Prognostic impact of hs-CRP and IL-6 in patients undergoing radiofrequency catheter ablation for atrial fibrillation

Kristoffer Mads Aaris Henningsen; Brian Nilsson; Helle Bruunsgaard; Xu Chen; Bente Klarlund Pedersen; Jesper Hastrup Svendsen

doi:10.1080/14017430802653676

Prognostic impact of hs-CRP and IL-6 in patients undergoing radiofrequency catheter ablation for atrial fibrillation

Kristoffer Mads Aaris Henningsen, Brian Nilsson, Helle Bruunsgaard, Xu Chen, Bente Klarlund Pedersen, Jesper Hastrup Svendsen

Department of Clinical Medicine

38 Citations (Scopus)

Abstract

Aim. The aim of this study was to assess the predictive value of inflammatory markers in patients with paroxysmal/ persistent atrial fibrillation (AF) treated with radiofrequency (RF) catheter ablation. Methods. Forty-six consecutive patients, mean age 55 years (range 31 - 81 yrs), with paroxysmal or persistent AF were treated with either segmental or circumferential pulmonary vein isolation ablation technique. All patients presented with sinus rhythm on inclusion. Holter monitoring lasting at least 14 days was performed before ablation and after 3 months. Recurrent symptomatic AF or atrial tachycardia >10 minutes was considered failure and patients were offered a second ablation session. Interleukin-6 and high-sensitivity C-reactive protein were measured prior to ablation and at follow-up visits. Results. After a maximum of two ablations, 19 patients (41%) had SR without recurrence of AF after 12 months. Patients in SR had significantly lower left atrium diameter (p=0.007) and lower values of both IL-6 (p=0.007) and hs-CRP (p=0.018) at baseline before ablation. IL-6 concentration prior to ablation was an independent predictor of recurrent AF (p=0.027). Conclusion. In patients with a history of paroxysmal or persistent AF treated with RF catheter ablation, elevated levels of IL-6 and hs-CRP before ablation are independent predictors of recurrence of AF
Udgivelsesdato: 2008/12/31

Original language	English
Journal	Scandinavian Cardiovascular Journal
Volume	43
Issue number	5
Pages (from-to)	285-91
Number of pages	6
ISSN	1401-7431
DOIs	https://doi.org/10.1080/14017430802653676
Publication status	Published - 2008

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10.1080/14017430802653676

Cite this

@article{543bf550072a11de8478000ea68e967b,

title = "Prognostic impact of hs-CRP and IL-6 in patients undergoing radiofrequency catheter ablation for atrial fibrillation",

abstract = "Aim. The aim of this study was to assess the predictive value of inflammatory markers in patients with paroxysmal/ persistent atrial fibrillation (AF) treated with radiofrequency (RF) catheter ablation. Methods. Forty-six consecutive patients, mean age 55 years (range 31 - 81 yrs), with paroxysmal or persistent AF were treated with either segmental or circumferential pulmonary vein isolation ablation technique. All patients presented with sinus rhythm on inclusion. Holter monitoring lasting at least 14 days was performed before ablation and after 3 months. Recurrent symptomatic AF or atrial tachycardia >10 minutes was considered failure and patients were offered a second ablation session. Interleukin-6 and high-sensitivity C-reactive protein were measured prior to ablation and at follow-up visits. Results. After a maximum of two ablations, 19 patients (41%) had SR without recurrence of AF after 12 months. Patients in SR had significantly lower left atrium diameter (p=0.007) and lower values of both IL-6 (p=0.007) and hs-CRP (p=0.018) at baseline before ablation. IL-6 concentration prior to ablation was an independent predictor of recurrent AF (p=0.027). Conclusion. In patients with a history of paroxysmal or persistent AF treated with RF catheter ablation, elevated levels of IL-6 and hs-CRP before ablation are independent predictors of recurrence of AF Udgivelsesdato: 2008/12/31",

