Prolonged activated prothromboplastin time and breed specific variation in haemostatic analytes in healthy adult Bernese Mountain dogs

Lise Nielsen; Bo Wiinberg; Mads Kjelgaard-Hansen; Asger Lundorff Jensen; Annemarie Thuri Kristensen

doi:10.1016/j.tvjl.2010.09.016

Prolonged activated prothromboplastin time and breed specific variation in haemostatic analytes in healthy adult Bernese Mountain dogs

Lise Nielsen, Bo Wiinberg, Mads Kjelgaard-Hansen, Asger Lundorff Jensen, Annemarie Thuri Kristensen

11 Citations (Scopus)

Abstract

Coagulation tests are often performed in dogs suspected of haemostatic dysfunction and are interpreted according to validated laboratory reference intervals (RIs). Breed specific RIs for haematological and biochemical analytes have previously been identified in Bernese Mountain dogs, but it remains to be determined if breed specific RIs are necessary for haemostasis tests. Activated prothromboplastin time (aPTT), prothrombin time (PT), selected coagulation factors, D-dimers, fibrinogen, von Willebrand factor and thromboelastography (TEG) were analyzed in healthy Bernese Mountain dogs using the CLSI model.

Three analytes (aPTT, TEG [MA] and TEG [G]) were different according to the CLSI model. For aPTT the new RI was markedly different (0-100 s). Whereas the new intervals for TEG (MA) and TEG (G) may be due to breed related biological variation, the cause of the prolonged RI for aPTT is at present uncertain.

Original language	English
Journal	Veterinary Journal
Volume	190
Issue number	1
Pages (from-to)	150-153
Number of pages	4
ISSN	1090-0233
DOIs	https://doi.org/10.1016/j.tvjl.2010.09.016
Publication status	Published - Oct 2011

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title = "Prolonged activated prothromboplastin time and breed specific variation in haemostatic analytes in healthy adult Bernese Mountain dogs",

abstract = "Coagulation tests are often performed in dogs suspected of haemostatic dysfunction and are interpreted according to validated laboratory reference intervals (RIs). Breed specific RIs for haematological and biochemical analytes have previously been identified in Bernese Mountain dogs, but it remains to be determined if breed specific RIs are necessary for haemostasis tests. Activated prothromboplastin time (aPTT), prothrombin time (PT), selected coagulation factors, D-dimers, fibrinogen, von Willebrand factor and thromboelastography (TEG) were analyzed in healthy Bernese Mountain dogs using the CLSI model.Three analytes (aPTT, TEG [MA] and TEG [G]) were different according to the CLSI model. For aPTT the new RI was markedly different (0-100 s). Whereas the new intervals for TEG (MA) and TEG (G) may be due to breed related biological variation, the cause of the prolonged RI for aPTT is at present uncertain.",

author = "Lise Nielsen and Bo Wiinberg and Mads Kjelgaard-Hansen and Jensen, {Asger Lundorff} and Kristensen, {Annemarie Thuri}",

year = "2011",

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doi = "10.1016/j.tvjl.2010.09.016",

language = "English",

volume = "190",

pages = "150--153",

journal = "Veterinary Journal",

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T1 - Prolonged activated prothromboplastin time and breed specific variation in haemostatic analytes in healthy adult Bernese Mountain dogs

AU - Nielsen, Lise

AU - Wiinberg, Bo

AU - Kjelgaard-Hansen, Mads

AU - Jensen, Asger Lundorff

AU - Kristensen, Annemarie Thuri

PY - 2011/10

Y1 - 2011/10

N2 - Coagulation tests are often performed in dogs suspected of haemostatic dysfunction and are interpreted according to validated laboratory reference intervals (RIs). Breed specific RIs for haematological and biochemical analytes have previously been identified in Bernese Mountain dogs, but it remains to be determined if breed specific RIs are necessary for haemostasis tests. Activated prothromboplastin time (aPTT), prothrombin time (PT), selected coagulation factors, D-dimers, fibrinogen, von Willebrand factor and thromboelastography (TEG) were analyzed in healthy Bernese Mountain dogs using the CLSI model.Three analytes (aPTT, TEG [MA] and TEG [G]) were different according to the CLSI model. For aPTT the new RI was markedly different (0-100 s). Whereas the new intervals for TEG (MA) and TEG (G) may be due to breed related biological variation, the cause of the prolonged RI for aPTT is at present uncertain.

AB - Coagulation tests are often performed in dogs suspected of haemostatic dysfunction and are interpreted according to validated laboratory reference intervals (RIs). Breed specific RIs for haematological and biochemical analytes have previously been identified in Bernese Mountain dogs, but it remains to be determined if breed specific RIs are necessary for haemostasis tests. Activated prothromboplastin time (aPTT), prothrombin time (PT), selected coagulation factors, D-dimers, fibrinogen, von Willebrand factor and thromboelastography (TEG) were analyzed in healthy Bernese Mountain dogs using the CLSI model.Three analytes (aPTT, TEG [MA] and TEG [G]) were different according to the CLSI model. For aPTT the new RI was markedly different (0-100 s). Whereas the new intervals for TEG (MA) and TEG (G) may be due to breed related biological variation, the cause of the prolonged RI for aPTT is at present uncertain.

U2 - 10.1016/j.tvjl.2010.09.016

DO - 10.1016/j.tvjl.2010.09.016

M3 - Journal article

C2 - 21035361

SN - 1090-0233

VL - 190

SP - 150

EP - 153

JO - Veterinary Journal

JF - Veterinary Journal

IS - 1

ER -

Prolonged activated prothromboplastin time and breed specific variation in haemostatic analytes in healthy adult Bernese Mountain dogs

Abstract

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