Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth.

TY - JOUR

T1 - Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth.

AU - Høiby, N

AU - Krogh Johansen, H

AU - Moser, C

AU - Song, Z

AU - Ciofu, O

AU - Kharazmi, A

N1 - Keywords: Animals; Anti-Bacterial Agents; Biofilms; Chronic Disease; Cystic Fibrosis; Drug Resistance, Microbial; Endopeptidases; Humans; Inflammation; Lung; Neutrophils; Pseudomonas Infections; Pseudomonas aeruginosa

PY - 2001

Y1 - 2001

N2 - The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.

AB - The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.

M3 - Journal article

C2 - 11226851

SN - 1286-4579

VL - 3

SP - 23

EP - 35

JO - Microbes and Infection

JF - Microbes and Infection

IS - 1

ER -