author = "Henningsen, {Kristoffer Mads Aaris} and Brian Nilsson and Helle Bruunsgaard and Xu Chen and Pedersen, {Bente Klarlund} and Svendsen, {Jesper Hastrup}",

year = "2008",

doi = "10.1080/14017430802653676",

language = "English",

volume = "43",

pages = "285--91",

journal = "Scandinavian Cardiovascular Journal, Supplement",

issn = "1401-7458",

publisher = "Taylor & Francis",

number = "5",

}

TY - JOUR

T1 - Prognostic impact of hs-CRP and IL-6 in patients undergoing radiofrequency catheter ablation for atrial fibrillation

AU - Henningsen, Kristoffer Mads Aaris

AU - Nilsson, Brian

AU - Bruunsgaard, Helle

AU - Chen, Xu

AU - Pedersen, Bente Klarlund

AU - Svendsen, Jesper Hastrup

PY - 2008

Y1 - 2008

N2 - Aim. The aim of this study was to assess the predictive value of inflammatory markers in patients with paroxysmal/ persistent atrial fibrillation (AF) treated with radiofrequency (RF) catheter ablation. Methods. Forty-six consecutive patients, mean age 55 years (range 31 - 81 yrs), with paroxysmal or persistent AF were treated with either segmental or circumferential pulmonary vein isolation ablation technique. All patients presented with sinus rhythm on inclusion. Holter monitoring lasting at least 14 days was performed before ablation and after 3 months. Recurrent symptomatic AF or atrial tachycardia >10 minutes was considered failure and patients were offered a second ablation session. Interleukin-6 and high-sensitivity C-reactive protein were measured prior to ablation and at follow-up visits. Results. After a maximum of two ablations, 19 patients (41%) had SR without recurrence of AF after 12 months. Patients in SR had significantly lower left atrium diameter (p=0.007) and lower values of both IL-6 (p=0.007) and hs-CRP (p=0.018) at baseline before ablation. IL-6 concentration prior to ablation was an independent predictor of recurrent AF (p=0.027). Conclusion. In patients with a history of paroxysmal or persistent AF treated with RF catheter ablation, elevated levels of IL-6 and hs-CRP before ablation are independent predictors of recurrence of AF Udgivelsesdato: 2008/12/31

AB - Aim. The aim of this study was to assess the predictive value of inflammatory markers in patients with paroxysmal/ persistent atrial fibrillation (AF) treated with radiofrequency (RF) catheter ablation. Methods. Forty-six consecutive patients, mean age 55 years (range 31 - 81 yrs), with paroxysmal or persistent AF were treated with either segmental or circumferential pulmonary vein isolation ablation technique. All patients presented with sinus rhythm on inclusion. Holter monitoring lasting at least 14 days was performed before ablation and after 3 months. Recurrent symptomatic AF or atrial tachycardia >10 minutes was considered failure and patients were offered a second ablation session. Interleukin-6 and high-sensitivity C-reactive protein were measured prior to ablation and at follow-up visits. Results. After a maximum of two ablations, 19 patients (41%) had SR without recurrence of AF after 12 months. Patients in SR had significantly lower left atrium diameter (p=0.007) and lower values of both IL-6 (p=0.007) and hs-CRP (p=0.018) at baseline before ablation. IL-6 concentration prior to ablation was an independent predictor of recurrent AF (p=0.027). Conclusion. In patients with a history of paroxysmal or persistent AF treated with RF catheter ablation, elevated levels of IL-6 and hs-CRP before ablation are independent predictors of recurrence of AF Udgivelsesdato: 2008/12/31

U2 - 10.1080/14017430802653676

DO - 10.1080/14017430802653676

M3 - Journal article

C2 - 19117239

SN - 1401-7458

VL - 43

SP - 285

EP - 291

JO - Scandinavian Cardiovascular Journal, Supplement

JF - Scandinavian Cardiovascular Journal, Supplement

IS - 5

ER -