90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries (p<0.001). Among 42 sites with >50 patients included, low disease activity of DAS28 50% of patients had high disease activity of DAS28 >5.1. CONCLUSIONS: This international multicentre cross-sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005-6 including countries that are infrequently involved in clinical research projects.",

author = "Tuulikki Sokka and Hannu Kautiainen and Sergio Toloza and Heidi M{\"a}kinen and Verstappen, {Suzan M M} and Hetland, {Merete Lund} and Antonio Naranjo and Eva Baecklund and Gertraud Herborn and Rolf Rau and Massimiliano Cazzato and Laure Gossec and Vlado Skakic and Feride Gogus and Stanislaw Sierakowski and Barry Bresnihan and Peter Taylor and Catherine McClinton and Theodore Pincus and NN NN",

year = "2007",

doi = "http://dx.doi.org/10.1136/ard.2006.069252",

language = "English",

volume = "66",

pages = "1491--6",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

publisher = "B M J Group",

number = "11",

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TY - JOUR

T1 - QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.

AU - Sokka, Tuulikki

AU - Kautiainen, Hannu

AU - Toloza, Sergio

AU - Mäkinen, Heidi

AU - Verstappen, Suzan M M

AU - Hetland, Merete Lund

AU - Naranjo, Antonio

AU - Baecklund, Eva

AU - Herborn, Gertraud

AU - Rau, Rolf

AU - Cazzato, Massimiliano

AU - Gossec, Laure

AU - Skakic, Vlado

AU - Gogus, Feride

AU - Sierakowski, Stanislaw

AU - Bresnihan, Barry

AU - Taylor, Peter

AU - McClinton, Catherine

AU - Pincus, Theodore

AU - NN, NN

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment-related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 (disease activity score on 28-joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. RESULTS: Between January 2005 and October 2006, the QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female, >90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries (p<0.001). Among 42 sites with >50 patients included, low disease activity of DAS28 50% of patients had high disease activity of DAS28 >5.1. CONCLUSIONS: This international multicentre cross-sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005-6 including countries that are infrequently involved in clinical research projects.

AB - OBJECTIVE: To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment-related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 (disease activity score on 28-joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. RESULTS: Between January 2005 and October 2006, the QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female, >90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries (p<0.001). Among 42 sites with >50 patients included, low disease activity of DAS28 50% of patients had high disease activity of DAS28 >5.1. CONCLUSIONS: This international multicentre cross-sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005-6 including countries that are infrequently involved in clinical research projects.

U2 - http://dx.doi.org/10.1136/ard.2006.069252

DO - http://dx.doi.org/10.1136/ard.2006.069252

M3 - Journal article

SN - 0003-4967

VL - 66

SP - 1491

EP - 1496

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 11

ER -

QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.

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