Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

Casper P Hagen; Kaspar Sørensen; Lise Aksglaede; Annette Mouritsen; Mikkel G Mieritz; Jeanette Tinggaard; Christine Wohlfahrt-Veje; Jørgen Holm Petersen; Katharina M. Main; Ewa Rajpert-De Meyts; Kristian Almstrup; Anders Juul

Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

Casper P Hagen, Kaspar Sørensen, Lise Aksglaede, Annette Mouritsen, Mikkel G Mieritz, Jeanette Tinggaard, Christine Wohlfahrt-Veje, Jørgen Holm Petersen, Katharina M. Main, Ewa Rajpert-De Meyts, Kristian Almstrup, Anders Juul

Section of Biostatistics

26 Citations (Scopus)

Abstract

Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

Original language	Danish
Article number	6412
Journal	Scientific Reports
Volume	4
Pages (from-to)	1-6
Number of pages	6
ISSN	2045-2322
Publication status	Published - Sept 2014

Cite this

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title = "Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action",

abstract = "Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.",

author = "Hagen, {Casper P} and Kaspar S{\o}rensen and Lise Aksglaede and Annette Mouritsen and Mieritz, {Mikkel G} and Jeanette Tinggaard and Christine Wohlfahrt-Veje and Petersen, {J{\o}rgen Holm} and Main, {Katharina M.} and {Rajpert-De Meyts}, Ewa and Kristian Almstrup and Anders Juul",

year = "2014",

month = sep,

language = "Dansk",

volume = "4",

pages = "1--6",

journal = "Scientific Reports",

issn = "2045-2322",

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TY - JOUR

T1 - Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

AU - Hagen, Casper P

AU - Sørensen, Kaspar

AU - Aksglaede, Lise

AU - Mouritsen, Annette

AU - Mieritz, Mikkel G

AU - Tinggaard, Jeanette

AU - Wohlfahrt-Veje, Christine

AU - Petersen, Jørgen Holm

AU - Main, Katharina M.

AU - Rajpert-De Meyts, Ewa

AU - Almstrup, Kristian

AU - Juul, Anders

PY - 2014/9

Y1 - 2014/9

N2 - Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

AB - Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5-12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.

M3 - Tidsskriftartikel

SN - 2045-2322

VL - 4

SP - 1

EP - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 6412

ER -