Abstract
Background: Allogeneic haematopoietic stem cell transplantation (HSCT) is a procedure with inherent complications and intensive care may be necessary. We evaluated the short- and long-term outcomes of the HSCT recipients requiring admission to the intensive care unit (ICU). Methods: We retrospectively examined the outcome of 54 adult haematological HSCT recipients admitted to the ICU at the University Hospital Rigshospitalet between January 2007 and March 2012. Results: The overall in-ICU, in-hospital, 6-month and 1-year mortality rates were 46.3, 75.9, 79.6 and 86.5%, respectively. Mechanical ventilation had a statistically significant effect on in-ICU (p = 0.02), 6-month (p = 0.049) and 1-year (p = 0.014) mortality. Renal replacement therapy also had a statistically significant effect on in-hospital (p = 0.038) and 6-month (p = 0.026) mortality. Short ICU admissions, i.e. <10 days, had a statistically significant positive effect on in-hospital, 6-month and 1-year mortality (all p < 0.001). The SAPS II, APACHE II and SOFA scoring systems grossly underestimated the actual in-hospital mortality observed for these patients. Conclusion: The poor prognosis of critically ill HSCT recipients admitted to the ICU was confirmed in our study. Mechanical ventilation, renal replacement therapy and an ICU admission of ≥10 days were each risk factors for mortality in the first year after ICU admission.
| Original language | English |
|---|---|
| Journal | Acta Haematologica |
| Volume | 135 |
| Issue number | 2 |
| Pages (from-to) | 72-78 |
| Number of pages | 7 |
| ISSN | 0001-5792 |
| DOIs | |
| Publication status | Published - 1 Feb 2016 |
Keywords
- Adolescent
- Adult
- Aged
- Critical Illness
- Female
- Graft vs Host Disease
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
- Hospital Mortality
- Hospitals, University
- Humans
- Intensive Care Units
- Lymphoma
- Male
- Middle Aged
- Prognosis
- Renal Replacement Therapy
- Retrospective Studies
- Transplantation, Homologous
- Young Adult