Production of polyhydroxybutyrate in wood-ljungdahl microorganisms

TY - PAT

T1 - Production of polyhydroxybutyrate in wood-ljungdahl microorganisms

AU - Tappel, Ryan

AU - Behrendorff, James Bruce Yarnton H

AU - Koepke, Michael

AU - Marcellin, Esteban

AU - Lemgruber, Renato de S. P.

AU - Valgepea, Kaspar

AU - Nielsen, Lars Keld

PY - 2019/4/25

Y1 - 2019/4/25

N2 - The invention provides microorganisms and methods for the production of polyhydroxybutyrate (PHB) from gaseous substrates. In particular, the invention provides a non-naturally occurring Wood-Ljungdahl microorganism comprising (a) an enzyme that converts acetyl-CoA to acetoacetyl-CoA,(b) an enzyme that converts acetoacetyl-CoA to 3-hydroxybutyryl-CoA, and (c) an enzyme that converts 3-hydroxybutyryl-CoA to polyhydroxybutyrate, and methods related thereto.

AB - The invention provides microorganisms and methods for the production of polyhydroxybutyrate (PHB) from gaseous substrates. In particular, the invention provides a non-naturally occurring Wood-Ljungdahl microorganism comprising (a) an enzyme that converts acetyl-CoA to acetoacetyl-CoA,(b) an enzyme that converts acetoacetyl-CoA to 3-hydroxybutyryl-CoA, and (c) an enzyme that converts 3-hydroxybutyryl-CoA to polyhydroxybutyrate, and methods related thereto.

M3 - Patent

M1 - US20190119706A1

PB - Lanzatech, Inc.

ER -