Abstract
This chapter discusses recent advances and the main advantages of block copolymers for functional membrane protein reconstitution in biomimetic polymeric membranes. A rational approach to the reconstitution of membrane proteins in a functional form can be addressed by a more holistic view by using other kind of nonbiological amphiphilic molecules. An interesting possibility could be the use of self-assembled proteins in a lipid-free membrane mimicking the capside of some viruses. The membrane proteins that have been more actively used in combination with block copolymer membranes are gramicidin A and other small peptides, aquaporins, OpmF, bacteriorhodopsin, and the more complex ATP synthase.
| Original language | English |
|---|---|
| Title of host publication | Proteins in Solution and at Interface : Methods and Applications in Biotechnology and Materials Science |
| Editors | J.M. Ruso, A. Piñeiro |
| Number of pages | 8 |
| Place of Publication | Hoboken, NJ, USA. |
| Publisher | Wiley |
| Publication date | 5 Mar 2013 |
| Pages | 283-290 |
| Chapter | 13 |
| ISBN (Print) | 9780470952511 |
| DOIs | |
| Publication status | Published - 5 Mar 2013 |
Keywords
- Biomimetic polymeric membranes
- Block copolymer membranes
- Lipid membranes
- Peptides
- Proteins