TY - JOUR
T1 - Primary mucosal melanoma of the head and neck in Denmark, 1982-2012
T2 - Demographic and clinical aspects. A retrospective DAHANCA study
AU - Lawaetz, Mads
AU - Birch-Johansen, Fatima
AU - Friis, Søren
AU - Eriksen, Jesper G
AU - Kiss, Katalin
AU - Gade, Søren
AU - Møller-Madsen, Maria
AU - Pourbordbari, Negar
AU - von Buchwald, Christian
PY - 2016/8/2
Y1 - 2016/8/2
N2 - Abstract: Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national retrospective multicenter study of patients diagnosed with MMHN between 1982 and 2012 in Denmark. Data were retrieved from national databases and patient records. Incidence trends were examined for the entire period. We prepared survival curves and performed univariate and multivariate analysis for the period 1992–2012 to identify possible prognostic factors. Results No significant trends in incidence were found in the study period. The three-year overall and disease-free survival rates for MMHN were 46.5% and 35.5%, respectively. Negative margins was an independent predictor of disease-free survival, and age below 65, absence of distant metastases, and low overall TNM stage were predictors of overall survival. Radiotherapy did not improve survival significantly. Recurrence rates were high, even for patients with negative margins. Conclusions MMHN remains a rare disease with a poor prognosis, particularly for patients aged over 65, those with distant metastasis, and those with advanced TNM stage. Importantly, the rate of recurrence is lowest in patients with negative margins.
AB - Abstract: Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national retrospective multicenter study of patients diagnosed with MMHN between 1982 and 2012 in Denmark. Data were retrieved from national databases and patient records. Incidence trends were examined for the entire period. We prepared survival curves and performed univariate and multivariate analysis for the period 1992–2012 to identify possible prognostic factors. Results No significant trends in incidence were found in the study period. The three-year overall and disease-free survival rates for MMHN were 46.5% and 35.5%, respectively. Negative margins was an independent predictor of disease-free survival, and age below 65, absence of distant metastases, and low overall TNM stage were predictors of overall survival. Radiotherapy did not improve survival significantly. Recurrence rates were high, even for patients with negative margins. Conclusions MMHN remains a rare disease with a poor prognosis, particularly for patients aged over 65, those with distant metastasis, and those with advanced TNM stage. Importantly, the rate of recurrence is lowest in patients with negative margins.
KW - Aged
KW - Denmark
KW - Disease-Free Survival
KW - Female
KW - Head and Neck Neoplasms
KW - Humans
KW - Male
KW - Melanoma
KW - Middle Aged
KW - Mucous Membrane
KW - Neoplasm Recurrence, Local
KW - Retrospective Studies
KW - Journal Article
KW - Multicenter Study
U2 - 10.3109/0284186x.2016.1143117
DO - 10.3109/0284186x.2016.1143117
M3 - Journal article
C2 - 27031263
SN - 0284-186X
VL - 55
SP - 1001
EP - 1008
JO - Acta Oncologica
JF - Acta Oncologica
IS - 8
ER -