Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids

Sanela Smajilovic; Petrine Wellendorph; Hans Bräuner-Osborne

doi:10.2174/13816128113199990576

Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids

Sanela Smajilovic, Petrine Wellendorph, Hans Bräuner-Osborne

6 Citations (Scopus)

Abstract

A number of nutrient sensing seven trans-membrane (7TM) receptors have been identified and characterized over the past few years. While the sensing mechanisms to carbohydrates and free fatty acids are well understood, the molecular basis of amino acid sensing has recently come to the limelight. The present review describes the current status of promiscuous L-α-amino acid sensors, the calcium sensing receptor (CaSR), the GPRC6A receptor, the T1R1/T1R3 receptor and also their molecular pharmacology, expression pattern and physiological significance.

Original language	English
Journal	Current Pharmaceutical Design
Volume	20
Pages (from-to)	2693-702
Number of pages	10
DOIs	https://doi.org/10.2174/13816128113199990576
Publication status	Published - 2014

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abstract = "A number of nutrient sensing seven trans-membrane (7TM) receptors have been identified and characterized over the past few years. While the sensing mechanisms to carbohydrates and free fatty acids are well understood, the molecular basis of amino acid sensing has recently come to the limelight. The present review describes the current status of promiscuous L-α-amino acid sensors, the calcium sensing receptor (CaSR), the GPRC6A receptor, the T1R1/T1R3 receptor and also their molecular pharmacology, expression pattern and physiological significance.",

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AU - Smajilovic, Sanela

AU - Wellendorph, Petrine

AU - Bräuner-Osborne, Hans

PY - 2014

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N2 - A number of nutrient sensing seven trans-membrane (7TM) receptors have been identified and characterized over the past few years. While the sensing mechanisms to carbohydrates and free fatty acids are well understood, the molecular basis of amino acid sensing has recently come to the limelight. The present review describes the current status of promiscuous L-α-amino acid sensors, the calcium sensing receptor (CaSR), the GPRC6A receptor, the T1R1/T1R3 receptor and also their molecular pharmacology, expression pattern and physiological significance.

AB - A number of nutrient sensing seven trans-membrane (7TM) receptors have been identified and characterized over the past few years. While the sensing mechanisms to carbohydrates and free fatty acids are well understood, the molecular basis of amino acid sensing has recently come to the limelight. The present review describes the current status of promiscuous L-α-amino acid sensors, the calcium sensing receptor (CaSR), the GPRC6A receptor, the T1R1/T1R3 receptor and also their molecular pharmacology, expression pattern and physiological significance.

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DO - 10.2174/13816128113199990576

M3 - Journal article

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VL - 20

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EP - 2702

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

ER -

Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids

Abstract

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