Protein annotation in the era of personal genomics

Thomas Blicher; Ramneek Gupta; Agata Wesolowska; Lars Juhl Jensen; Søren Brunak

doi:10.1016/j.sbi.2010.03.008

Protein annotation in the era of personal genomics

Thomas Blicher, Ramneek Gupta, Agata Wesolowska, Lars Juhl Jensen, Søren Brunak

Abstract

Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.

Original language	English
Journal	Current Opinion in Structural Biology
Volume	20
Issue number	3
Pages (from-to)	335-41
Number of pages	7
ISSN	0959-440X
DOIs	https://doi.org/10.1016/j.sbi.2010.03.008
Publication status	Published - 1 Jun 2010

Keywords

Amino Acid Motifs
Amino Acid Sequence
Animals
Genome, Human
Genomics
Humans
Molecular Sequence Data
Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.sbi.2010.03.008

Cite this

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title = "Protein annotation in the era of personal genomics",

abstract = "Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.",

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AU - Gupta, Ramneek

AU - Wesolowska, Agata

AU - Jensen, Lars Juhl

AU - Brunak, Søren

PY - 2010/6/1

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AB - Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.

KW - Amino Acid Motifs

KW - Amino Acid Sequence

KW - Animals

KW - Genome, Human

KW - Genomics

KW - Humans

KW - Molecular Sequence Data

KW - Proteins

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DO - 10.1016/j.sbi.2010.03.008

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SP - 335

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JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

IS - 3

ER -

Protein annotation in the era of personal genomics

Abstract

Keywords

UN SDGs

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