Priming With intermittent theta burst transcranial magnetic stimulation promotes spinal plasticity induced by peripheral patterned electrical stimulation

TY - JOUR

T1 - Priming With intermittent theta burst transcranial magnetic stimulation promotes spinal plasticity induced by peripheral patterned electrical stimulation

AU - Yamaguchi, Tomofumi

AU - Fujiwara, Toshiyuki

AU - Lin, Su Chuan

AU - Takahashi, Yoko

AU - Hatori, Kozo

AU - Liu, Meigen

AU - Huang, Ying Zu

PY - 2018

Y1 - 2018

N2 - This study explored the effect of corticospinal activity on spinal plasticity by examining the interactions between intermittent theta burst transcranial magnetic stimulation (iTBS) of the motor cortex and peripheral patterned electrical stimulation (PES) of the common peroneal nerve (CPN). Healthy volunteers (n = 10) received iTBS to the tibialis anterior (TA) muscle zone of the motor cortex and PES of the CPN in three separate sessions: (1) iTBS-before-PES, (2) iTBS-after-PES, and (3) sham iTBS-before-PES. The PES protocol used 10 100-Hz pulses every 2 s for 20 min. Reciprocal inhibition (RI) from the TA to soleus muscle and motor cortical excitability of the TA and soleus muscles were assessed at baseline, before PES, and 0, 15, 30, and 45 min after PES. When compared to the other protocols, iTBS-before-PES significantly increased changes in disynaptic RI for 15 min and altered long-loop presynaptic inhibition immediately after PES. Moreover, the iTBS-induced cortical excitability changes in the TA before PES were correlated with the enhancement of disynaptic RI immediately after PES. These results demonstrate that spinal plasticity can be modified by altering cortical excitability. This study provides insight into the interactions between modulation of corticospinal excitability and spinal RI, which may help in developing new rehabilitation strategies.

AB - This study explored the effect of corticospinal activity on spinal plasticity by examining the interactions between intermittent theta burst transcranial magnetic stimulation (iTBS) of the motor cortex and peripheral patterned electrical stimulation (PES) of the common peroneal nerve (CPN). Healthy volunteers (n = 10) received iTBS to the tibialis anterior (TA) muscle zone of the motor cortex and PES of the CPN in three separate sessions: (1) iTBS-before-PES, (2) iTBS-after-PES, and (3) sham iTBS-before-PES. The PES protocol used 10 100-Hz pulses every 2 s for 20 min. Reciprocal inhibition (RI) from the TA to soleus muscle and motor cortical excitability of the TA and soleus muscles were assessed at baseline, before PES, and 0, 15, 30, and 45 min after PES. When compared to the other protocols, iTBS-before-PES significantly increased changes in disynaptic RI for 15 min and altered long-loop presynaptic inhibition immediately after PES. Moreover, the iTBS-induced cortical excitability changes in the TA before PES were correlated with the enhancement of disynaptic RI immediately after PES. These results demonstrate that spinal plasticity can be modified by altering cortical excitability. This study provides insight into the interactions between modulation of corticospinal excitability and spinal RI, which may help in developing new rehabilitation strategies.

KW - Disynaptic reciprocal inhibition

KW - H-reflex

KW - Non-invasive brain stimulation

KW - Presynaptic inhibition

KW - Spinal plasticity

U2 - 10.3389/fnins.2018.00508

DO - 10.3389/fnins.2018.00508

M3 - Journal article

C2 - 30087593

AN - SCOPUS:85050351069

SN - 1662-4548

VL - 12

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

IS - JUL

M1 - 508

ER -