Proteoglycans in health and disease: the multiple roles of syndecan shedding

TY - JOUR

T1 - Proteoglycans in health and disease: the multiple roles of syndecan shedding

AU - Manon-Jensen, Tina

AU - Itoh, Yoshifumi

AU - Couchman, John R

N1 - © 2010 The Authors Journal compilation © 2010 FEBS.

PY - 2010/10

Y1 - 2010/10

N2 - Proteolytic processes in the extracellular matrix are a major influence on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface proteoglycans are important mediators of cell spreading on extracellular matrix and respond to growth factors and other biologically active polypeptides. The ectodomain of each syndecan is constitutively shed from many cultured cells, but is accelerated in response to wound healing and diverse pathophysiological events. Ectodomain shedding is an important regulatory mechanism, because it rapidly changes surface receptor dynamics and generates soluble ectodomains that can function as paracrine or autocrine effectors, or competitive inhibitors. It is known that the family of syndecans can be shed by a variety of matrix proteinase, including many metzincins. Shedding is particularly active in proliferating and invasive cells, such as cancer cells, where cell-surface components are continually released. Here, recent research into the shedding of syndecans and its physiological relevance are assessed.

AB - Proteolytic processes in the extracellular matrix are a major influence on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface proteoglycans are important mediators of cell spreading on extracellular matrix and respond to growth factors and other biologically active polypeptides. The ectodomain of each syndecan is constitutively shed from many cultured cells, but is accelerated in response to wound healing and diverse pathophysiological events. Ectodomain shedding is an important regulatory mechanism, because it rapidly changes surface receptor dynamics and generates soluble ectodomains that can function as paracrine or autocrine effectors, or competitive inhibitors. It is known that the family of syndecans can be shed by a variety of matrix proteinase, including many metzincins. Shedding is particularly active in proliferating and invasive cells, such as cancer cells, where cell-surface components are continually released. Here, recent research into the shedding of syndecans and its physiological relevance are assessed.

U2 - 10.1111/j.1742-4658.2010.07798.x

DO - 10.1111/j.1742-4658.2010.07798.x

M3 - Journal article

C2 - 20840585

SN - 1742-464X

VL - 277

SP - 3876

EP - 3889

JO - FEBS Journal

JF - FEBS Journal

IS - 19

ER -