Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort

Anne Gedebjerg; Thomas Peter Almdal; Klara Berencsi; Jørgen Rungby; Jens Steen Nielsen; Daniel R. Witte; Søren Friborg; Ivan Brandslund; Allan Vaag; Henning Beck-Nielsen; Henrik Toft Sørensen; Reimar Wernich Thomsen

doi:10.1016/j.jdiacomp.2017.09.010

Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort

Anne Gedebjerg, Thomas Peter Almdal, Klara Berencsi, Jørgen Rungby, Jens Steen Nielsen, Daniel R. Witte, Søren Friborg, Ivan Brandslund, Allan Vaag, Henning Beck-Nielsen, Henrik Toft Sørensen, Reimar Wernich Thomsen

Department of Clinical Medicine

36 Citations (Scopus)

Abstract

AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.

METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.

RESULTS: In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.

CONCLUSIONS: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications.

Original language	English
Journal	Journal of Diabetes and its Complications
Volume	32
Issue number	1
Pages (from-to)	34-40
Number of pages	7
ISSN	1056-8727
DOIs	https://doi.org/10.1016/j.jdiacomp.2017.09.010
Publication status	Published - Jan 2018

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Gedebjerg, A., Almdal, T. P., Berencsi, K., Rungby, J., Nielsen, J. S., Witte, D. R., Friborg, S., Brandslund, I., Vaag, A., Beck-Nielsen, H., Sørensen, H. T., & Thomsen, R. W. (2018). Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort. Journal of Diabetes and its Complications, 32(1), 34-40. https://doi.org/10.1016/j.jdiacomp.2017.09.010

Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort. / Gedebjerg, Anne; Almdal, Thomas Peter; Berencsi, Klara et al.
In: Journal of Diabetes and its Complications, Vol. 32, No. 1, 01.2018, p. 34-40.

Research output: Contribution to journal › Journal article › Research › peer-review

Gedebjerg, A, Almdal, TP, Berencsi, K, Rungby, J, Nielsen, JS, Witte, DR, Friborg, S, Brandslund, I, Vaag, A, Beck-Nielsen, H, Sørensen, HT & Thomsen, RW 2018, 'Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort', Journal of Diabetes and its Complications, vol. 32, no. 1, pp. 34-40. https://doi.org/10.1016/j.jdiacomp.2017.09.010

Gedebjerg A, Almdal TP, Berencsi K, Rungby J, Nielsen JS, Witte DR et al. Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort. Journal of Diabetes and its Complications. 2018 Jan;32(1):34-40. doi: 10.1016/j.jdiacomp.2017.09.010

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title = "Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort",

abstract = "AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.RESULTS: In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.CONCLUSIONS: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications.",

author = "Anne Gedebjerg and Almdal, {Thomas Peter} and Klara Berencsi and J{\o}rgen Rungby and Nielsen, {Jens Steen} and Witte, {Daniel R.} and S{\o}ren Friborg and Ivan Brandslund and Allan Vaag and Henning Beck-Nielsen and S{\o}rensen, {Henrik Toft} and Thomsen, {Reimar Wernich}",

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doi = "10.1016/j.jdiacomp.2017.09.010",

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T1 - Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics

T2 - A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort

AU - Gedebjerg, Anne

AU - Almdal, Thomas Peter

AU - Berencsi, Klara

AU - Rungby, Jørgen

AU - Nielsen, Jens Steen

AU - Witte, Daniel R.

AU - Friborg, Søren

AU - Brandslund, Ivan

AU - Vaag, Allan

AU - Beck-Nielsen, Henning

AU - Sørensen, Henrik Toft

AU - Thomsen, Reimar Wernich

PY - 2018/1

Y1 - 2018/1

N2 - AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.RESULTS: In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.CONCLUSIONS: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications.

AB - AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.RESULTS: In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.CONCLUSIONS: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications.

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DO - 10.1016/j.jdiacomp.2017.09.010

M3 - Journal article

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SN - 1056-8727

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JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

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