Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations

Hong-Qi Fan; Yan Li; Lutgarde Thijs; Tine W Hansen; José Boggia; Masahiro Kikuya; Kristina Björklund-Bodegård; Tom Richart; Takayoshi Ohkubo; Jørgen Jeppesen; Christian Torp-Pedersen; Eamon Dolan; Tatiana Kuznetsova; Katarzyna Stolarz-Skrzypek; Valérie Tikhonoff; Sofia Malyutina; Edoardo Casiglia; Yuri Nikitin; Lars Solskov Lind; Edgardo Sandoya; Kalina Kawecka-Jaszcz; Yutaka Imai; Hans Ibsen; Eoin O'Brien; Jiguang Wang; Jan A Staessen; International Database on Ambulatory Blood Pressure In Relation to Cardiovascular Outcomes Investigators; Yan Li

doi:10.1097/hjh.0b013e32833b49fe

Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations

Hong-Qi Fan, Yan Li, Lutgarde Thijs, Tine W Hansen, José Boggia, Masahiro Kikuya, Kristina Björklund-Bodegård, Tom Richart, Takayoshi Ohkubo, Jørgen Jeppesen, Christian Torp-Pedersen, Eamon Dolan, Tatiana Kuznetsova, Katarzyna Stolarz-Skrzypek, Valérie Tikhonoff, Sofia Malyutina, Edoardo Casiglia, Yuri Nikitin, Lars Solskov Lind, Edgardo SandoyaKalina Kawecka-Jaszcz, Yutaka Imai, Hans Ibsen, Eoin O'Brien, Jiguang Wang, Jan A Staessen, International Database on Ambulatory Blood Pressure In Relation to Cardiovascular Outcomes Investigators, Yan Li

243 Citations (Scopus)

Abstract

Background: We and other investigators previously reported that isolated nocturnal hypertension on ambulatory measurement (INH) clustered with cardiovascular risk factors and was associated with intermediate target organ damage. We investigated whether INH might also predict hard cardiovascular endpoints. Methods and results: We monitored blood pressure (BP) throughout the day and followed health outcomes in 8711 individuals randomly recruited from 10 populations (mean age 54.8 years, 47.0% women). Of these, 577 untreated individuals had INH (daytime BP <135/85 mmHg and night-time BP ≥120/70 mmHg) and 994 untreated individuals had isolated daytime hypertension on ambulatory measurement (IDH; daytime BP ≥135/85 mmHg and night-time BP <120/70 mmHg). During follow-up (median 10.7 years), 1284 deaths (501 cardiovascular) occurred and 1109 participants experienced a fatal or nonfatal cardiovascular event. In multivariable-adjusted analyses, compared with normotension (n = 3837), INH was associated with a higher risk of total mortality (hazard ratio 1.29, P = 0.045) and all cardiovascular events (hazard ratio 1.38, P = 0.037). IDH was associated with increases in all cardiovascular events (hazard ratio 1.46, P = 0.0019) and cardiac endpoints (hazard ratio 1.53, P = 0.0061). Of 577 patients with INH, 457 were normotensive (<140/90 mmHg) on office BP measurement. Hazard ratios associated with INH with additional adjustment for office BP were 1.31 (P = 0.039) and 1.38 (P = 0.044) for total mortality and all cardiovascular events, respectively. After exclusion of patients with office hypertension, these hazard ratios were 1.17 (P = 0.31) and 1.48 (P = 0.034). Conclusion: INH predicts cardiovascular outcome in patients who are normotensive on office or on ambulatory daytime BP measurement.

Original language	English
Journal	Journal of Hypertension
Volume	28
Issue number	10
Pages (from-to)	2036-45
Number of pages	10
ISSN	0263-6352
DOIs	https://doi.org/10.1097/hjh.0b013e32833b49fe
Publication status	Published - 1 Oct 2010

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10.1097/hjh.0b013e32833b49fe

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Fan, H-Q., Li, Y., Thijs, L., Hansen, T. W., Boggia, J., Kikuya, M., Björklund-Bodegård, K., Richart, T., Ohkubo, T., Jeppesen, J., Torp-Pedersen, C., Dolan, E., Kuznetsova, T., Stolarz-Skrzypek, K., Tikhonoff, V., Malyutina, S., Casiglia, E., Nikitin, Y., Lind, L. S., ... Li, Y. (2010). Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations. Journal of Hypertension, 28(10), 2036-45. https://doi.org/10.1097/hjh.0b013e32833b49fe

