Prognostic value of periodic electroencephalographic discharges for neurological patients with profound disturbances of consciousness

TY - JOUR

T1 - Prognostic value of periodic electroencephalographic discharges for neurological patients with profound disturbances of consciousness

AU - Pedersen, Gyrithe L

AU - Rasmussen, Stine

AU - Gyllenborg, Jesper

AU - Benedek, Krisztina

AU - Lauritzen, Martin

PY - 2013/1

Y1 - 2013/1

N2 - Objective: To examine if periodic EEG discharges (PDs) predict poor outcome and development of epilepsy in patients with acute brain illnesses irrespective of underlying cerebral pathology. Methods: In case-control study we retrospectively analyzed outcome of 102 patients with PDs and 102 age-, gender- and etiology matched controls without PDs. Results: Of cases, 46.1% had lateralized PDs (LPDs), 3.9% bilateral PDs (BIPDs), 15.7% generalized PDs (GPDs) and 34.3% had combinations thereof. Etiology: Stroke was most common cause of LPDs (53%), cardiac arrest of GPDs (10.5%), previous stroke, CNS infection, anoxia and metabolic encephalopathy all caused 1 case of BIPDs. Outcome: Mortality rate and acquired disability was significantly higher in patients with PDs than in controls, odds ratio (OR) 2.5, 95% CI 1.43-4.40 (p= 0.001). Patients with PDs without superimposed EEG activity had worse outcome than patients with superimposed EEG activity. Tardive epilepsy: Patients with LPDs associated with fast superimposed EEG activity (LPDs-plus) had higher risk for tardive epilepsy than patients with LPDs alone (p= 0.034). Conclusion: PDs predicted poor functional outcome and patients with LPDs-plus had higher risk for later development of epilepsy. Significance: Detailed evaluation of PDs provided valuable prognostic information in neurological patients with disturbed consciousness.

AB - Objective: To examine if periodic EEG discharges (PDs) predict poor outcome and development of epilepsy in patients with acute brain illnesses irrespective of underlying cerebral pathology. Methods: In case-control study we retrospectively analyzed outcome of 102 patients with PDs and 102 age-, gender- and etiology matched controls without PDs. Results: Of cases, 46.1% had lateralized PDs (LPDs), 3.9% bilateral PDs (BIPDs), 15.7% generalized PDs (GPDs) and 34.3% had combinations thereof. Etiology: Stroke was most common cause of LPDs (53%), cardiac arrest of GPDs (10.5%), previous stroke, CNS infection, anoxia and metabolic encephalopathy all caused 1 case of BIPDs. Outcome: Mortality rate and acquired disability was significantly higher in patients with PDs than in controls, odds ratio (OR) 2.5, 95% CI 1.43-4.40 (p= 0.001). Patients with PDs without superimposed EEG activity had worse outcome than patients with superimposed EEG activity. Tardive epilepsy: Patients with LPDs associated with fast superimposed EEG activity (LPDs-plus) had higher risk for tardive epilepsy than patients with LPDs alone (p= 0.034). Conclusion: PDs predicted poor functional outcome and patients with LPDs-plus had higher risk for later development of epilepsy. Significance: Detailed evaluation of PDs provided valuable prognostic information in neurological patients with disturbed consciousness.

U2 - 10.1016/j.clinph.2012.06.010

DO - 10.1016/j.clinph.2012.06.010

M3 - Journal article

C2 - 22809812

SN - 1388-2457

VL - 124

SP - 44

EP - 51

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 1

ER -