Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms

Zhijun Song; Lotte Borgwardt; Niels Høiby; Hong Wu; Torben Sandberg Sørensen; Arne Borgwardt

doi:10.4081/or.2013.e14

Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms

Zhijun Song, Lotte Borgwardt, Niels Høiby, Hong Wu, Torben Sandberg Sørensen, Arne Borgwardt

Abstract

Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore, important to understand the comprehensive interaction between the microbiological situation and the host immune responses that lead to prosthesis infections. Evidence indicates that prosthesis infections are actually biofilm-correlated infections that are highly resistant to antibiotic treatment and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future treatment options of prosthesis-related infections are discussed.

Original language	English
Journal	Orthopedic Reviews
Volume	5
Issue number	2
Pages (from-to)	65-71
Number of pages	7
ISSN	2035-8237
DOIs	https://doi.org/10.4081/or.2013.e14
Publication status	Published - 7 Jun 2013

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title = "Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms",

abstract = "Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore, important to understand the comprehensive interaction between the microbiological situation and the host immune responses that lead to prosthesis infections. Evidence indicates that prosthesis infections are actually biofilm-correlated infections that are highly resistant to antibiotic treatment and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future treatment options of prosthesis-related infections are discussed.",

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T1 - Prosthesis infections after orthopedic joint replacement

T2 - the possible role of bacterial biofilms

AU - Song, Zhijun

AU - Borgwardt, Lotte

AU - Høiby, Niels

AU - Wu, Hong

AU - Sørensen, Torben Sandberg

AU - Borgwardt, Arne

PY - 2013/6/7

Y1 - 2013/6/7

N2 - Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore, important to understand the comprehensive interaction between the microbiological situation and the host immune responses that lead to prosthesis infections. Evidence indicates that prosthesis infections are actually biofilm-correlated infections that are highly resistant to antibiotic treatment and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future treatment options of prosthesis-related infections are discussed.

AB - Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore, important to understand the comprehensive interaction between the microbiological situation and the host immune responses that lead to prosthesis infections. Evidence indicates that prosthesis infections are actually biofilm-correlated infections that are highly resistant to antibiotic treatment and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future treatment options of prosthesis-related infections are discussed.

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DO - 10.4081/or.2013.e14

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JO - Orthopedic Reviews

JF - Orthopedic Reviews

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Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms

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