Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity

TY - JOUR

T1 - Quantitative assessment of eosinophiluria in Schistosoma haematobium infections

T2 - a new marker of infection and bladder morbidity

AU - Reimert, C M

AU - Mshinda, H M

AU - Hatz, C F

AU - Kombe, Y

AU - Nkulila, T

AU - Poulsen, Lars K.

AU - Christensen, N O

AU - Vennervald, B J

PY - 2000/1

Y1 - 2000/1

N2 - Eosinophiluria, as quantified by measuring eosinophil cationic protein (ECP) in urinary extracts, microhematuria, egg excretion, and ultrasound-detectable bladder pathology were recorded in Schistosoma haematobium-infected Tanzanian school children at a baseline survey and during an 18-month post-treatment follow-up study. Significant correlations were seen between urinary ECP levels, intensity of infection, and bladder pathology. Treatment resulted in a marked reduction in prevalence and intensity of infection, in a delayed and less marked reduction in ECP levels, and in a resolution of pathology. The overall diagnostic efficiency of the ECP test (cut-off value for the ECP > or =5 ng/ml) in relation to infection was comparable with that of egg count and microhematuria, but with a better sensitivity than a single egg count. In relation to bladder pathology, the diagnostic performance of the ECP test (cut-off value for the ECP > or =25 ng/ml) exceeded that of a single egg count. In addition, the ECP was better in discriminating between different grades of bladder pathology. The present study points to the ECP as a useful marker of both S. haematobium infection and of associated bladder morbidity reflecting the inflammatory status of the bladder wall.

AB - Eosinophiluria, as quantified by measuring eosinophil cationic protein (ECP) in urinary extracts, microhematuria, egg excretion, and ultrasound-detectable bladder pathology were recorded in Schistosoma haematobium-infected Tanzanian school children at a baseline survey and during an 18-month post-treatment follow-up study. Significant correlations were seen between urinary ECP levels, intensity of infection, and bladder pathology. Treatment resulted in a marked reduction in prevalence and intensity of infection, in a delayed and less marked reduction in ECP levels, and in a resolution of pathology. The overall diagnostic efficiency of the ECP test (cut-off value for the ECP > or =5 ng/ml) in relation to infection was comparable with that of egg count and microhematuria, but with a better sensitivity than a single egg count. In relation to bladder pathology, the diagnostic performance of the ECP test (cut-off value for the ECP > or =25 ng/ml) exceeded that of a single egg count. In addition, the ECP was better in discriminating between different grades of bladder pathology. The present study points to the ECP as a useful marker of both S. haematobium infection and of associated bladder morbidity reflecting the inflammatory status of the bladder wall.

KW - Adolescent

KW - Animals

KW - Anthelmintics

KW - Blood Proteins

KW - Child

KW - Cohort Studies

KW - Enzyme-Linked Immunosorbent Assay

KW - Eosinophil Granule Proteins

KW - Eosinophils

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Inflammation Mediators

KW - Male

KW - Morbidity

KW - Parasite Egg Count

KW - Praziquantel

KW - Predictive Value of Tests

KW - Ribonucleases

KW - Schistosoma haematobium

KW - Schistosomiasis haematobia

KW - Statistics, Nonparametric

KW - Tanzania

KW - Urinary Bladder

KW - Urinary Bladder Diseases

KW - Urine

M3 - Journal article

C2 - 10761720

SN - 0002-9637

VL - 62

SP - 19

EP - 28

JO - Journal. National Malaria Society

JF - Journal. National Malaria Society

IS - 1

ER -