Fan, H-Q, Li, Y, Thijs, L, Hansen, TW, Boggia, J, Kikuya, M, Björklund-Bodegård, K, Richart, T, Ohkubo, T, Jeppesen, J, Torp-Pedersen, C, Dolan, E, Kuznetsova, T, Stolarz-Skrzypek, K, Tikhonoff, V, Malyutina, S, Casiglia, E, Nikitin, Y, Lind, LS, Sandoya, E, Kawecka-Jaszcz, K, Imai, Y, Ibsen, H, O'Brien, E, Wang, J, Staessen, JA, International Database on Ambulatory Blood Pressure In Relation to Cardiovascular Outcomes Investigators & Li, Y 2010, 'Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations', Journal of Hypertension, vol. 28, no. 10, pp. 2036-45. https://doi.org/10.1097/hjh.0b013e32833b49fe

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title = "Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations",

abstract = "Background: We and other investigators previously reported that isolated nocturnal hypertension on ambulatory measurement (INH) clustered with cardiovascular risk factors and was associated with intermediate target organ damage. We investigated whether INH might also predict hard cardiovascular endpoints. Methods and results: We monitored blood pressure (BP) throughout the day and followed health outcomes in 8711 individuals randomly recruited from 10 populations (mean age 54.8 years, 47.0% women). Of these, 577 untreated individuals had INH (daytime BP <135/85 mmHg and night-time BP ≥120/70 mmHg) and 994 untreated individuals had isolated daytime hypertension on ambulatory measurement (IDH; daytime BP ≥135/85 mmHg and night-time BP <120/70 mmHg). During follow-up (median 10.7 years), 1284 deaths (501 cardiovascular) occurred and 1109 participants experienced a fatal or nonfatal cardiovascular event. In multivariable-adjusted analyses, compared with normotension (n = 3837), INH was associated with a higher risk of total mortality (hazard ratio 1.29, P = 0.045) and all cardiovascular events (hazard ratio 1.38, P = 0.037). IDH was associated with increases in all cardiovascular events (hazard ratio 1.46, P = 0.0019) and cardiac endpoints (hazard ratio 1.53, P = 0.0061). Of 577 patients with INH, 457 were normotensive (<140/90 mmHg) on office BP measurement. Hazard ratios associated with INH with additional adjustment for office BP were 1.31 (P = 0.039) and 1.38 (P = 0.044) for total mortality and all cardiovascular events, respectively. After exclusion of patients with office hypertension, these hazard ratios were 1.17 (P = 0.31) and 1.48 (P = 0.034). Conclusion: INH predicts cardiovascular outcome in patients who are normotensive on office or on ambulatory daytime BP measurement.",

author = "Hong-Qi Fan and Yan Li and Lutgarde Thijs and Hansen, {Tine W} and Jos{\'e} Boggia and Masahiro Kikuya and Kristina Bj{\"o}rklund-Bodeg{\aa}rd and Tom Richart and Takayoshi Ohkubo and J{\o}rgen Jeppesen and Christian Torp-Pedersen and Eamon Dolan and Tatiana Kuznetsova and Katarzyna Stolarz-Skrzypek and Val{\'e}rie Tikhonoff and Sofia Malyutina and Edoardo Casiglia and Yuri Nikitin and Lind, {Lars Solskov} and Edgardo Sandoya and Kalina Kawecka-Jaszcz and Yutaka Imai and Hans Ibsen and Eoin O'Brien and Jiguang Wang and Staessen, {Jan A} and Torp-Pedersen, {Christian Tobias} and Yan Li",

year = "2010",

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doi = "10.1097/hjh.0b013e32833b49fe",

language = "English",

volume = "28",

pages = "2036--45",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Lippincott Williams & Wilkins, Ltd.",

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TY - JOUR

T1 - Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations

AU - Fan, Hong-Qi

AU - Li, Yan

AU - Thijs, Lutgarde

AU - Hansen, Tine W

AU - Boggia, José

AU - Kikuya, Masahiro

AU - Björklund-Bodegård, Kristina

AU - Richart, Tom

AU - Ohkubo, Takayoshi

AU - Jeppesen, Jørgen

AU - Torp-Pedersen, Christian

AU - Dolan, Eamon

AU - Kuznetsova, Tatiana

AU - Stolarz-Skrzypek, Katarzyna

AU - Tikhonoff, Valérie

AU - Malyutina, Sofia

AU - Casiglia, Edoardo

AU - Nikitin, Yuri

AU - Lind, Lars Solskov

AU - Sandoya, Edgardo

AU - Kawecka-Jaszcz, Kalina

AU - Imai, Yutaka

AU - Ibsen, Hans

AU - O'Brien, Eoin

AU - Wang, Jiguang

AU - Staessen, Jan A

AU - International Database on Ambulatory Blood Pressure In Relation to Cardiovascular Outcomes Investigators

