Quantification of Lung Metastases from In Vivo Mouse Models

TY - CHAP

T1 - Quantification of Lung Metastases from In Vivo Mouse Models

AU - Chang, Joan

AU - Erler, Janine T

PY - 2016

Y1 - 2016

N2 - Cancer research has made significant progress in terms of understanding and targeting primary tumors; however, the challenge remains for the successful treatment of metastatic cancers. This highlights the importance to use in vivo models to study the metastatic process, as well as for preclinical testing of compounds that could inhibit metastasis. As a result, proper quantification of metastases from in vivo models is of the utmost significance. Here, we provide a detailed protocol for collecting and handling lung tissues from mice, and guidance for subsequent analysis of metastases, as well as interpretation of data.

AB - Cancer research has made significant progress in terms of understanding and targeting primary tumors; however, the challenge remains for the successful treatment of metastatic cancers. This highlights the importance to use in vivo models to study the metastatic process, as well as for preclinical testing of compounds that could inhibit metastasis. As a result, proper quantification of metastases from in vivo models is of the utmost significance. Here, we provide a detailed protocol for collecting and handling lung tissues from mice, and guidance for subsequent analysis of metastases, as well as interpretation of data.

KW - Journal Article

U2 - 10.1007/978-3-319-26666-4_14

DO - 10.1007/978-3-319-26666-4_14

M3 - Book chapter

C2 - 27325271

SN - 978-3-319-26664-0

VL - 899

T3 - Advances in Experimental Medicine and Biology

SP - 245

EP - 251

BT - Advances in Experimental Medicine and Biology

A2 - Koumenis, Constantinos

A2 - Coussens, Lisa M.

A2 - Giaccia, Amato

A2 - Hammond, Ester

PB - Springer

ER -