Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

TY - JOUR

T1 - Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

AU - Thomsen, Morten Bækgaard

AU - Oros, Avram

AU - Schoenmakers, Marieke

AU - van Opstal, Jurren M

AU - Maas, Joep N

AU - Beekman, Jet D M

AU - Vos, Marc A

PY - 2007/2/1

Y1 - 2007/2/1

N2 - Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.

AB - Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.

KW - Action Potentials

KW - Acute Disease

KW - Animals

KW - Arrhythmias, Cardiac

KW - Death, Sudden, Cardiac

KW - Dogs

KW - Electrocardiography

KW - Female

KW - Heart Block

KW - Heart Conduction System

KW - Heart Rate

KW - Male

KW - Phenethylamines

KW - Potassium Channel Blockers

KW - Sulfonamides

KW - Torsades de Pointes

KW - Ventricular Remodeling

U2 - 10.1016/j.cardiores.2006.11.025

DO - 10.1016/j.cardiores.2006.11.025

M3 - Journal article

C2 - 17196569

SN - 0008-6363

VL - 73

SP - 521

EP - 530

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -