Prevalence of anti-hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades

Lene Holm Harritshøj; Ditte Marie Kirkegaard-Klitbo; Niels Mejer; Inge Panum; Sofie Elisabeth Midgley; Henrik Ullum; Thomas Benfield

doi:10.1016/j.ijid.2019.04.029

Prevalence of anti-hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades

Lene Holm Harritshøj^*, Ditte Marie Kirkegaard-Klitbo, Niels Mejer, Inge Panum, Sofie Elisabeth Midgley, Henrik Ullum, Thomas Benfield

^*Corresponding author for this work

Department of Clinical Medicine

4 Citations (Scopus)

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Abstract

Background: Hepatitis E virus (HEV)genotype 3 is endemic in Europe, and the infection is mostly subclinical or acute and self-limiting. However, persistent infection is described among HIV-infected individuals. The prevalence of antibodies against HEV (anti-HEV)among HIV-infected persons varies geographically and is unknown in Denmark. Rates of co-infection with HEV among HIV-infected individuals in Denmark over three decades, from the early 1980s to 2013, were investigated. Methods: A total of 2506 HIV-infected persons were investigated from two cohorts followed at Hvidovre Hospital, Denmark. Blood samples were tested retrospectively for anti-HEV, including samples from 2216 persons who were enrolled in a prospective clinical cohort and followed between 1995 and 2013, as well as samples from 290 persons from a historical cohort followed between 1980 and 1994. For anti-HEV seroconverting individuals, serial samples were tested for HEV RNA. Factors associated with anti-HEV status were explored using multivariable logistic regression analysis. Results: The overall HEV seroprevalence rates were stable during the 1980s, 1990s, and 2000–2013 (23.1%, 22.9%, and 23.7%, respectively). In all decades, rates of anti-HEV increased with older age, and anti-HEV seropositivity was associated with older generations, HIV risk group, and geographic origin. Persistent HEV infection was not detected in any of 57 individuals with anti-HEV seroconversion. Conclusions: HEV seroprevalence rates were stable in HIV-infected individuals from the early 1980s to 2013. Rates increased with age. No evidence of persistent HEV infection was detected. Infection with HEV is frequent, but persistent HEV infection is rare among HIV-infected individuals.

Original language	English
Journal	International Journal of Infectious Diseases
Volume	84
Pages (from-to)	67-72
Number of pages	6
ISSN	1201-9712
DOIs	https://doi.org/10.1016/j.ijid.2019.04.029
Publication status	Published - 2019

Keywords

Hepatitis E virus
HEV
HIV
Persistent HEV RNA
Prevalence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Prevalence of anti-hepatitis E virus immunoglobulin G in HIV-infected individuals over three decadesFinal published version, 662 KBLicence: CC BY-NC-ND

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@article{f60da3632d3441e6bea0e6bd94b891ad,

title = "Prevalence of anti-hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades",

abstract = "Background: Hepatitis E virus (HEV)genotype 3 is endemic in Europe, and the infection is mostly subclinical or acute and self-limiting. However, persistent infection is described among HIV-infected individuals. The prevalence of antibodies against HEV (anti-HEV)among HIV-infected persons varies geographically and is unknown in Denmark. Rates of co-infection with HEV among HIV-infected individuals in Denmark over three decades, from the early 1980s to 2013, were investigated. Methods: A total of 2506 HIV-infected persons were investigated from two cohorts followed at Hvidovre Hospital, Denmark. Blood samples were tested retrospectively for anti-HEV, including samples from 2216 persons who were enrolled in a prospective clinical cohort and followed between 1995 and 2013, as well as samples from 290 persons from a historical cohort followed between 1980 and 1994. For anti-HEV seroconverting individuals, serial samples were tested for HEV RNA. Factors associated with anti-HEV status were explored using multivariable logistic regression analysis. Results: The overall HEV seroprevalence rates were stable during the 1980s, 1990s, and 2000–2013 (23.1%, 22.9%, and 23.7%, respectively). In all decades, rates of anti-HEV increased with older age, and anti-HEV seropositivity was associated with older generations, HIV risk group, and geographic origin. Persistent HEV infection was not detected in any of 57 individuals with anti-HEV seroconversion. Conclusions: HEV seroprevalence rates were stable in HIV-infected individuals from the early 1980s to 2013. Rates increased with age. No evidence of persistent HEV infection was detected. Infection with HEV is frequent, but persistent HEV infection is rare among HIV-infected individuals.",

keywords = "Hepatitis E virus, HEV, HIV, Persistent HEV RNA, Prevalence",

author = "Harritsh{\o}j, {Lene Holm} and Kirkegaard-Klitbo, {Ditte Marie} and Niels Mejer and Inge Panum and Midgley, {Sofie Elisabeth} and Henrik Ullum and Thomas Benfield",

year = "2019",

doi = "10.1016/j.ijid.2019.04.029",

language = "English",

volume = "84",

pages = "67--72",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier",

}

TY - JOUR

T1 - Prevalence of anti-hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades

AU - Harritshøj, Lene Holm

AU - Kirkegaard-Klitbo, Ditte Marie

AU - Mejer, Niels

AU - Panum, Inge

AU - Midgley, Sofie Elisabeth

AU - Ullum, Henrik

AU - Benfield, Thomas

PY - 2019

Y1 - 2019

N2 - Background: Hepatitis E virus (HEV)genotype 3 is endemic in Europe, and the infection is mostly subclinical or acute and self-limiting. However, persistent infection is described among HIV-infected individuals. The prevalence of antibodies against HEV (anti-HEV)among HIV-infected persons varies geographically and is unknown in Denmark. Rates of co-infection with HEV among HIV-infected individuals in Denmark over three decades, from the early 1980s to 2013, were investigated. Methods: A total of 2506 HIV-infected persons were investigated from two cohorts followed at Hvidovre Hospital, Denmark. Blood samples were tested retrospectively for anti-HEV, including samples from 2216 persons who were enrolled in a prospective clinical cohort and followed between 1995 and 2013, as well as samples from 290 persons from a historical cohort followed between 1980 and 1994. For anti-HEV seroconverting individuals, serial samples were tested for HEV RNA. Factors associated with anti-HEV status were explored using multivariable logistic regression analysis. Results: The overall HEV seroprevalence rates were stable during the 1980s, 1990s, and 2000–2013 (23.1%, 22.9%, and 23.7%, respectively). In all decades, rates of anti-HEV increased with older age, and anti-HEV seropositivity was associated with older generations, HIV risk group, and geographic origin. Persistent HEV infection was not detected in any of 57 individuals with anti-HEV seroconversion. Conclusions: HEV seroprevalence rates were stable in HIV-infected individuals from the early 1980s to 2013. Rates increased with age. No evidence of persistent HEV infection was detected. Infection with HEV is frequent, but persistent HEV infection is rare among HIV-infected individuals.

AB - Background: Hepatitis E virus (HEV)genotype 3 is endemic in Europe, and the infection is mostly subclinical or acute and self-limiting. However, persistent infection is described among HIV-infected individuals. The prevalence of antibodies against HEV (anti-HEV)among HIV-infected persons varies geographically and is unknown in Denmark. Rates of co-infection with HEV among HIV-infected individuals in Denmark over three decades, from the early 1980s to 2013, were investigated. Methods: A total of 2506 HIV-infected persons were investigated from two cohorts followed at Hvidovre Hospital, Denmark. Blood samples were tested retrospectively for anti-HEV, including samples from 2216 persons who were enrolled in a prospective clinical cohort and followed between 1995 and 2013, as well as samples from 290 persons from a historical cohort followed between 1980 and 1994. For anti-HEV seroconverting individuals, serial samples were tested for HEV RNA. Factors associated with anti-HEV status were explored using multivariable logistic regression analysis. Results: The overall HEV seroprevalence rates were stable during the 1980s, 1990s, and 2000–2013 (23.1%, 22.9%, and 23.7%, respectively). In all decades, rates of anti-HEV increased with older age, and anti-HEV seropositivity was associated with older generations, HIV risk group, and geographic origin. Persistent HEV infection was not detected in any of 57 individuals with anti-HEV seroconversion. Conclusions: HEV seroprevalence rates were stable in HIV-infected individuals from the early 1980s to 2013. Rates increased with age. No evidence of persistent HEV infection was detected. Infection with HEV is frequent, but persistent HEV infection is rare among HIV-infected individuals.

KW - Hepatitis E virus

KW - HEV

KW - HIV

KW - Persistent HEV RNA

KW - Prevalence

U2 - 10.1016/j.ijid.2019.04.029

DO - 10.1016/j.ijid.2019.04.029

M3 - Journal article

C2 - 31063824

AN - SCOPUS:85065973839

SN - 1201-9712

VL - 84

SP - 67

EP - 72

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Prevalence of anti-hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades

Abstract

Keywords

UN SDGs

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