Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

Morten Bækgaard Thomsen; Avram Oros; Marieke Schoenmakers; Jurren M van Opstal; Joep N Maas; Jet D M Beekman; Marc A Vos

doi:10.1016/j.cardiores.2006.11.025

Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

Morten Bækgaard Thomsen, Avram Oros, Marieke Schoenmakers, Jurren M van Opstal, Joep N Maas, Jet D M Beekman, Marc A Vos

Physiology of circulation, kidney and lung

70 Citations (Scopus)

Abstract

Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.

Original language	English
Journal	Cardiovascular Research
Volume	73
Issue number	3
Pages (from-to)	521-30
Number of pages	10
ISSN	0008-6363
DOIs	https://doi.org/10.1016/j.cardiores.2006.11.025
Publication status	Published - 1 Feb 2007

Keywords

Action Potentials
Acute Disease
Animals
Arrhythmias, Cardiac
Death, Sudden, Cardiac
Dogs
Electrocardiography
Female
Heart Block
Heart Conduction System
Heart Rate
Male
Phenethylamines
Potassium Channel Blockers
Sulfonamides
Torsades de Pointes
Ventricular Remodeling

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10.1016/j.cardiores.2006.11.025

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Thomsen, M. B., Oros, A., Schoenmakers, M., van Opstal, J. M., Maas, J. N., Beekman, J. D. M., & Vos, M. A. (2007). Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. Cardiovascular Research, 73(3), 521-30. https://doi.org/10.1016/j.cardiores.2006.11.025

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title = "Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation",

abstract = "Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.",

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AU - Thomsen, Morten Bækgaard

AU - Oros, Avram

AU - Schoenmakers, Marieke

AU - van Opstal, Jurren M

AU - Maas, Joep N

AU - Beekman, Jet D M

AU - Vos, Marc A

PY - 2007/2/1

Y1 - 2007/2/1

N2 - Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.

AB - Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.

KW - Action Potentials

KW - Acute Disease

KW - Animals

KW - Arrhythmias, Cardiac

KW - Death, Sudden, Cardiac

KW - Dogs

KW - Electrocardiography

KW - Female

KW - Heart Block

KW - Heart Conduction System

KW - Heart Rate

KW - Male

KW - Phenethylamines

KW - Potassium Channel Blockers

KW - Sulfonamides

KW - Torsades de Pointes

KW - Ventricular Remodeling

U2 - 10.1016/j.cardiores.2006.11.025

DO - 10.1016/j.cardiores.2006.11.025

M3 - Journal article

C2 - 17196569

SN - 0008-6363

VL - 73

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EP - 530

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -

Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

Abstract

Keywords

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