AU - Li, Yan

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Background: We and other investigators previously reported that isolated nocturnal hypertension on ambulatory measurement (INH) clustered with cardiovascular risk factors and was associated with intermediate target organ damage. We investigated whether INH might also predict hard cardiovascular endpoints. Methods and results: We monitored blood pressure (BP) throughout the day and followed health outcomes in 8711 individuals randomly recruited from 10 populations (mean age 54.8 years, 47.0% women). Of these, 577 untreated individuals had INH (daytime BP <135/85 mmHg and night-time BP ≥120/70 mmHg) and 994 untreated individuals had isolated daytime hypertension on ambulatory measurement (IDH; daytime BP ≥135/85 mmHg and night-time BP <120/70 mmHg). During follow-up (median 10.7 years), 1284 deaths (501 cardiovascular) occurred and 1109 participants experienced a fatal or nonfatal cardiovascular event. In multivariable-adjusted analyses, compared with normotension (n = 3837), INH was associated with a higher risk of total mortality (hazard ratio 1.29, P = 0.045) and all cardiovascular events (hazard ratio 1.38, P = 0.037). IDH was associated with increases in all cardiovascular events (hazard ratio 1.46, P = 0.0019) and cardiac endpoints (hazard ratio 1.53, P = 0.0061). Of 577 patients with INH, 457 were normotensive (<140/90 mmHg) on office BP measurement. Hazard ratios associated with INH with additional adjustment for office BP were 1.31 (P = 0.039) and 1.38 (P = 0.044) for total mortality and all cardiovascular events, respectively. After exclusion of patients with office hypertension, these hazard ratios were 1.17 (P = 0.31) and 1.48 (P = 0.034). Conclusion: INH predicts cardiovascular outcome in patients who are normotensive on office or on ambulatory daytime BP measurement.

AB - Background: We and other investigators previously reported that isolated nocturnal hypertension on ambulatory measurement (INH) clustered with cardiovascular risk factors and was associated with intermediate target organ damage. We investigated whether INH might also predict hard cardiovascular endpoints. Methods and results: We monitored blood pressure (BP) throughout the day and followed health outcomes in 8711 individuals randomly recruited from 10 populations (mean age 54.8 years, 47.0% women). Of these, 577 untreated individuals had INH (daytime BP <135/85 mmHg and night-time BP ≥120/70 mmHg) and 994 untreated individuals had isolated daytime hypertension on ambulatory measurement (IDH; daytime BP ≥135/85 mmHg and night-time BP <120/70 mmHg). During follow-up (median 10.7 years), 1284 deaths (501 cardiovascular) occurred and 1109 participants experienced a fatal or nonfatal cardiovascular event. In multivariable-adjusted analyses, compared with normotension (n = 3837), INH was associated with a higher risk of total mortality (hazard ratio 1.29, P = 0.045) and all cardiovascular events (hazard ratio 1.38, P = 0.037). IDH was associated with increases in all cardiovascular events (hazard ratio 1.46, P = 0.0019) and cardiac endpoints (hazard ratio 1.53, P = 0.0061). Of 577 patients with INH, 457 were normotensive (<140/90 mmHg) on office BP measurement. Hazard ratios associated with INH with additional adjustment for office BP were 1.31 (P = 0.039) and 1.38 (P = 0.044) for total mortality and all cardiovascular events, respectively. After exclusion of patients with office hypertension, these hazard ratios were 1.17 (P = 0.31) and 1.48 (P = 0.034). Conclusion: INH predicts cardiovascular outcome in patients who are normotensive on office or on ambulatory daytime BP measurement.

U2 - 10.1097/hjh.0b013e32833b49fe

DO - 10.1097/hjh.0b013e32833b49fe

M3 - Journal article

SN - 0263-6352

VL - 28

SP - 2036

EP - 2045

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 10

ER -

Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations

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